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1. |
T-ALL Related to Intermediate Cortical/Medullary Thymocytes Displaying Functional and Surface Characteristics of Suppressor T Cells |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 1-7
F. Herrmann,
G. Sieber,
B. Komischke,
R. Oestreich,
H. Rühl,
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摘要:
Leukemic cells of a patient with acute T-lymphoblastic leukemia (T-ALL) exhibiting the uncommon clinical feature of hypogammaglobulinemia were examined in terms of surface markers and immunologic functions. Employing various monoclonal reagents reacting with surface antigens present on T cells and additional conventional markers, it was shown that the patient’s leukemic cells expressed a phenotypical profile (E-R+, TdT+, C3d-R-, OKT 3-, T 4-, T 6(+), T 10+, T 8 ++) corresponding to the intermediate stage between the cortical and medullary phase of normal thymocyte differentiation. Functionally, they were unable to respond to mitogens or to produce detectable amounts of immunoglobulins or to provide ‘help’ for allogeneic antibody production while they suppressed the immunoglobulin production of normal B cells by 76% in coculture experi
ISSN:0001-5792
DOI:10.1159/000206496
出版商:S. Karger AG
年代:1984
数据来源: Karger
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2. |
Measurements of Nuclear Sizes of Committed Hematopoietic Progenitor Cells Compared to Leukemic Blasts from Human Bone Marrow Smears |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 8-12
I.T.M. Boll,
C. Domeyer,
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摘要:
By measurements of the nuclear sizes of normal and of leukemic myeloblasts and monoblasts in colored smears, the differences estimated in surviving cells with phase contrast were confirmed. The median nuclear size of normal myeloblasts is the smallest one and differs significantly from that of the normal monoblasts and AML myeloblasts. The median nuclear size of normal monoblasts significantly exceeds values of normal myeloblasts and of AMoL monoblasts. Both leukemic blasts cover a wide range of nuclear diameters, but do not differ from one another, while normal myeloblasts have a smaller dispersion than normal monoblasts. The difference of leukemic blasts and normal progenitor cells is to be emphasized.
ISSN:0001-5792
DOI:10.1159/000206497
出版商:S. Karger AG
年代:1984
数据来源: Karger
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3. |
Technetium 99m Autoradiography of Labelled White Cells |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 13-17
Marianne Barbu,
Nicole Colas-Linhart,
B. Bok,
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摘要:
The cellular uptake of technetium 99m was determined on white blood cells (WBC) by autoradiography, after ‘cold’ tin pyrophosphate prelabelling followed by pertechnetate labelling. The autoradiographic method gave visible tracks of 99mTc internal conversion and Auger electrons. 75 ± 5% of the treated WBC were labelled but none of the control WBC. The number and length of tracks per cell varied greatly. This was perhaps due to imaging conditions as well as to variations in cell up
ISSN:0001-5792
DOI:10.1159/000206498
出版商:S. Karger AG
年代:1984
数据来源: Karger
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4. |
Evaluation of the Use of the Hemalog D in Acute Lymphoblastic Leukaemia and Disseminated Non-Hodgkin’s Lymphoma in Children |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 18-24
E. Cranendonk,
N.G.G.M. Abeling,
A. Bakker,
M.E. de Jong,
A.H. van Gennip,
H. Behrendt,
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摘要:
In 79 children with acute lymphoblastic leukaemia and in 18 children with disseminated non-Hodgkin’s lymphoma we investigated whether the automated cyto-chemical differential leucocyte count (Hemalog D) gives more accurate information than the manual differential count. We concluded that the manual count is superior to the Hemalog-D count with regard to the recognition of blast cells. Furthermore, Hemalog D is not helpful for the differentiation between acute lymphoblastic leukaemia and disseminated non-Hodgkin’s lymph
ISSN:0001-5792
DOI:10.1159/000206499
出版商:S. Karger AG
年代:1984
数据来源: Karger
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5. |
Discriminant Study of Platelet Volume Indices in the Etiological Diagnosis of Thrombocytopenia |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 25-31
M. Dumoulin-Lagrange,
M. Tirmarche,
B. Couston,
M. Hotchen,
M. Samama,
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摘要:
Platelet volume distribution was examined in 47 thrombocytopenic subjects with a platelet count between 20 109 and 150 109/1. Thrombocytopenia was attributed to defective production in 19 cases (12 acute leukemia) and to accelerated destruction in 28 cases (27 idiopathic thrombocytopenic purpura). Six volume variables were retained from the platelet volume distribution curves. A multivariate discriminant analysis has shown that the median of the curves was the most discriminant parameter between the two types of thrombocytopenia: the value of the median was less than 7 μm3 in 89.5% of patients with defective platelet production and greater than 7 μm3 in 85.7% of those with excessive platelet destruction. Thus, platelet volume measurement and the median value in particular allows a rapid orientation of the etiological diagnosis of thrombocytopeni
ISSN:0001-5792
DOI:10.1159/000206501
出版商:S. Karger AG
年代:1984
数据来源: Karger
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6. |
Clinical Significance of Beta-Thromboglobulin in Patients with High Platelet Count |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 32-38
Fabrizio Fabris,
Maria Luigia Randi,
Alessandra Casonato,
Renzo Dal Bo Zanon,
Pietro Bonvicini,
Antonio Girolami,
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摘要:
The aim of the study was to investigate the relevance of β-thromboglobulin (β tg) measurement in patients with thrombocytosis. We have, therefore, studied the level of plasma and platelet βtg in 74 patients with high platelet count in addition to the evaluation of platelet aggregation and platelet serotonin (5-HT) content. The determinations of platelet serotonin content and aggregation are confirmed to be useful in the differentiation between primary and secondary forms of thrombocytosis. The mean plasma level of βtg in patients with myeloproliferative disease was significantly raised, but the amount observed in subjects with secondary thrombocytosis is increased too. Considering the amount of βtg in relation to whole blood platelet count (βtg ratio), no difference was observed between all patients and controls. The βtg ratio allowed the identification of a group of patients with an increased ratio and a decreased βtg platelet content who showed the highest occurrence of thrombosi
ISSN:0001-5792
DOI:10.1159/000206503
出版商:S. Karger AG
年代:1984
数据来源: Karger
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7. |
Enumeration of Circulating Ferritin-Secreting Cells by a Reverse Hemolytic Plaque Assay |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 39-44
Kazunori Ohnishi,
Kazuyuki Shimizu,
Hideo Yamada,
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摘要:
In the present study, we tried to detect ferritin-secreting cells (FSC) as plaque-forming cells using a reverse hemolytic plaque assay and thereby to evaluate some of the cellular aspects of ferritin dynamics associated with various hematological disorders. Healthy adult males had 433 FSC and adult females had 244 FSC in 1 × 105 peripheral blood mononuclear cells (PBM). The mean numbers of FSC in 1 × 105 lymphocyte-enriched fraction were 120 in males and 53 in females, and those in 1 × 105 monocyte-enriched fraction were 932 in males and 668 in females. These results indicate that monocytes contain about 8–13 times as many FSC as lymphocytes. Each fraction of PBM from patients with iron deficiency anemia contains only about half as many FSC as those of normal individuals. Whereas, in states of increased iron storage such as seen in sideroblastic anemia, aplastic anemia and myelofibrosis, the mean numbers of FSC are markedly increased to about 4–8 times in PBM, about 11–20 times in lymphocytes and about 3–7 times in monocytes, compared with each counterpart of the normal i
ISSN:0001-5792
DOI:10.1159/000206504
出版商:S. Karger AG
年代:1984
数据来源: Karger
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8. |
C3 Polymorphism in Beta-Thalassemia |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 45-48
A. Germenis,
M. Kalantzi,
A. Karamerou,
C. Politi,
A. Fertakis,
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摘要:
The distribution of phenotypes and gene frequencies of the third component of complement (C3) were studied in 106 β-thalassemic patients and in 112 carriers of the β-thalassemia trait. A statistically significant association was found between the C3F gene and homozygous β-thalassemia. It can be suggested that this association may be related with the high incidence of infections encountered in these patien
ISSN:0001-5792
DOI:10.1159/000206507
出版商:S. Karger AG
年代:1984
数据来源: Karger
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9. |
Acquired Factor IX Inhibitor in a Patient with Adenocarcinoma of the Colon |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 49-52
Wade Collins,
Francisco Gonzalez,
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摘要:
The association of an acquired inhibitor to factor IX and adenocarcinoma of the sigmoid colon is reported here for the first time. Unlike the lupus anticoagulant, the inhibitor identified did not exhibit marked prolongation of the clotting time using a highly diluted thromboplastin nor was the kinetic behavior of the inhibitor-factor IX interaction time-dependent. Administration of prednisone was associated with the return of the activated partial thromboplastin time to normal values, at which time the tumor was excised and corticosteroids discontinued with no evidence of subsquent factor IX inhibitor activity.
ISSN:0001-5792
DOI:10.1159/000206509
出版商:S. Karger AG
年代:1984
数据来源: Karger
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10. |
Sequential Development of Waldenström’s Macroglobulinemia and Gamma-1-Heavy Chain Disease in a Single Patient |
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Acta Haematologica,
Volume 71,
Issue 1,
1984,
Page 53-59
T. Ockhuizen,
J.F. Jilderda,
T. Cazemier,
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摘要:
The present paper deals with the rare phenomenon of the sequential development of Waldenström’s macroglobulinemia (WM) and γ1 heavy chain disease (γ1-HCD) in a single patient. The coexistence of both monoclonal proteins lasted for more than 9 years. Serial determinations were made of serum levels of IgM, IgA, intact IgG, and the γ-HCD protein. Immunofluorescent studies of a bone marrow aspirate confirmed the diagnosis of an IgM(κ) monoclonal gammopathy and also showed cells which were thought to synthesize the γ-HCD protein. The molecular weight of the γ-HCD protein was 60,000 in the dimeric form. It is concluded that the original IgM(eκ) monoclonal gammopathy predisposed the patient for a second lymphoproliferative disorder (the γ-HCD) and that both monoclonal proteins are immunogenetically
ISSN:0001-5792
DOI:10.1159/000206510
出版商:S. Karger AG
年代:1984
数据来源: Karger
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