摘要:

Abstract –Fluoride concentrations were measured in whole saliva samples collected from 16 subjects at different intervals up to 60 min after chewing of various supplementary F preparations: chewable E tablets (0.21 mg F), plain F tablets (0.25 mg F) or F‐containing chewing gum (0.25 mg F). Each of the F preparations was administered in a low dose (0.21–0.23 mg F) or in a high dose (0.42–0.50 mg F). Mean resting levels of fluoride in saliva ranged from 0.03 to 0.05 parts/106. Peak values averaging 15–25 parts F/106in the low‐dose group and 25–40 parts F/106in the high‐dose group were recorded within 5 min after intake. After 30 min, the salivary fluoride concentrations in both groups had decreased to levels below 1 part/106and approached resting levels 60 min after intake. The availability of fluoride in saliva, as estimated from AUC values (areas under curves, relating fluoride concentrations to the time from 0 to 60 min), was similar with each of the preparations applied in the low dose. When used in the high dose, the chewing gum and also the plain tablets provided significantly more fluoride in saliva than the chewable tablets. The data may suggest that unflavored plain F tablets are equally suitable as a vehicle for fluoride aiming at a topical cariostatic effect as specially designed chawable tablets

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1979.tb01934.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract –The role of neutrophilic granulocytes in the loss of gingival collagen has been studied by inducing experimental neutropenia during initial gingivitis in beagle dogs. Neutropenia was induced for 4 d in three animals with normal gingiva by repeated injections of rabbit anti‐neutrophil serum. During neutropenia microbial plaque was allowed to form on the teeth. Samples of junctional (crevicular) leukocytes and gingival fluid were taken on days 0 and 4. Block biopsies of buccal gingiva were obtained on day 4. Stained semi‐ and ultrathin sections were used for histometric and serologic tissue analysis. Gingival fluid flow increased from day 0 to day 4 in all dogs while junctional leukocytes increased in one dog only. Subgingival plaque had formed in most biopsies, and in the junctional epithelium very few neutrophilic granulocytes were present. In the coronal connective tissue subjacent to the junctional epithelium lymphoid cells, structurally abnormal neutrophilic granulocytes and monocytes/macrophages were diffusely scattered. The gingival collagen appeared mainly displaced by the inflammatory cells rather than dissolved. The data suggest that neutrophilic granulocytes may contribute to the loss of gingival collagen during initial gingivitis in dogs. The neutrophils also seem to be of importance for the limitation of subgingival plaque growth along the tooth su

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1979.tb01935.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract –The supragingival and subgingival dental plaque flora ofMacaca arctoidesandMacaca fascicularismonkeys were examined using mylar strip impressions, direct smears, and cuiture techniques. In smears, samples generally contained 40–50% cocci, 20–30% rods, 8–20% fusiform bacteria, and 4–5% each of filaments, vibrios and spirochetes. Differences in the ratios of the various bacterial groups related to age and sex were found. Several monkey bacterial species were similar to those in human dental plaque. The present results indicate that theMacacafemale monkey can be a suitable animal model for the experimental studies of dental

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1979.tb01936.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract –Responses of 241 pulpal and 219 non‐pulpal nerve fibers to monopolar electrical stimulation were studied in 12 anesthetized cats. Stimulation was carried out with a clinically used pulp tester (Bofors PT‐1®) to the intact crown of mandibular canine tooth and to the surrounding soft tissues not further than 1.5 cm from the tooth. Action potentials from nerve preparations containing either a single or a few functional fibers were recorded. The minimum current strength needed to excite the axon (“threshold current”) was determined. The purpose of the study was to investigate how specifically monopolar electrical stimulation of the tooth crown excites the nerves of the dental pulp and to what extent fibers of surrounding tissue are affected. The mean threshold of excitation of the pulpal nerve fibers was 28.3 μA ± 1.4 s.e.m. Of 219 non‐pulpal fibers sensitive to mechanical stimulation of the tooth and the surrounding area, only 10 fibers of periodontal origin were caused to discharge due to electrical stimulation applied to the tooth crown. Their mean threshold was 96.0 μA± 5.2 s.e.m. When the receptive fields of 50 mechanoreceptor units in soft tissue were stimulated electrically, only nine responded to current values less than 125 μA. It seems that pulp nerve fibers respond to very much lower current intensities than non‐pulpal fibers, when monopolar electrical stimulation is applied to the tooth crown. The risk of activation of non‐pulpal nerves in pulp tests seems to be minimal supposing that reasonable cur

