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1. |
Response: Neural Sympathetic Activity in Essential Hypertension |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 3-4
Markus Schlaich,
Murray Esler,
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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2. |
Ray W. Gifford, Jr, MD (1923–2004) |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 109-110
Edward Frohlich,
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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3. |
Remembering Dr Ray W. Gifford, Jr (1923–2004) |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 111-111
William Manger,
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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4. |
Nitric Oxide and the Regulation of Large Artery StiffnessFrom Physiology to Pharmacology |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 112-116
Ian Wilkinson,
Stanley Franklin,
John Cockcroft,
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PDF (37KB)
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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5. |
Mediastinal Fat, Insulin Resistance, and Hypertension |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 117-118
Arya Sharma,
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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6. |
Shear Stress and Flow-Mediated Dilation |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 119-120
Michael O’Rourke,
Wilmer Nichols,
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PDF (158KB)
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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7. |
Peripheral Pulse Pressure, Large Arteries, and Microvessels |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 121-122
Michel Safar,
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PDF (15KB)
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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8. |
Hypertension Associated With Therapies to Treat Arthritis and Pain |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 123-124
William White,
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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9. |
Trial of Preventing Hypertension (TROPHY)Design and 2-Year Progress Report |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 125-126
Norman Kaplan,
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ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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10. |
Visceral Fat in HypertensionInfluence on Insulin Resistance and β-Cell Function |
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Hypertension,
Volume 44,
Issue 2,
2004,
Page 127-133
Anna Sironi,
Amalia Gastaldelli,
Andrea Mari,
Demetrio Ciociaro,
Vincenzo Postano,
Emma Buzzigoli,
Sergio Ghione,
Stefano Turchi,
Massimo Lombardi,
Ele Ferrannini,
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摘要:
Preferential visceral adipose tissue (VAT) deposition has been associated with the presence of insulin resistance in obese and diabetic subjects. The independent association of VAT accumulation with hypertension and its impact on insulin sensitivity and β-cell function have not been assessed. We measured VAT and subcutaneous fat depots by multiscan MRI in 13 nondiabetic men with newly detected, untreated essential hypertension (blood pressure=151±2/94±2 mm Hg, age=47±2 years, body mass index [BMI]=28.4±0.7 kg · m−2) and 26 age-matched and BMI-matched normotensive men (blood pressure=123±1/69±2 mm Hg). Insulin secretion was measured by deconvolution of C-peptide data obtained during an oral glucose tolerance test, and dynamic indices of β-cell function were calculated by mathematical modeling. For a similar fat mass in the scanned abdominal region (4.8±0.3 versus 3.9±0.3 kg, hypertensive subjects versus controls,P=0.06), hypertensive subjects had 60% more VAT than controls (1.6±0.2 versus 1.0±0.1 kg,P=0.003). Intrathoracic fat also was expanded in patients versus controls (45±5 versus 28±3 cm2,P=0.005). Insulin sensitivity was reduced (10.7±0.7 versus 12.9±0.4 mL · min−1· kgffm−1,P=0.006), and total insulin output was proportionally increased (64 [21] versus 45 [24] nmol · m−2· h, median [interquartile range],P=0.01), but dynamic indices of β-cell function (glucose sensitivity, rate sensitivity, and potentiation) were similar in the 2 groups. Abdominal VAT, insulin resistance, and blood pressure were quantitatively interrelated (ρ’s of 0.39 to 0.47,P<0.02 or less). In newly found, untreated men with essential hypertension, fat is preferentially accumulated intraabdominally and intrathoracically. Such visceral adiposity is quantitatively related to both height of blood pressure and severity of insulin resistance, but has no impact on the dynamics of β-cell function.
ISSN:0194-911X
出版商:OVID
年代:2004
数据来源: OVID
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