ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

Glomus tumor of the skin and subcutis is an uncommon neoplasm in which the histologic features can be mimicked by other dermal lesions of diverse types. The cell of origin is thought by most to be the pericyte, which has some of the ultrastructural features of smooth muscle. We examined six glomus tumors with a panel of antibodies including the myogenic markers, muscle-specific actin (HHF-35), and desmin; all tumors were immunoreactive for muscle-specific actin, but only two expressed desmin. Half of these tumors expressed the endothelial determinant, factor VIII-related antigen. Pseudoangiomatous melanocytic nevi simulating glomus tumors were consistently immunoreactive for S-100 protein, which was not expressed by glomus tumors.

ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

This article describes a method of uniform gross-room sectioning of skin biopsy specimens, especially excisional biopsy specimens, to insure even thickness and maximum control of the tissue before paraffinization. This is accomplished by sequentially halving portions of the specimen after each cut as opposed to serially cutting the skin from one end to the other.

ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

The mutual relation and prognostic value of three quantitative variables were investigated in a retrospective series of 56 stage I cutaneous malignant melanomas. Unbiased stereological estimates of nuclear volume, nuclear &OV0456;vwere obtained along with measurements of melanoma thickness. The DNA index (DI) was determined by flow cytometry in adjacent sections from the same paraffin-embedded specimens. The correlation between tumor thickness and nuclear &OV0456;v,. was only moderate (r= .60). Euploid lesions had a smaller nuclear &OV0456;vthan aneuploid tumors (2p= .01), but with considerable overlap. No significant association between tumor thickness and DI could be demonstrated. Single-factor analysis showed prognostic value of nuclear &OV0456;vand tumor thickness (2p= .0007 and 2p= .03, respectively), whereas DI was without prognostic impact (2p= .54). When analyzing the three parameters in a Cox model, nuclear &OV0456;vwas the only independent, prognostically significant variable. Physical, three-dimensional nuclear volume is not solely a reflection of nuclear DNA content, and may represent a valuable, quantitative prognostic indicator in cutaneous malignant melanomas.

ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

This study was undertaken to assess the accuracy of his-tologic diagnosis of lymphomatoid papulosis (LyP). which may be confused with malignant lymphoma or other entities, It is essential that accurate diagnoses be made because LyP may be a marker for malignant lymphoma. All 15 examples of LyP reviewed in a dermato-pathology laboratory during a 14-year period and 180 his-tologic sections of tissue that could be confused with LyP were reviewed. Criteria for diagnosis of LyP were applied without benefit of clinical history, and revised diagnosis were made where indicated. Clinical follow-up information was obtained and original accuracy of diagnosis was assessed by comparing clinical courses with original his-tologic diagnoses. In cases of LyP in which numerous atypical lymphoid cells were present. 100% accuracy was noted. When fewer atypical lymphoid cells were present and inflammatory cell infiltrates were less dense, the diagnosis was less certain, Overall, a 64% correlation of clinical course and histologic diagnosis of LyP was noted. We conclude that the histologic diagnosis of LyP is generally reliable and accurate: however, in some cases a precise diagnosis cannot be made with certainty. Cases with fewer atypical lymphoid cells may fail to correlate well with the classic course of LyP and may represent a variant or histologic simulator.

ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

The pathology of 61 cases of disseminated superficial actinic porokeratosis was reviewed and the relative frequency of the histological features associated with the cornoid lamella and the pathology within and outside the porokeratotic rim were assessed. Papillary dermal lymphocytic infiltrate (97%). spinous layer vacuolar changes (90%), dyskeratotic cells in the epidermis (77%), and liquefaction degeneration of the basal layer (67%) were frequently seen under the cornoid lamella. Papillary lymphocytic infiltration was seen more frequently inside the porokeratotic ring in comparison to the outer skin. Lymphocyte marker studies in nine cases showed a predominance of activated T lymphocytes with positive LN3 and UCHL-1 staining. Together with the finding of a lichenoid reaction pattern, these results lend support to the hypothesis that actinic porokeratosis represents a migrating clone of abnormal keratinocytes with an associated im-munological host response.

ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

Human skin samples were obtained from the normal peripheral portion of specimens removed from persons with various cutaneous and systemic diseases. A portion of each specimen was embedded in paraffin and another part in water-soluble embedding medium, and some was fro-zen in liquid nitrogen for light microscopy and histochemistry. Some specimens were also investigated by electron microscopy. In 31 of 32 specimens, cells containing brown pigment were observed in the superficial dermis. Because both acid phosphatase and Masson-Fontana staining were positive and the 3,4-dihydroxyphenyl-alanine reaction negative, the cells were considered to be melanophages. Electron microscopic examination revealed that these cells contained melansome-laden phagosomes. Some fibroblastlike cells were also observed with intracellular single or multiple melanosomes. This study documents the occurrence of melanophages in the normal skin of Japanese subjects.

ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

The histopathologic criteria used in the diagnosis of dysplastic nevi have been a source of controversy, as has the clinical significance of these lesions. Several dermato-pathologists noted for their work on dysplastic nevi were asked to contribute responses to questions regarding the architectural and cytological criteria used to classify a melanocytic nevus as dysplastic. the terminology used to describe these lesions, and the role of dysplastic nevi as precursors of melanoma. Although no consensus has been reached regarding the cytologic features required for diagnosis of dysplastic nevi, there is substantial agreement regarding the architectural features of these lesions.

ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

A 75-year-old man with generalized subcutaneous fat necrosis was found to have an islet cell carcinoma of the pancreas. The histologic diagnosis of islet cell carcinoma was confirmed by electron microscopy. which showed characteristic intracytoplasmic granules. This is the second report of the association of islet cell carcinoma of the pancreas with generalized subcutaneous fat necrosis.

ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

Incontinentia pigmenti is a rare genodermatosis typically involving three stages: vesiculae, verrucous lesions, and hyperpigmentation. We clinically and pathologically documented a case from shortly after birth until the age of 17 years. Although the first two stages took a regular course, the third stage of the disease was characterized by hypopigmented streaks on the legs in addition to axillary hyperpigmentation. Similar hypopigmented areas were found in the patient's mother. Because pathological investigations of hypopigmented areas have been extremely rare, we performed light and electron microscopic studies and compared these with our findings in hyperpigmented regions. Light microscopy showed the hypopigmented streaks with slight epidermal atrophy and a reduced number of melanocytes and skin appendages. However, the main finding was round eosinophilic bodies in the upper dermis. Electron microscopic examination of these bodies demonstrated amorphous material that resembled colloid, suggesting degeneration of basal keratinocytes. Confirming previous reports. in hyperpigmented areas we found a reduction of pigment in those parts of the basal layer overlying melanophages located in the upper dermis.

ISSN:0193-1091    

出版商:OVID    

年代:1991

数据来源: OVID