摘要:

ABSTRACTThe aim of this study was to demonstrate acute efficacy of photodynamic therapy on atheromas by using a pheophorbide derivative, PH-1126. Cholesterol-fed atherosclerotic rabbits were injected intravenously with 1 mg/kg of PH-1126. Twenty-four hours later, PH-1126 selectively accumulated in atherosclerotic plaques. Then, atherosclerotic lesions in the upper thoracic aorta were treated by irradiation with a krypton ion laser at a wave-length of 647 nm. At 6 h after photodynamic therapy, the treated aorta was examined by scanning electron microscopy. Numerous teardrop-shaped cells were observed on the endothelial surface of the plaque irradiated at a total energy of 100 J/cm2. These cells were larger than monocytes and macrophages, and resembled foam cells in size and shape. The body of the teardrop-shaped cell resembled pumice stone, mainly because of the presence of globular elements in the cytoplasm. A part of the cell appeared to remain in the subendothelial space. These findings suggest that the cells may be foam cells from the intimal layer of atherosclerotic plaque that were expelled into the aortic lumen. It may become possible to flatten atheroma in a long-term period after photodynamic therapy using PH-1126 as a potent photosensitizer.

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.1

年代:1996

数据来源: MAL

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.7

年代:1996

数据来源: MAL

摘要:

ABSTRACTImmediate correction of neurologic deficits due to herniated disc disease following percutaneous laser disc decompression (PLDD) has not previously been reported. In a review of 182 cases of herniated intervertebral disc disease with radicular pain syndromes, the author observed a high percentage of return of absent ankle and knee jerk reflexes, return of straight leg raising to normal, and a change of the characteristic rolling to one side, bending the knees, and propping up with the hands as the usual maneuver to change from a supine to a sitting position ("Choy sign") to an ability to sit up directly by trunk flexion, immediately, and at 1 day after PLDD. The neurophysiologic implications are discussed.

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.13

年代:1996

数据来源: MAL

摘要:

ABSTRACTThe detoxification and sterilization radicular surfaces that have been produced by periodontal diseases could be accomplished after polishing (root planing) using the thermal elevation resulting from CO2laser on continuous emission.In vitroexperiments reveal that thermal elevations reached on the surfaces or in the depth are proportional to the dispersed energy. The thermal elevation in the depth (0.5–1 mm from the impact point) remained moderate because of the water absorption potentials of the radiations. Energies from 2 to 4.5 J can help obtain the combination of surface temperature elevation, which allows detoxification, and of a thermal elevation in the depth, compatible with vital tissues. This energy has to be delivered at an application time under 0.6 sec in continuous mod

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.17

年代:1996

数据来源: MAL

摘要:

ABSTRACTWe report a technique for treatment of pulmonary tuberculosis that has become resistant to traditional antibiotics. We introduce a needle into the lung that carries the N2laser to the affected chest cavity. It is irradiated for 10 min and usually only one sitting is required. Clinical improvement occurred in 90% of the patients; 60% of the patients showed improvement on their X-rays. This technique is recommended as an adjuvant to traditional tuberculosis therapy.

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.23

年代:1996

数据来源: MAL

摘要:

ABSTRACTVarious methods are used for treatment of hypersensitive dental necks. They all aim to seal exposed dentinal tubules, which are open toward the oral cavity and transmit stimuli to the sensitive nerve endings of the tooth pulp. The main sealing materials are fluoride preparations, strontium chloride, and hydroxyapatite. However, these materials must be applied periodically to achieve permanent freedom from pain. Since the introduction of laser technology into dentistry, efforts have been made to treat dentine hypersensitivity with the laser. Anin vitrostudy revealed that CO2laser irradiation results in almost complete closure of the dentinal tubules in the dental neck region. In the presentin vivostudy, the efficacy of laser treatment was examined in 72 patients with dentine hypersensitivity and 72 control patients over a period of 12 weeks. When success was defined as complete freedom from pain, the success rate in the laser group was 94.5%; when marked pain relief was included in the definition of treatment success, 98.6% of the patients were treated successfully. Treatment of the control group with conventional dental neck fluoridation resulted in no marked improvement. Laser Doppler measurements of pulpal blood flow immediately before and after treatment revealed no effects of laser irradiation on pulpal blood flow. Dentine samples were obtained from the dental necks 6 weeks after laser treatment and examined with atomic absorption spectroscopy (AAS). Tin was present in the samples, which suggests that the combined laser treatment and fluoridation result in permanent integration of fluoride in the dentine surface.

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.27

年代:1996

数据来源: MAL

摘要:

ABSTRACTDespite technical advances in the surgical treatment of infected wounds, this surgery remains a serious problem as it represents more than 27% of infection complications. In the majority of these operations, the wounds are left open and patients undergo long treatments of antibiotics. When the carbon dioxide laser technique was introduced in our country in 1984, it was tested using quantitative bacteriology: it was shown that when used on infected wounds, it reduced the bacterial population of these lesions to low levels with low tissue injury. At our center, between August 1984 and 1994, 539 patients with infected wounds were treated using a carbon dioxide laser. Out of 495 patients (91.84%) 1 patient was cured, 37 patients (6.86%) required more than one operation to be cured, and in 7 patients (1.30%) the treatment failed.

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.33

年代:1996

数据来源: MAL

摘要:

ABSTRACTThis study evaluated the clinical, radiographic, and histologic effects of the HGM PC Oralase argon laser on vital pulps of swine teeth. Pulpotomies were performedin vivoon 42 primary teeth from three young pigs and observed for 7 or 60 days. For each time period nine experimental teeth received an argon laser dose of 1 W, 2 sec (24.88 J/cm2), and nine experimental teeth received a dose of 2 W, 2 sec (49.74 J/cm2). Controls consisted of three teeth for each time period and did not receive exposure from the argon laser. There were no significant differences noted between the two energy densities with respect to clinical, radiographic, or histological parameters for either time period. All soft tissues remained normal and all teeth exhibited normal mobility at weekly assessments. Other than physiologic root resorption, there were no differences in pre- and postoperative radiographs in the 7 day sample; calcifications coinciding to dentinal bridges were visible radiographically in 8 of the 60 day samples. Reparative dentin formation was noted histologically in a total of 9 roots in the 7-day group and in 13 roots in the 60-day group. With the exception of teeth which had early restoration loss with resultant bacterial contamination, all other pulps appeared to retain their vitality and capability of normal pulpal healing. Use of the argon laser at the parameters described in this study did not appear to be detrimental to pulpal tissues.

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.37

年代:1996

数据来源: MAL

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.43

年代:1996

数据来源: MAL

ISSN:1044-5471    

DOI:10.1089/clm.1996.14.47

年代:1996

数据来源: MAL