摘要:

Decreased actinomycin D binding was observed in the marrow cells of some patients with chronic myeloid leukaemia. Blast uptake was still reduced in 2 cases of blast crisis and in acute myeloblastic leukaemia. However, the differentiating cells in blast crisis, i.e., those that had passed the blast stage, had exactly the same actinomycin D binding values as normal myeloid cells. After 0.5 mg/kg methotrexate, increased actinomycin D binding on the part of the entire leukaemic population was observed in one case of acute myeloblastic leukaemia. These findings suggest differences in chromatin behaviour and genetic activity in myeloid cells in the different stages of myeloid leukaemia.

ISSN:0001-5792    

DOI:10.1159/000208269

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

An attempt was made to study the relationship between secondary anemia and the reticuloendothelial uptake in 18 patients with cancer. The RE up- take of colloidal radiogold was significantly more rapid in the patients than in the controls; so was the plasma clearance of radioiron even though there was not any statistically significant anemia. The gold and iron clearances were significantly correlated to each other, and to the erythrocyte sedimentation rate. The results are considered to be compatible with the hypothesis that cancer anemia may be caused, e.g., by RE uptake of some erythropoietic substances and of erythrocytes.

ISSN:0001-5792    

DOI:10.1159/000208270

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

In hemolytic anemia, acute hemorrhagic anemia and β-thalassemia, transformation of stem cells into morphologically identifiable, red cell precursors, already yields, in part, smaller erythroblasts during a brief G1-phase. The interphasic RNA influx into the cytoplasm is increased in hemolytic and hemorrhagic anemias and diminished in β-thalassemia. In hemolytic anemia and acute hemorrhagic anemia, interphasic hemoglobin synthesis occurs in young erythroblasts as in normal erythropoiesis; it is reduced to one-half in thalassemia. In the cases examined, the ‘critical hemoglobin concentration’ is lower in the G2-phase erythroblasts than in normal erythropoiesis, and frequently reached in young erythroblasts. Thus, the number of maturation stages is re

ISSN:0001-5792    

DOI:10.1159/000208271

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Supravital staining with crystal violet of normal erythrocytes which had been exposed to hydrogen peroxide vapour, resulted in the appearance not only of Heinz bodies but also in an overall blue coloration of a proportion of the erythrocytes. Inhibition of catalase by aminotriazole or by sodium azide greatly increased the proportion of such ‘blue cells’. A close relationship was found between the percentage of ‘blue cells’ and the degree of lipid peroxidation as measured by malonyldialdehyde fo

ISSN:0001-5792    

DOI:10.1159/000208272

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Data are reported pertaining to the 57 subjects so far found to be heterozygotes for the abnormal factor X (factor X Friuli) coagulation disorder. 41 of these subjects were related to the 11 patients known to be homozygote for the defect. Their average factor X level was 59.7%. The difference between such an average and those found in the homozygote population (10.9%) and in two normal groups (106 and 103%) was statistically significant. The heterozygote usually presents a 1-to 2.5-sec prolongation of the prothrombin time. A significant negative correlation was found to exist between the prothrombin time prolongation in seconds and the percentile factor X level. Factor X in the heterozygote population results to be lower when assayed using human brain or human placenta thromboplastins as compared with a rabbit brain and lung thromboplastin. The cross-over electrophoresis mobility of heterozygote Friuli plasma is identical to that of homozygote Friuli plasma and normal plasma. About one third of the heterozygote patients presented bleeding manifestations.

ISSN:0001-5792    

DOI:10.1159/000208273

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A patient with hereditary elliptocytosis and pernicious anaemia is described. After the treatment with hydroxocobalamin the patient’s clinical condition and blood picture became entirely normal, except the persistence of elliptocytes of hereditary origin. Gene interaction was not encountere

ISSN:0001-5792    

DOI:10.1159/000208274

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A case is reported of primary hemorrhagic syndrome produced by a functional defect of platelets due to an extrinsic cause, being associated with a decrease of all blood lipid fractions, particularly of phosphatidylcholine and with an absence of phosphatidylethanolamine. The possible relationships between the two alterations are discussed.

ISSN:0001-5792    

DOI:10.1159/000208275

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208276

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000208277

出版商:S. Karger AG    

年代:1974

数据来源: Karger