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1. |
Prospective Controlled Study of Androgen Effects on Red Cell Oxygen Transport and Work Capacity in Chronic Hemodialysis Patients |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 1-8
Ernesto D. Hendler,
Lawrence R. Solomon,
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摘要:
Effects of androgens on red blood cell (RBC) oxygen transport, RBC metabolism and work capacity in chronic hemodialysis patients were evaluated in a prospective controlled study. Compared to control subjects, patients given nandrolone decanoate had a sustained fall in RBC ATP and a transient rise in RBC DPG but P50 values were unchanged. Despite increases in RBC mass of 16–44% on androgen therapy, excercise on the treadmill improved in only 1 patient and actually declined in 3 others. Thus, these preliminary observations suggest that androgens may not improve hemoglobin-oxygen transport and that androgen-induced increases in red cell mass may only balance increased tissue oxygen requirements produced by these anabolic hormone
ISSN:0001-5792
DOI:10.1159/000205154
出版商:S. Karger AG
年代:1990
数据来源: Karger
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2. |
Splenic Foam Cells: A Clinico-Pathologic Analysis of 92 Splenectomized Patients |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 9-15
Mohamed B. Satti,
Abdulla Abu Melha,
Mohamed O. Al-Sohaibani,
Saleh Al-Sowayan,
Abdulaziz Al-Quorain,
Ezzeldin M. Ibrahim,
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摘要:
Spleens from 92 patients who underwent splenectomy for various indications were examined. These indications included hematologic disease in 38 patients and nonhematologic problems in 54. Of all the group foam cells were seen in hematoxylin and eosin (HE)-stained sections of spleens from 12 patients. This number increased to 21 (23%) when the diastase periodic acid-Schiff stain was used as a screening test. The cells in these 9 additional cases were too scanty to be observed on HE-stained sections alone. All the 21 spleens with positive foam cells were from patients with hematologic disease, specifically β-thalassemia major, hemoglobin S/β-thalassemia, hemoglobin AS, and idiopathic thrombocytopenic purpura. None of the spleens from the 54 nonhematologic patients showed foam cells. Factors that determine the probability of presence of foam cells were calculated. Also, certain differences in the staining reactions of foam cells were observed. The results of both, and the relation of these foam cells to the ‘syndrome of the sea-blue histiocyte’ are presented and disc
ISSN:0001-5792
DOI:10.1159/000205155
出版商:S. Karger AG
年代:1990
数据来源: Karger
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3. |
Comparative Effects of Busulfan, Cytosine Arabinoside and Adriamycin on Different Maturation Stages of Normal Human Bone Marrow Cells |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 16-21
Shuji Tohda,
Kaoru Nagata,
Toshiya Suzuki,
Nobuo Nara,
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摘要:
Leukemic blast progenitors in acute myeloblastic leukemia (AML) undergo terminal divisions and/or self-renewal, which can be studied by the methylcellulose culture method and suspension culture, respectively. Using these methods, we have shown that busulfan (BU) was more effective against the self-renewal of blast progenitors than against the terminal divisions. As reported previously, cytosine arabinoside (Ara-C) is more effective against self-renewal and adriamycin (ADR) is more effective against terminal divisions. To determine the reason why antileukemic drugs show different sensitivity against self-renewal and terminal divisions, we studied the effects of these drugs on normal human bone marrow cells. We have shown that BU and Ara-C suppressed the colony formation induced by interleukin-3 (IL-3) more effectively than that by granulocyte colony-stimulating factor (G-CSF). On the other hand, ADR suppressed the colonies induced by G-CSF more effectively. In normal hemopoiesis, IL-3 has been shown to stimulate the growth of more primitive hemopoietic stem cells, while G-CSF has been documented to stimulate the growth of granulopoietic committed precursors at a more differentiated stage. Therefore, BU and Ara-C are considered to be more effective against the immature cells in normal bone marrow and ADR is effective against the more differentiated cells. We suppose that the different differentiation stage of target cells may explain the difference of the effects on self-renewal and terminal divisions between BU, Ara-C and ADR.
ISSN:0001-5792
DOI:10.1159/000205156
出版商:S. Karger AG
年代:1990
数据来源: Karger
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4. |
Association of Neutrophil Alkaline Phosphatase Activity and Glycosylated Haemoglobin in Diabetes mellitus |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 22-25
N.B. Tsavaris,
G.A. Pangalis,
E. Variami,
A. Karabelis,
P. Kosmidis,
S. Raptis,
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摘要:
We determined neutrophil alkaline phosphatase (NAP) activity in diabetic patients in conjuction with HbA1c levels. NAP was estimated using semiquantitative cytochemical technique, and we studied its activity in different groups of diabetic patients. We found that NAP score is correlated with the HbA1c level. Non-diabetic patients were used as controls, in whom NAP score and HbA1c were found normal. In diabetic patients the NAP activity and the HbA1c level were altered similarly during the various phases of the disease. Our findings indicate that NAP score could be used as a simple new parameter for diabetes. The pathophysiologic mechanism of our observations needs further investigation.
