摘要:

23 patients with aregenerative anemia from the hematology section at the Karolinska Hospital were followed. The patients were divided into 3 groups; those with a hypocellular marrow, those with a hypercellular marrow and those with marrow fibrosis. Mostof the patients with hypocellular marrow had granulocytopenia, but no thrombocytopenia, and they did not develop leukemia. The group of patients with hypercellular marrow had no granulocytopenia, but thrombocytopenia and sideroblastosis, and they often developed leukemia. It seems justified to look upon aregenerative anemia with hypercellular marrow and sideroblastosis as a preleukemic state. The change in cellular metabolism (sideroblastosis, possible prolongation of generation time) preceded the leukemia by several years, but the cellular differentiation appeared normal prior to leukemia development. The sideroblastosis may be related to the early changes in iron metabolism previously demonstrated in cancer patients.

ISSN:0001-5792    

DOI:10.1159/000208490

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Treatment of aplastic anaemia in 28 patients with oral methenolone 1–2 mg/kg for from 2 to 12 months resulted in normalisation of the blood count in 12 cases (43%). The remission rate was 60% for patients with a treatment period of at least 3 months. Cholestatic jaundice occurred in 2 cases (7%) but these recovered after discontinuing the drug. Other side effects were not severe enough to cause interruption of the treatment. There seems to be no doubt that methenolone by mouth is a useful treatment of patients with aplastic anaemia. The trial of therapy should be extended to at least 6 month

ISSN:0001-5792    

DOI:10.1159/000208491

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

In a 13-year-old patient with acute leukaemia the leukaemic blast cells, the nucleated red cells and the megakaryocytes were studied by cytophotometrie determination of the DNA content and autoradiographic labelling with 3H-TdR invitro. In the preleukaemic phase a striking proliferation defect in the early polychromatic erythroblasts was observed, consisting of an accumulation of cells in G1 and a decreased proportion of cells in S. In the megakaryocytes low DNA values from 2c-8c as compared to 4c-32c in normal megakaryocytopoiesis, and a decreased number of labelled cells between the ploidy stages was observed, indicating a severely restricted polyploidization capacity. These results suggest that in the preleukaemic stage a basic proliferation defect of acute leukaemic is becoming apparent in the so-called non-leukaemic cell systems, leading to peripheral mono- or pancytopenia.

ISSN:0001-5792    

DOI:10.1159/000208492

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

In 3 patients with dysproteinaemia the defects in haemostasis were investigated: Waldenström’s macroglobulinaemia, macroglobulinaemia associated with undifferentiated malignancy in the marrow, diffuse hypergammaglobulinaemia associated with drug sensitive purpura. Platelet factor 3 release, reduction of its total contents and poor platelet adhesion were found in all 3 patients. Platelet aggregation was absent in 2 patients who had macroglobulinaemia with monoclonal spike. It is suggested that the platelet factor 3 assay may be of value in the investigation of these changes in relation to dysproteinaemi

ISSN:0001-5792    

DOI:10.1159/000208493

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Hemoglobin J Paris (α12 Ala→Asp) was found in 2 unrelated families in Iran during a survey among hospitalized patients. No erythrocytosis or leukocytosis were present in the heterozygous carriers, contrary towhat was abserved in the first case in France. A modified technique is given for the preparation of the peptide chains of Hb

ISSN:0001-5792    

DOI:10.1159/000208494

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Single oral doses of 100 mg/kg T to rats caused marked lymphopenia. Recovery started after 12 h and was accompanied by depletion of small lymphocytes in lymph follicles of the spleen and the appearance of young lymphocytes with vacuoles and basophil granules in smears of lymph nodes and spleen. Abnormal mononuclear cells whose protoplasm often contained vacuoles and basophil granules appeared in the blood after 48 h. They disappeared in the course of 2–3 weeks. The granulocytic system responded to T with a short-lasting leukocytosis, a shift to left and appearance of basophil granules in neutrophil and eosinophil promyelocytes and myelocytes. Repeated administration of T caused only minor hematologic changes. No other organs were affected by the dru

ISSN:0001-5792    

DOI:10.1159/000208495

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Using the iso-electric focusing technique, microheterogeneity of normal rabbit ferritin has been demonstrated. The iso-electric points of the sub-fractions are 5.18, 5.15, 5.00 and 4.95. Evidence for the existence of a variant of normal rabbit ferritin is presented and the value for the iso-electric point of this abnormal ferritin is4.46.

ISSN:0001-5792    

DOI:10.1159/000208496

出版商:S. Karger AG    

年代:1972

数据来源: Karger