摘要:

ABSTRACTOf the 44 patients of urticaria in children in 52.3 percent, the etiologic agents were defined with food as the major cause. The clinical features were characterized by itching, erythema, wheals and oedema of different configuration. The urticaria lesions were commonly seen on the extremities and the trunk. Largely the patients applied for treatment in the course of a week. Majority of the patients were in the age group of 5–9 years. The acute urticaria was most frequent, while the other variants were rare. The laboratory investigations were largely equivocal. The parasitic infestations in particular as etiologic factors were inconclusiv

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00933.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTSix cases diagnosed as Gianotti‐Crosti syndrome were divided into 2 groups, a group with liver dysfunction and a group with normal liver function, and the other signs and symptoms of the 2 groups were compared with special attention to differences in the cutaneous findings. The eruption in the group with liver dysfunction corresponds to that of Gianotti disease and in the group with normal liver function to that of Gianotti syndrome, which led to the conclusion that the two should be differentiated. The important points of differentiation are summarized as follows:In Gianotti disease there is acute hepatitis and the eruption is monomorphous with multiple disseminated 3–4 mm in diameter, copper red, flat‐topped papules. Gianotti syndrome is without hepatitis, and the eruption consists of irregularly distributed 2–4 mm in diameter, faintly erythematous, hemispherical papules, but is frequently polymorphous, with intermingled vesicle‐like, hemorrhagic, and molluscum contagiosum‐li

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00934.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTA 21‐year‐old man with angiokeratoma corporis circumscriptum neviforme (ACCN) involving his left buttock, thigh, leg, and foot was treated by resection of the lesions followed by skingrafts. The lesions had gradually spread and proliferated for 10 years following previous surgical therapy in our department.Histopathologic examination of the lesions revealed a marked hyperkeratosis of the epidermis; the upper dermis showed capillary dilatation and proliferation, and a distinct proliferation of immature endothelial cells of capillaries was noted in the middle and deep dermis.Additionally, 34 cases of ACCN reported in Japan are reviewed. Possible etiologic factors considered are a lack of oxygen and nutrition in the tissue due to a disturbance of blood circulation, and repeated trauma to the lesi

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00935.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTThe potential to cause a primary irritant reaction is usually evaluated by clinically recognizable dermatitis at the site of patch testing. Such evaluation is difficult in the case of substances with low irritancy potential which sometimes fail to cause grossly visible signs of dermatitis. In those cases a higher concentration of the test substance may be used in order to produce a visible reaction, but such concentrations may lead to unnecessary irritation and are of little value in determining the safety of the substance in concentrations of practical use.The microscopic appearance of normal human skin observed on a skin replica made by Susuki's Universal Microscopic Printing (SUMP method) has been reported previously by the author (9). In the present study, patch test reactions which fail to produce grossly visible inflammation were observed for microscopic changes by the SUMP method. The patches were applied to the upper arms of normal humans for 24 hours and then the test sites were observed for gross inflammation and microscopically by the SUMP method. Numerical scores were assigned to grade each microscopic change produced in the skin surface and total scores were used to grade the irritancy reaction produced. These scores were compared to results using Zontes TA‐430, which has been used for over 10 years as a softening agent of fibers and was used in this study as a control chemical substance with no irritancy. The results revealed microscopic changes provoked by irritants too weak to produce gross inflammation. A criteria for grading cutaneous primary irritant reactions by microscopic findings was determine

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00936.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTFour patients with perioral dermatitis are reported. They are the first cases reported in Japan. All had had topical applications of fluorinated corticosteroids, and application of a non‐fluorinated hydrocortisone ointment on one case was followed by an exacerbation. Oral administration of tetracycline was accompanied by improvement in all four case

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00937.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTEpidemiological, clinical, and mycological studies based on a total of fifty‐eight cases of human ringworm caused byTrichophyton verrucosumwere made. They consisted of thirty‐nine epidemically occurring cases in the Tono area of Iwate prefecture in 1962 and nineteen cases occurring sporadically in Miyagi and Yamagata prefectures from 1970 through 1973. The results are summarized as follows: 1) The majority of the patients were farm workers or their family members, who had opportunity for direct contact with infected cattle. 2) The infection was most frequent during the winter months. 3) Familial occurrence was noted in twenty‐six members of eleven families. 4) The most commonly affected sites were the exposed areas of the body, particularly the forearm of an adult and the face of a child. 5) The clinical features of the lesions were classified into the following six types: agminate folliculitis, tinea circinata, kerion celsi, sycosis trichophytica, granuloma trichophyticum Majocchi, and a hyperkeratotic form of tinea manum which may be previously unreported. 6) In general, lesions showed a marked inflammation with intense erythema, edema, and pustule formation, and without central clearing. 7) The causative organism easily invades the hair follicle, so that a deep‐seated lesion may not be uncommon. 8) On comparative studies, the brain heart infusion agar (Difco) containing dextrose, peptone, thiamine HCl and antibiotics was found to be adequate for the isolation and the identification ofTrichophyton verrucosum. 9) The fungus grew more easily at 37 °C than at room temperature (25 °C), and growth was inhibited by the addition of actidione. 10) The lesions of the agminate folliculitis type and of the hairy parts should be treated orally with griseofulvin because of a possible aggravation due to topical medication.Outside of the Tohoku district of Japan a total of thirty‐eight cases have been observed in Hokkaido from 1967 to 1972 and four cases were seen in southwestern Japan in two r

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00938.x

年代:1975

数据来源: WILEY

摘要:

ABSTRACTAntibody against human lysozyme was purified from sera of immunized rabbits using the immuno‐absorption technique.After conjugation of the purified antibody against human lysozyme with fluorescein isothiocyanate (FITC), immunofluorescent studies were carried out on both normal human skin and peripheral blood cells. Specific immunofluorescence appeared in the cytoplasm of epidermal cells and was much stronger in the upper cell layer than in the basal cell layer. Only slight fluorescence appeared in the horny layer. In the dermis, linear fluorescence was found along collagen fibers. In the immunocytological examination of peripheral blood cells, lysozyme was found in the cytoplasm of the polymorphonuclear leucocytes (PMN's

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00939.x

年代:1975

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1975.tb00940.x

年代:1975

数据来源: WILEY