摘要:

A number of individuals in the population, including healthy blood donors and patients on methyldopa, show evidence of erythrocyte coating by IgG autoantibodies (positive direct Coombs’ test) without signs of a haemolytic state. The readiness with which red cells from these subjects are taken up by normal human monocytes in short term culture was examined, and compared with the phagocytosis of red cells from cases of IgG-mediated haemolytic anaemia. Red cells from nonhaemolysing subjects were as avidly ingested in this system as were red cells from haemolysing patients. Similar results were obtained using normal red cells sensitised with autoantibody eluted from the cells of a healthy blood dono

ISSN:0001-5792    

DOI:10.1159/000207987

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a major cause of severe neonatal jaundice in Nigeria, but not all G6PD-deficient babies become jaundiced. Neonatal jaundice not attributable to G6PD deficiency nor to any other known aetiology is also common. In an effort to explain these two facts, we have measured the levels of the three enzymes G6PD, glutathione peroxidase (GSHPX), and glutathione reductase (GSSGR) in 38 jaundiced newborns, 26 control newborns, and 44 normal adults, all of them males. We could not yet prove an additive effect of GSSGR or GSHPX deficiency with G6PD deficiency in causing jaundice. There was no evidence that low levels of GSHPX per se are associated with jaundice. However, jaundiced newborns with normal G6PD had significantly lower levels of GSSGR than control newborns with normal G6PD. These data suggest that a relatively low activity of GSSGR, a riboflavin-dependent enzyme, may predispose the red cells to accelerated destruction in the neonatal period.

ISSN:0001-5792    

DOI:10.1159/000207988

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Coagulation studies were performed in 61 patients of acute infective hepatitis. 18 with clinical signs of liver failure had bleeding and all succumbed. The 47 patients without liver failure showed no haemorrhagic diathesis and all of them had uneventful recovery. Though coagulopathy was present in most of the patients, the severity and frequency of coagulation defects were more in those with signs of hepatic failure. Hypofibrinogenemia, elevated serum fibrinogen degradation products and accelerated euglobulin lysis were conspicuous in patients with hepatic failure. It appears that while diminished synthesis of coagulation factors is the main basis for coagulopathy in patients without hepatic failure, additional factors like local or disseminated intravascular coagulation and increased fibrinolysis also contribute significantly to the coagulopathy in cases of liver failure.

ISSN:0001-5792    

DOI:10.1159/000207989

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Young adult BD-IX rats made leukemic by intravenous infusion of 2×10τ nucleated blood cells from leukemic donors (L 5222), showed lesions in the central nervous system 6 days after transfer when their leukocyte count was between 250,000 and 350,000 cells/μl. The brain was affected in only half of the animals, whereas all showed an infiltration of the meninges. Furthermore, all animals had extensive lesions in the spinal cord. The lesions consisted of nodules of leukemic cells and hemorrhages which were predominant in the lower half of the spinal cord and more abundant in the white than in the gray matter. Paraplegia appeared in some animals shortly before death. Since there is a consistent involvement of the meninges and spinal cord, the L 5222 leukemia seems to be a useful model for the study of leukemic infiltration of the central nervous system and the reaction to chemothera

ISSN:0001-5792    

DOI:10.1159/000207990

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The frequency of α-thalassaemia has been determined by the analysis of Hb Barts in 650 newborns; 4.46% of them showed high levels of Hb Barts. The incidence of newborns with different levels of Hb Barts (1–2, 5 and 25%, respectively) and the frequency of the α-thalassaemia genes are also gi

ISSN:0001-5792    

DOI:10.1159/000207995

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Study of a large Anglo-Saxon family with -thalassaemia trait revealed evidence of consanguinity, moreover both branches of the family shared a Spanish ancestor. The manifestations of the disorder were varied in severity and yet the degree of severity appeared to breed true within any individual part of the family. Our explanation for the inheritance pattern observed in the family was to postulate the existence of two non-allelic genes influencing the rate of β -chain synthesis

ISSN:0001-5792    

DOI:10.1159/000207991

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A woman with symptoms of prolonged post-traumatic bleeding was found to have a severe defect of factor XI, and was thought to be homozygously affected. Both her parents, who were first cousins, and all her three children, though asymptomatic, showed a moderate defect and appeared to be heterozygous. Both her parents’ factor XI levels were about twice those in her children, and this was thought to be an age effec

ISSN:0001-5792    

DOI:10.1159/000207992

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A 64-year-old man with multiple sclerosis developed a circulating anticoagulant. Three immunoglobulin fractions (I = IgG; II = IgG+IgA; III = IgM) were separated from patient serum by 33-percent ammonium sulfate precipitation and DEAE-52 cellulose column chromatography. Fractions I (IgG) and II (IgG + IgA) had factor VIII inhibitory activity on incubation. Fraction I (IgG) possessed, in addition, immediate anti-IX activity which did not require incubation. Absorption studies characterized the VIII inhibitors as IgG-χ in fraction I and IgG-χ+IgG-λ in fraction II. Immediately reactive IgG anti-IX antibodies associated with kinetically distinct IgG anti-VIII antibodies have not been described previous

ISSN:0001-5792    

DOI:10.1159/000207993

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The case is presented of a patient, treated for Hodgkin’s disease, who contracted infectious mononucleosis more than 3 years later. While Epstein-Barr virus has been considered a possible etiologic factor in Hodgkin’s disease, the sequence of events reported in this case has to be interpreted as evidence against a causal relationship between the virus and Hodgkin’s disease in this pa

ISSN:0001-5792    

DOI:10.1159/000207994

出版商:S. Karger AG    

年代:1976

数据来源: Karger