摘要:

The value of systematic laparoscopy for the definition of the illness stage in every case of initial Hodg- kin’s disease is show

ISSN:0001-5792    

DOI:10.1159/000208379

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Perturbations of the generation cycle of human leukemic myeloblasts in vivo by cytosine-arabinoside were studied by in vitro labeling of human bone marrow with tritiated thymidine. Ten patients with myeloblastic acute leukemia at onset of the disease or in relapse received a 4-h infusion of the drug. Mitotic and labeling indexes were calculated before and after chemotherapy. A kinetic pattern indicating a specific action of the drug on the S-phase lasting about 20 h was found. A secondary increase of the labeling index beginning 24 h after treatment was observed. The results suggest a synchronization of the blastic cells in cycle 48 h after cytosine-arabinoside injection.

ISSN:0001-5792    

DOI:10.1159/000208380

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Parietal cell antibody, vitamin B12 andpepsinogen in serum were measured for the investigation of prevalence of pernicious anaemia amongst Indians in the Delhi area in India. Low levels of serum pepsinogen were observed in age groups 11–20and 41–50 years, and low levels of serum pepsinogen appear to occur with greater frequency in vitamin B12 deficient subjects. The significance of these findings in relation to the prevalence of pernicious anaemia is discus

ISSN:0001-5792    

DOI:10.1159/000208381

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Newborns were examined for the presence of slow-moving haemoglobin components, tentatively designated X components and previously found in a group of Hb H disease in which invariably one of the parents of each patient had the same slow-moving Hb X components also. Structural studies showed that the abnormal haemoglobin in Chinese was. identical with Hb Constant Spring, an α-chain variant. Newborns with Hb Bart’s and slow-moving X components invariably had one parent with the X components also. When the child grew older Hb Bart’s disappeared while the Hb X components remained in the blood. The homozygous state for the X components was found in a Malay boy through his newborn brother who had the X components in addition to Hb Bart’s and had both parents with the X components. One other Malay baby had the X components and Hb A2 Indonesia inherited from the parents. The present study of newborns also showed that Hb Bart’s can accompany different abnormalities of haemoglobin production, involving α-chains, β-chains as well as γ-chains. Its presence in cord blood is, therefore, not specific for α-

ISSN:0001-5792    

DOI:10.1159/000208382

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The reaction of normal haemopoiesis under the development of a transferable acute leukaemia was studied in the rat. A reduction of cell numbers was observed in the bone marrow in the proliferating compartments of erythropoiesis, megakaryocytopoiesis and myelopoiesis. In the peripheral blood, erythrocyte and platelet levels decreased to one tenth of normal: Granulocytes and lymphocytes showed an increase coincident with the increase in circulating leukaemic cells before a final tendency to decline. These changes are attributed partly to variations in the inflow from the bone marrow and partly to direct effects on the peripheral blood cells themselves. The reduced number of cells in the proliferation compartment may be brought about by effects on this compartment itself, but there are some indications that a reduced inflow from the preceding stem cell compartment might be responsible.

ISSN:0001-5792    

DOI:10.1159/000208383

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

During interaction in vitro of syngenic platelets from healthy mice with HIPA ascitic plasmacytoma, clot formation was slower than during interaction of syngenic platelets from HIPA tumor-bearing mice with HIPA plasmacytoma. The platelet aggregates were composed, in both cases, of ‘balloon platelets’ and tumor cells. The granulated part of the ‘balloon platelets’ made up the centre, whereas granule-free spheroids were seen at the periphery of the aggregates. To contact with platelets, the tumor cells reacted with formation of microvilli, condensation of mitochondria and phagocytosis of the granule-free spheroids. No formation of pseudopodia by platelets in contact with the tumor cells was o

ISSN:0001-5792    

DOI:10.1159/000208384

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In vivo studies were made of the effect of a single (1 mg) dose of phytohaemagglutinin (PHA) on haemopoiesis in young female adult mice over a period of 20 days. The results show that PHA stimulates erythroid cells to divide but produces many nuclear abnormalities. It is suggested that these abnormalities may account for a poor reticulocyte response and the absence of any increase in the number of circulating erythrocytes. An attempt is made to correlate these results with the results of PHA treatment of patients with aplastic anaemias.

ISSN:0001-5792    

DOI:10.1159/000208385

出版商:S. Karger AG    

年代:1973

数据来源: Karger