ISSN:0001-5792
DOI:10.1159/000205157
出版商:S. Karger AG
年代:1990
数据来源: Karger
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5. |
Interleukin-2 Inhibits Growth of Fibroblasts Derived from Human Bone Marrow |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 26-30
D. MacDonald,
J.A. Adams,
D. McCarthy,
A.J. Barrett,
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摘要:
The adherent layer that forms in human bone marrow suspension cultures contains fibroblast colonies which arise from colony-forming cells (CFU-F). We have demonstrated that recombinant interleukin-2 (r-IL2) inhibits growth of CFU-F by preventing their entry into S phase. This inhibition is not mediated by γ-interferon, nor by T lymphocytes, and can be abrogated by anti-IL2 receptor antibody. r-IL2 may influence haematopoiesis by its effect on bone marrow CFU-F
ISSN:0001-5792
DOI:10.1159/000205158
出版商:S. Karger AG
年代:1990
数据来源: Karger
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6. |
Different Lymphocyte Activity in Patients with Polycythaemia vera Versus Secondary Polycythaemia and Healthy Blood Donors |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 31-34
F. Rueda,
A. Remacha,
F. Marti,
G. Piñol,
J. Soler,
C. Guañabens,
E. Gimferrer,
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摘要:
On comparing lymphocyte patterns in patients with polycythaemia vera (PV) versus healthy blood donors (NC) and patients with secondary polycythaemia (SP), we observed an altered CD4/CD8 ratio (p < 0.01) mainly due to the decreased CD8 subpopulation in PV. We found an increased lymphocyte activity in PV patients when compared with both SP and NC: the interleukin 2 (IL-2) production was significantly higher (p < 0.001) as was the lymphoproliferative response both to phytohaemagglutinin (p < 0.001) and IL-2 (p < 0.005). No significant differences were found between NC and SP. None of the PHA-stimulated PBMC samples from PV, SP or NC produced erythropoietin (EPO)-like or EPO-inhibitory activity. Our findings suggest an altered lymphoid lineage in PV patients.
ISSN:0001-5792
DOI:10.1159/000205159
出版商:S. Karger AG
年代:1990
数据来源: Karger
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7. |
Chronic Myeloid Leukaemia in Yorkshire: A Case Control Study |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 35-38
P.A. McKinney,
B.E. Roberts,
C. O'Brien,
C.C. Bird,
I.D.G. Richards,
F. Alexander,
R.A. Cartwright,
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摘要:
The results of a case-control study of chronic myeloid leukaemia in adults are reported. 122 cases and 241 controls were interviewed. Excess risks associates with heart disease and related drugs were revealed. In addition a weak association with occupational and/or hobby exposure to irradiation emerged.
ISSN:0001-5792
DOI:10.1159/000205160
出版商:S. Karger AG
年代:1990
数据来源: Karger
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8. |
A Case of the Unstable Hb Genova (β28 Leu → Pro) in an Arab Child Associated with Severe Haemolytic Anaemia and Growth Retardation |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 39-41
P. Hopmeier,
C. Binder,
H. Gadner,
M. Fischer,
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摘要:
The first case of unstable Hb Genova from North Africa is described. It was found in a 13-year-old girl from Libya suffering from chronic Heinz body haemolytic anaemia and growth retardation. The available data strongly suggest that this case represents a new example for a spontaneous mutation.
ISSN:0001-5792
DOI:10.1159/000205161
出版商:S. Karger AG
年代:1990
数据来源: Karger
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9. |
Sternal-Manubrial Separation as a Complication of Marrow Aspiration in a Patient with Protein-Calorie Malnutrition and Osteoporosis |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 42-44
Ted Eastlund,
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摘要:
A simple needle aspiration of marrow from the sternum was performed in a middle-aged woman with severe protein-calorie malnutrition and osteoporosis. Though carefully performed, a separation of the sternal-manubrial junction occurred with pain but no other serious sequelae. The subject of complications from marrow aspiration for diagnostic and therapeutic purposes is discussed.
ISSN:0001-5792
DOI:10.1159/000205162
出版商:S. Karger AG
年代:1990
数据来源: Karger
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10. |
Spontaneous Remission of Agnogenic Myeloid Metaplasia in a Splenectomized Patient: A Case Report with Erythrokinetic Studies |
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Acta Haematologica,
Volume 83,
Issue 1,
1990,
Page 45-48
Kazuyuki Shimizu,
Tomomitsu Hotta,
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摘要:
A 67-year-old woman with agnogenic myeloid metaplasia, who underwent splenectomy 1 year after the diagnosis, experienced spontaneous hematologic remission 6 years after splenectomy. Ten months before her anemia improved, peripheral leukocytes no longer showed a shift to the left and peripheral erythroblasts had disappeared. Sequential erythrokinetic studies revealed ineffective erythropoiesis with mild hemolysis and expansion of marrow activity in the tibia and femur but no erythropoiesis in the sacral or vertebral marrow.
ISSN:0001-5792
DOI:10.1159/000205163
出版商:S. Karger AG
年代:1990
数据来源: Karger
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