ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

ABSTRACTIt has long been claimed that a specific histologic diagnosis of mycosis fungoides cannot be made in the “premycotic” or “eczematous” (patch) stage of the disease. Indeed, the histologic features of the premycotic lesions were constantly said to be those of “chronic non‐specific dermatitis.”We studied 46 biospy specimens of patch lesions from patients in whom mycosis fungoides was unequivocally established by clinical events (i.e., concurrence or later development of typical plaque and/or nodular lesions) and indubitable histologic findings. We divided patch lesions into early nonatrophic patches and late atrophic ones. The early patches are considered to be evolving lesions of mycosis fungoides, whereas late patches represent resolving plaques of the disease. On the basis of this study, we concluded that histologic diagnosis can be made with near certainty in patch lesions of the disease. We found that the critical feature for histologic diagnosis of early and late patch lesions of mycosis fungoides is the presence of an increased number of mononuclear cells distributed singly or in small collections within an epidermis devoid of spongiotic microvesiculation. Other important features are lacunae surrounding intraepidermal mononuclear cells which gives them the appearance of “haloed cells.” A sparse infiltrate of mononuclear cells is present around the blood vessels of the superficial, and sometimes the deep, vascular plexus. Atypical mononuclear cells are not necessary for the diagnosis of early patch lesions of mycosis fungoides, but they are found commonly in late patch lesions. Late atrophic patches show a thinned epidermis, loss of the usual configuration between rete ridges and dermal papillae, and coarse collagen throughout a thickened papillary dermis.

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

ABSTRACTCalcification in cutaneous blood vessels is an uncommon finding in biopsies submitted for dermatopathological examination. Of 14 biopsy specimens showing the phenomenon that was studied by us, the greater number was from women who had a combination of severe diabetes, hypertension, and atherosclerosis. Unusual clinical syndromes as the bases for the vascular calcification were hyperthyroidism in three patients and arteritis in two patients. Three patients died as a consequence of massive cutaneous infarction and sepsis, probably stemming from cutaneous vascular calcification. Vascular calcification in biopsy of skin may result from metabolic, inflammatory, or degenerative diseases of blood vessels.

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

ABSTRACTThe term keraton is proposed to denote that specific subpopulation of epidermal cells that matures to form epidermis and horny layer exclusive of other functional units within the epidermis such as melanocytes, acrosyringium, acrotrichium, Langerhans' cells, and nerves.

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

ABSTRACTA method which utilizes the enzyme chloroacetate esterase as a marker for cells of the neutrophil series, monocytes, and mast cells in tissue that has been fixed in formalin and embedded in paraffin is described in detail.

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

摘要:

ABSTRACTEvidence is presented that actinic granuloma is not a specific connective tissue disorder as it is thought to be by O'Brien. Granulomatous inflammation does not result simply from a response to elastotic fibers, but is a consequence of primary pathologic processes that are unrelated to damaged elastotic material. Twenty‐one of 30 lesions in our series that fulfill O'Brien's criteria of his concept of actinic granuloma were clinically and histologically examples of granuloma annulare. The other nine lesions were of other granulomatous diseases such as foreign‐body reaction and late secondary syphilis.

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID

ISSN:0193-1091    

出版商:OVID    

年代:1979

数据来源: OVID