摘要:

Sequential studies in acute myeloid leukemia of bone marrow cells in agar culture showed striking fluctuations of colony and cluster formation during induction of remission. These oscillations may be initiated by recruitment of resting leukemic and normal cells upon chemotherapeutic perturbation. Striking oscillations of the colony and cluster formation occurred also during remission with or without maintenance therapy, but with a longer periodicity as compared to the phase of induction of remission. Oscillations of the marrow growth capacity during remission may reflect potential relapses where the outcome depends on proliferative advantages of the normal or leukemic cell clone.

ISSN:0001-5792    

DOI:10.1159/000207581

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A 45-year-old female developed blastic metamorphosis in chronic granulocytic leukaemia after 52 months of chronic phase. During the subsequent 6–7 months, lymphosarcomatous enlargements of various lymph nodes developed. The blast cells in lymph nodes differed morphologically from those in bone marrow and blood, being ‘lymphoid’ non-B, non-T, non-ALL cells. The karyotype of all metaphases from one lymph node was 47, XX, +21(Ph1+) being identical to the karyotype of medullary cells. However, the karyotype of all blasts from another lymph node was 47, XX, + mar(Ph1+). It is likely that the local micro-environment controlled the clonal differentiation of these subpopulations which had originated from the same Ph1-positive multipotent stem cell. In lymph nodes and other extramedullary sites blasts were primitive without differentiation, but a myeloid differentiation in the bone marrow was demonstrated morphologically and cytochemi

ISSN:0001-5792    

DOI:10.1159/000207582

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Three patients with malignant histiocytosis treated with combination chemotherapy are reported. Induction treatment included bleomycin, adriamycin, cyclophosphamide, vincristine and prednisone (BACOP). Complete response was obtained in one patient who is alive and well 32 months after diagnosis. A partial response was obtained in the second patient, who is alive and well 35 months after diagnosis. The third patient died with drug-induced agranulocytosis and sepsis.

ISSN:0001-5792    

DOI:10.1159/000207583

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A case of nonproductor myeloma is reported. The diagnosis was supported by the radiological findings, the heavy marrow infiltration of malignant plasma cells, the absence of a monoclonal component in the serum or urine and the failure to demonstrate intracytoplasmic immunoglobulins with immunofluorescent techniques. The clinical findings of our patient are similar to those reported for the 5 cases of nonproductor myeloma described so far, indicating that there are no characteristic features differentiating nonproductor myeloma from productor myelomas.

ISSN:0001-5792    

DOI:10.1159/000207584

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

85 patients with previously untreated Hodgkin’s disease with stage I, II A and B nodular sclerosis were treated. 31 of them with stage I and II A were submitted to radiotherapy alone. All are alive, but 9 of them (30%) relapsed. On the contrary, 35 patients with stage I and II A, and 19 with stage I, II and IIE B were submitted to radiotherapy followed by three courses of MOPP. All 54 patients are alive and relapse-free. No severe complication related to chemotherapy was observed. The analysis of results suggests that 3 courses of MOPP can significantly (p < 0.00025) reduce the relapse rate in patients with stage I and II nodular sclerosis, eligible for radiotherapy, without increasing morbidit

ISSN:0001-5792    

DOI:10.1159/000207585

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

In view of the reported associations of Hodgkin’s disease and ferritin, an electron microscopic study of the peripheral blood lymphocytes of these patients was done. In 5 out of the 6 patients studied intracellular ferritin deposits were seen. No such deposits were seen in the lymphocytes of healthy subjects or in those of a patient with β-thalassemia. The lymphocyte ferritin accumulation in Hodgkin’s disease can arise either from increased synthesis or from phagocyt

ISSN:0001-5792    

DOI:10.1159/000207586

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Serum ferritin measured at birth in 69 low birth weight infants proved to vary with gestational age as well as with weight. The increase with gestational age was even more striking when the infants small for gestational age were excluded. The relation between maternal and infant serum ferritin concentration was investigated for 2 groups of infants and their mothers (preterm and term infants, respectively). Neither in preterm nor in term infants was the serum ferritin found to vary with that in the respective mothers.

ISSN:0001-5792    

DOI:10.1159/000207587

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Lipids and protein-containing nonlipids of pig erythrocytes, serum and several organs were tested for A blood group activity. Both lipids and nonlipids of brain, myocardium, skeletal muscle and adipose tissue show no A activity. The way of distribution of A activity on lipids and nonlipids of other tissues and serum differs among individual pigs. With respect to the acquisition of A activity of erythrocytes in a postnatal period, it seems likely that the lipidic A substance (or part of it containing the A determinant) is transferred from plasma to the erythrocyte membrane.

ISSN:0001-5792    

DOI:10.1159/000207588

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A rare case of acute promyelocytic leukemia (APL) is reported in a 7-year-old boy. The patient displayed the typical features of APL including impaction of the marrow with promyelocytes, marked elevation of the serum vitamin B12 and transcobalamin I levels and a hemorrhagic diathesis. The bleeding diathesis in this case was due to thrombocytopenia, and there was no evidence for disseminated intravascular coagulation.

ISSN:0001-5792    

DOI:10.1159/000207589

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0001-5792    

DOI:10.1159/000207590

出版商:S. Karger AG    

年代:1979

数据来源: Karger