摘要:

The present investigations confirm and extend previous reports on the occurrence of cytochemical anomalies among the hemopoietic cells in preleukemia. The cytochemical patterns of the hemopoietic cells obtained from 19 patients suffering from a preleukemic disorder have been studied. The diagnostic value of the cytochemical examination using a panel of 10 different tests is emphasized. In a prospective study in 17 out of 25 patients, preleukemia had been correctly diagnosed. In 4 patients leukemia developed within 2–4 months from the diagnosis (‘imminent leukemia’), in 13 patients leukemia or smouldering leukemia developed between 4 and 25 months after the diagnosis (‘true preleukemia’). The cytochemical profiles of the hemopoietic cells of the latter have been compared with those of 14 patients suffering from aplastic anemia. In preleukemia the blasts did not exceed 3% of the nucleated bone marrow cells. The clinical value of the diagnosis ‘preleukemia’ is discussed as well as the prognosis and the possible therapeut

ISSN:0001-5792    

DOI:10.1159/000207739

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A morphological study using freeze-etching and scanning electron microscopy was carried out on lymphocytes from human peripheral blood. Freeze-etching electron microscopy of lymphocytes fractured at the level of the membrane shows the presence of two groups of cells according to their surface morphology: lymphocytes with a smooth surface and lymphocytes with a villous surface. Cells with surface features identical to the two types described by freeze-etching were also observed by scanning electron microscopy. Some lymphocytes with smooth surface showing uropods were also observed.

ISSN:0001-5792    

DOI:10.1159/000207740

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The unusual lymphocytes from a case of chronic lymphatic leukaemia are described in terms of surface morphology and ultrastructure. Surface blebs were found to consist of nuclear material surrounded by plasma membrane. On the information available it was not possible to determine whether these were due to cell motility or nuclear extrusion.

ISSN:0001-5792    

DOI:10.1159/000207741

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A patient taking diphenylhydantoin for 3 weeks developed a generalized skin rash, lymphadenopathy and pure red cell aplasia. After withdrawal of the pharmacon all symptoms disappeared spontaneously. Skin rash is a well-known complication of diphenylhydantoin treatment as is benign and malignant lymphadenopathy. Pure red cell aplasia associated with diphenylhydantoin medication has been reported in 3 patients. The exact mechanism by which diphenylhydantoin exerts its toxic effects is not known. In this patient the time relation between the ingestion of diphenylhydantoin and the occurrence of the skin rash, lymphadenopathy and pure red cell aplasia is very suggestive of a direct connection.

ISSN:0001-5792    

DOI:10.1159/000207742

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Erythroleukaemia in an elderly Caucasian male was associated with the presence of 15% of haemoglobin H (Hb-H; Hb-β4) in the haemolysate, identified by electrophoretic analysis, isolation and ‘finger-printing’. The peripheral blood picture was dimorphic, with 40% of hypochromic and morphologically abnormal red cells. Inclusion bodies indicative of the presence of Hb-H occurred in 30% of the red cells after supravital staining. The rare occurrence of Hb-H in leukaemic conditions and its distribution in the red cells is discussed in relation to the possible clonal origin of leukaemia and the involvement of red cell precur

ISSN:0001-5792    

DOI:10.1159/000207743

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Auto-immune haemolytic anaemia complicating infectious mononucleosis occurred in a patient with hereditary elliptocytosis. A cold antibody of IgM anti-i specificity with narrow thermal amplitude was identified in the serum and the erythrocytes were found to be coated with complement. Significantly excessive erythrophagocytosis was demonstrated in samples of the patient’s blood which had been chilled and then incubated at 37 °C. The patient recovered spontaneously. The elliptocytosis does not appear to have contributed to the episode of haemolytic anaemia; the other elliptocytic member of the family (her father) has no history and no present evidence of haemolys

ISSN:0001-5792    

DOI:10.1159/000207744

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A case of congenital malformations of the extremities (deformed thumbs and great toes, dislocation of the hips, limitation of motion of the joints of the lower extremities), bilateral microphthalmia, bilateral retinal cysts, cerebral atrophy epilepsy, severe physical and mental retardation and monolobed neutrophil granulocytes is reported. A similar clinical picture has not previously been described. We assume that the patient suffers from a sublethal genetic disorder.

ISSN:0001-5792    

DOI:10.1159/000207745

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207746

出版商:S. Karger AG    

年代:1978

数据来源: Karger