ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID

摘要:

Two hundred specimens from lesions of lichen planus were studied by conventional light microscopy in order to assess their evolution, maturation, and regression. The most important finding was that Langerhans' cells appear in increased numbers in the epidermis very early in the disease, even preceding the appearance of lymphocytes there and then that the appearance of lymphocytes is followed by destruction of keratinocytes in the lower portion of the epidermis and by general epidermal hyperplasia, including hypergranulosis and hyperkeratosis. Wedge-shaped hypergranulosis develops around intraepidermal adnexal structures, namely, acrosyringia and acrotrichia. Finally, long-enduring inflammatory-cell infiltration in the papillary dermis was found to result in eventual fibrosis there, an evidence of resolution. With time the inflammatory-cell infiltrate disappears and the epidermis regains its normal configuration. Bullous lichen planus, hypertrophic lichen planus, atrophic lichen planus, and lichen planopilaris are variants of the same pathological process, modified by intensity and location of process.

ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID

摘要:

Four patterns of proliferation of eccrine sweat ducts were observed in examination of routine histologic sections of diseases of the skin. Sweat duct proliferation is a reactive process and must be differentiated from a benign adnexal neoplasm or an infiltrating malignant one.

ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID

摘要:

A 29-year-old woman with Wilson's disease developed dermolytic skin lesions 2 years after initiation of treatment with penicillamine. Eight years later, still on penicillamine therapy, striae appeared over both of her breasts. Biopsy of involved skin during the 10th year of treatment with penicillamine revealed characteristic lumpy-bumpy alterations of dermal elastic fibers which were not present in the first skin biopsy 8 years previously. Biopsy of a stria showed changes similar to those in the dermolytic skin lesions.Lumpy-bumpy elastic fibers are pathognomonic for penicillamine-induced elastosis. They are easily recognizable with examination by conventional microscopy. Their appearance may serve as a warning of potentially serious, widespread elastic tissue involvement. These abnormal elastic fibers are not only found in the skin, but also in the lungs.

ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1981

数据来源: OVID