ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

As cutaneous pilar leiomyomas have received little attention in the recent literature, 53 lesions from 45 patients were studied to analyze their clinicopathologic features. There was an equal distribution between both sexes; most patients were adults with a wide age distribution. Both multiple (29 lesions from 21 patients) and solitary tumors (18 patients) were included. Lesions on the extremity (29 tumors) were common in both groups, whereas truncal tumors (11) were confined largely to patients with multiple lesions. In six patients the number of lesions was not specified. The tumors were painful in 17 patients. Three patients had a positive family history of similar lesions. Histologic study revealed ill-defined bundles of well-differentiated smooth muscle cells in the reticular dermis in all cases, although nine lesions had a more nodular pattern. Overlying epidermal hyperplasia was noted in 29 cases (54.7%). Immunohistochemically there appeared to be an increased number of nerve fibers within and surrounding the tumors. Mitotic activity was observed in 15 lesions (28.3%), 13 of which had <1 mitosis per 10 high power fields (HPF); the remaining two lesions had 1-2 mitoses per 10 HPF. Follow-up was available in 10 of these mitotically active tumors and ranged from 9 months to 7 years. There was no recurrence in any of them. We have concluded tentatively that leiomyomas of arrector pili origin may exhibit a low mitotic activity of <1 per 10 HPF and that this does not adversely affect the prognosis for these patients.

ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Congo red staining of abdominal fat aspirates was used as a screening procedure for systemic amyloidosis in 100 consecutive patients with symptoms suggestive of systemic amyloidosis. Nine samples were positive for amyloid. To assess the reliability of the method, we reviewed the patients' clinical records and their other biopsy data. All nine patients with positive fat specimens had a clinical course suggestive of amyloidosis. Fat aspirates were positive in nine of 11 patients with documented systemic amyloidosis. The sensitivity of the abdominal fat aspiration-amyloid technique was 82%, its specificity was 100%, and the predictive value of a positive result was 100%. Sixteen patients underwent both cutaneous biopsy and abdominal fat aspiration, and the results of Congo red staining were concordant in all cases. Although this method requires training to avoid sampling difficulties, abdominal fat aspiration is a highly reliable screening procedure for the diagnosis of AL amyloidosis, AA amyloidosis, and familial amyloidotic neuropathy (FAP).

ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Thebcl-2gene family plays a significant role in the propagation of cell survival and tissue modeling. Bcl-2 was originally described in follicular lymphomas and is associated with the suppresion of cellular apoptosis. Evaluation for this protein has been performed for a variety of benign and malignant cutaneous tumors but not to any significant extent on inflammatory disorders. Therefore, we stained biopsy specimens from diseases with interface inflammation (lichen planus, acute graft-versus-host disease, and erythema multiforme) for Bcl-2. Epidermal expression of this protein was minimal for all three diseases; however, lymphocytes stained prominently in lichen planus. The data suggest that Bcl-2 is not prominently involved in the epidermal changes in these diseases. The role of other members of this oncogene family in interface dermatitis still needs to be elucidated.

ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Neutrophilic eccrine hidradenitis is a self-limited inflammatory dermatosis primarily induced by chemotherapeutic agents. We report the case of a 43-year-old patient treated with cytarabine, daunorubicin, and thioguanine for acute myelogenous leukemia who developed painful, red nodules in both axillae on the third day of chemotherapy. The lesions healed spontaneously without sequelae and reappeared once when chemotherapy was readministered.Histologic examination and immunohistochemical staining for carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), and S100 revealed necrosis of eccrine and apocrine glands. As a secondary event, neutrophils, histiocytes, and lymphocytes of T and B cell types were infiltrating the glandular coils. Electron microscopic examination confirmed the presence of severe cellular degeneration of the secretory epithelia and coiled sweat ducts. Ultrastructural features and absence of labeling with a nick-end labeling technique were consistent with a nonapoptotic mode of cell death.Our findings strongly suggest a cytotoxic effect of chemotherapeutic agents as accumulated in the secretory epithelia of sweat glands. Distal ducts and myoepithelial cells remained intact and may account for rapid regeneration of the glandular structures after discontinuation of chemotherapy. In view of the involvement of both eccrine and apocrine glands, we suggest the term neutrophilic hidradenitis, which is part of the spectrum of drug-associated sweat gland reactions.

ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Anthrax is a very rare disease in the United Kingdom. It is caused by the spore-forming bacteriumBacillus anthracis.Humans become infected when they come into contact with infected animals or their products. Cutaneous anthrax, the most common form of the disease, accounts for 95% of cases, and the disease usually developing on exposed sites. We present a patient who developed cutaneous disease after exposure to untreated leather. Owing to the initial clinical information, the biopsy specimen was misinterpreted as representing a severe acute insect bite reaction. The subsequent involvement by the Department of Microbiology established the correct diagnosis. Because today the disease is so rare in Europe and the United States, sporadic cases of anthrax are easily overlooked as the diagnosis often is not considered. Cutaneous anthrax should be considered in any patient with a painless ulcer with vesicles, edema, and a history of exposure to animals or animal products.

ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Verrucous carcinoma (VC) is a low-grade cutaneous squamous carcinoma which often presents on the foot where it is known as carcinoma cuniculatum. Three cases of VC on the buttock have previously been documented. We describe a highly unusual example of VC involving the buttock with extensive iliac bone erosion, and with the apparently unique feature of being totally subcutaneous.

ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Cutaneous cysts lined by ciliated epithelium are very rare, benign tumors predominantly occurring on the lower extremities of young women. We describe a ciliated cyst found in the perineum of a 60-year-old man. The location and histological features led us to attribute a primitive tailgut origin to this cyst, probably from the embryonic remnants of cloacal membrane. Only two previous examples of similar cysts were found in the literature.

ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1997

数据来源: OVID