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1979.tb01937.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract –Vincristine was administered to 60 rats in four groups in doses of 0,1, 0,3, 0,5 and 0.7mg/kg. Histomorphologic investigation of the dentin and odontoblasts in the maxillary incisors after 1, 2 and 3 weeks revealed a moderate to severe disturbance of dentin production in some parts of the incisors. In some of the affected areas the effect seemed to be reversible in that normal‐appearing dentin was found pulpal to the dentinal derangements after 2 and 3 weeks. The distribution and severity of the lesions were similar to those previously observed 3 days after injection of the same doses of vincrist

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1979.tb01938.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract –A hitherto undescribed clinical and histologic entity occurring in the palate of 13 denture‐wearing patients is described. Clinically it is characterized by the presence of small yellowish areas in the hard palate, which on pressure yield a whitish creamy material through multiple openings. The surrounding mucosa may exhibit various degrees of erythema. The histologic changes are characterized by the presence of intramucosal fistulae lined with unkeratinized squamous epithelium. The content of the fistulae, which corresponds to the creamy material expelled, consists of desquamated epithelial cells. These changes have mostly been nodced in elderly females, all wearing maxillary dentures for many years. This entiPf is considered a type of demure stomatitis characterized by intramucosal proliferation of epithelium, possibly because of long‐standing chronic irritation from dentures. The origin of the intramucosal fistulae is unknown. The fistulae are believed to originate either from the ductus of the minor salivary glands or from the surface epithelium of the p

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1979.tb01939.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract –Eight patients undergoing antidepressant therapy with nortriptyline for 1–4 years were investigated. The period of the investigation was 7 weeks and included a 2‐week placebo period, blind for the patients. Total saliva secretion measurement, the nortriptyline plasma level, and signs and symptoms of depression and side effects were obtained once a week during the study. The results of the investigation were: (1) long‐term treatment with nortriptyline is followed by hyposecretion or xerostomia, (2) the reduction of the secretion is reversible, (3) re‐establishment of treatment with dosage leading to the same serum level of nortriptyline is immediately followed by a drop in saliva secretion, and (4) the changes in salivary secretion are useful as an indicator of side effects. The practical importance of the investigation is

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1979.tb01940.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract –Both bone‐forming and bone‐destructing cells may appear in different forms. This conclusion has been drawn as a result of compared observations from histomorphologic, histochemical and vital staining studies. The bone‐forming cells may be cuboidal and situated in one or more rows along the bone surfaces, or may be flat. The type of cell reflects the rate of bone formation. The bone‐resorbing cells may be big multi‐nucleated cells or small mononucleated cells. The latter cell type is well‐known from the literature although not referred to in textbooks of histology. Flat bone‐forming cells and small mononucleated bone‐resorbing cells resemble each other in the light microscope. Studies of bone growth with the aid of histomorphologic descriptions of cell types have to take this fact into account. Otherwise, erroneous conclusions ma

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1979.tb01941.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract –The present study has shown that it is possible by utilizing the principle of diffusion to precipitate on stone dies an adequate resin spacer of uniform and desirable thickness. Details and variables of the technique are described. The precipitation technique is simple and requires a minimum of time and equipment. This spacer technique opens up gateways for a new and improved casting technique cleared of most of the variables affecting the precision of the methods employed up till now. A new gypsum bonded investment for the new casting technique is being develope

ISSN:0909-8836    

DOI:10.1111/j.1600-0722.1979.tb01942.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY