摘要:

AbstractSphingolipids, a major constituent of intercellular lipids, are an important determinant for both water‐holding and permeability barrier function in the stratum corneum. To assess the pathogenic role of sphingolipids in the stratum corneum of dry skin disorders such as xerosis and asteatotic eczema in leg skin, ceramides were quantified by thin layer chromatography after n‐hexane/ethanol extraction of resin‐stripped stratum corneum and evaluated as μg/mg stratum corneum. In healthy leg skin (n=49), there was age‐related decline in the total ceramide, whereas xerosis (n=25) and asteatotic eczema (n=16) suffering significantly reduced water‐holding properties, exhibited no definite decrease, rather slight increase in ceramide quantity with the same composition of each individual ceramide as compared to healthy age‐matched controls. These data indicate that the seemingly elevated level of ceramide is an artificial effect due to inflammatory processes which result from susceptibility to dryness. Analysis of sebum‐derived lipids present in the stratum corneum revealed that there was a significant decline in free fatty acids in xerosis and asteatotic eczema as compared to age‐matched healthy controls, and a similar decline in triglycerides in the above three groups when compared to younger controls. Although the observed decrease in the stratum corneum lipids may well explain the high incidence of winter dry skin in older people, the progression toward asteatotic eczema can not be accompanied solely by a decrease in ceramide quantity, suggesting that the evolution of xerotic skin is associated with other moisturizing factors and/or envir

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03820.x

年代:1993

数据来源: WILEY

摘要:

AbstractHeterologous elastin particles were injected into the deep dermis or below the panniculus carnosus of hairless mice. A granulomatous tissue reaction with concomitant giant cell formation occurred around the implanted elastin in the early stages and, subsequently, calcium deposition with disappearance of the histiocytes and giant cells occurred in the later stages. Ultrastructural study revealed that some elastin particles were engulfed by the giant cells; others underwent calcification but remained intact.The heterologous collagen used as a control also induced a granulomatous tissue reaction, but did not undergo calcification and gradually disappeared.These results suggest that the heterologous elastin and collagen particles exhibit different susceptibilities to digestion. However, it is not clear why the heterologous elastin underwent calcification.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03821.x

年代:1993

数据来源: WILEY

摘要:

AbstractSince phenolic glycolipid‐I (PGL‐I) is an unequivocal marker forMycobacterium leprae, this antigen has been a good candidate for the serodiagnosis and monitoring of the effectiveness of leprosy chemotherapy. The present study, a continuation of an earlier report, was undertaken to estimate PGL‐I antibody titers in 40 leprosy patients 3 and 6 months after starting MDT. All the leprosy groups showed significant declines in anti PGL‐I reactivity after 6 months. There was a good correlation between bacteriological indices (BI) and anti PGL‐I antibody levels. Thus, PGL‐I based serology may be useful in monitoring the response to multid

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03822.x

年代:1993

数据来源: WILEY

摘要:

AbstractWith the objective of comprehending abnormal metabolisms of the essential metals of zinc (Zn) and copper (Cu) in three groups of skin diseases, skin cancer, inflammatory diseases, and non‐inflammatory disease, we measured serum levels of Zn and Cu in 151 cases of various cutaneous manifestations and estimated the significance of the ratios between the two metals (Cu/Zn). The serum level of Zn was significantly decreased in cases of bullous pemphigoid, decubitus ulcer, and alopecia areata. The serum level of Cu was elevated in cases of psoriasis, decubitus ulcer, and skin cancer. We observed no elevation of serum Zn level or abnormally depressed serum Cu level. The Cu/Zn ratio showed significantly different values among these three groups of the diseases, suggesting the utility of measuring Cu/Zn ratios for differential diagnosis over that of determining the serum level of Zn or Cu alone. It was also demonstrated that, in each skin disease, the Cu/Zn ratio clearly reflects the severity of the progres

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03823.x

年代:1993

数据来源: WILEY

摘要:

Abstractγ‐Glutamyl transpeptidase (GGT) was extracted from squamous cell carcinoma tissues of human skin (SCC) by Triton X‐100 and bromelain treatment, and some of its biochemical properties were compared with those of GGT extracted from eccrine gland‐rich tissue and normal kidney. GGT activity significantly increased in SCC, but there was no definitive differences in enzymological properties between GGT of SCC and normal tissue enzyme. However, GGT of SCC was distinguishable from those of normal tissues by isoelectric point, electrophoretic mobility, and sensitivity to neuraminidase treatment. These results indicate that GGT of SCC has some variant properties which may be related to skin carcinog

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03824.x

年代:1993

数据来源: WILEY

摘要:

AbstractDermatomyositis, recognized as an autoimmune disorder, occurs not only in adults but also in children. In this study, we evaluated lymphocyte subpopulations in the peripheral blood of 24 adult dermatomyositis and 14 juvenile dermatomyositis patients and in 17 healthy adults and 9 healthy children by flow cytometry using monoclonal antibodies. When compared with healthy adults and adult patients with inactive dermatomyositis, the adult patients with active disease had significantly lower percentages of CD3+and CD8+cells and a significantly higher percentage of CD20+cells. In contrast, juvenile dermatomyositis patients had lymphocyte subpopulations not significantly different from those of healthy children; the activity/inactivity of disease did not make any difference. These results support our hypothesis that adult and juvenile dermatomyositis may be diseases of entirely different scope.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03825.x

年代:1993

数据来源: WILEY

摘要:

AbstractLangerhans cells are dendritic cells of the epidermis originating from bone marrow precursors which may exceptionally undergo mitosis within the skin. We report herein an electron‐microscopic observation of a dividing LC within a seemingly hyperproliferative human epidermis. This observation further underlines the self‐reproducing capacity of LCin situand suggests that LC may respond to the same mitogenic stimuli as keratinocy

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03826.x

年代:1993

数据来源: WILEY

摘要:

AbstractA case of cutaneous B‐cell lymphoma successfully treated by MACOP‐B therapy is described. The patient was a 43‐year‐old man with reddish tumors measuring 3 to 7 cm in diameter on the right cheek and the post‐auricles. Histopathologically, massive infiltrations of medium‐sized atypical lymphoid cells were found in the reticular dermis and subcutis. A clear zone beneath the epidermis was also detected. The atypical lymphoid cells were positive for CD19, CD20, CD22 and HLA‐DR but negative for CD3, CD4, CD5, CD10, CD43, CD45RO and CDw75. The patient was treated successfully with the MACOP‐B protocol from March of 1990 to May of 1990. Since April of 1990, he has been

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03827.x

年代:1993

数据来源: WILEY

摘要:

AbstractA 50‐year‐old Japanese female with progressive systemic sclerosis (PSS, CREST syndrome) is reported. During treatment for PSS, she was diagnosed by clinical and laboratory findings as having sarcoidosis, which was confirmed by histological examination of the skin and lymph nodes in July of 1991. She complained of back pain in August of 1991. Reflux esophagitis and Barrett's esophagus, found by endoscopy, progressed into a well‐differentiated tubular adenocarcinoma. This is a very rare case of PSS associated with sarcoidosis and esophageal adenocarcinoma developing from Barrett's esop

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03828.x

年代:1993

数据来源: WILEY

摘要:

AbstractThis paper presents a case of sinus histiocytosis with massive lymphadenopathy (SHML) presenting as erythroderma in an XYY‐male aged 27. The patient had little or no scalp, axillary, or pubic hair. Histologically, lymph nodes indicated dilatation of the sinuses with proliferation of benign‐appearing histiocytes possessing abundant clear cytoplasm, admixed with giant cells and pericapsular fibrosis. Infiltrating histiocytes in the lymph nodes were OKM‐1 (CD11b) positive, which is characteristic of monocyte‐granulocyte lineages. In the present case, the abnormal presence of erythroderma, hair loss, SHML, and a chromosomal abnormality, XYY, were thought to be incidental f

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1993.tb03829.x

年代:1993

数据来源: WILEY