摘要:

ABSTRACTUsing electron microscopic methods, we observed the fine structure of fungal elements occurring in a facial granulomatous infection caused byTrichosporon cutaneum.Two types of fungal elements were recognized: (1) fungal elements attached to phagocytes or just ingested into phagocytes and (2) fungal elements located within the phagocytes in the process of being digested.All the fungal elements observed had been denatured to varying degrees. In these denatured fungal elements, the intracellular organelles had disappeared. Fibrillar structures derived from the cell wall were recognized.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02596.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTThe lipids from the contents of an epidermal cyst were analysed quantitatively. Cholesteryl ester, triglyceride, free fatty acids, cholesterol, ceramide and some phospholipids were determined.Fatty acid components of some lipids (cholesteryl ester, triglyceride, free fatty acids and ceramide) were also analysed. The fatty acid component of ceramide included a high proportion of long chain fatty acids. The fatty acid portion of cholesteryl ester contained a relatively larger proportion of odd numbered, straight chained monoenes (C17:1etc), which were also found in ceramide at a lower concentration. The odd numbered monoene, C17:1in which the double bond is located atΔ9, was considered to be an intrinsic component of epidermal cyst contents.The lipid pattern and fatty acid compositions of the lipids of the contents from an epidermal cyst were similar to those of the human epidermal corneum

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02597.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTGuinea pigs primed for delayed type hypersensitivity (DH) to antibiotics such as penicillin G (PCG), carbenicillin (CBPC), sulbenicillin (SBPC), ampicillin (ABPC), cephalexin (CEX), cephalothin (CET) and cephazolin (CEZ) by immunization in mycobacterial adjuvant developed a generalized rash (GR) and flare‐up of previous test sites when challenged peritoneally with high doses of specific antigen. The GR was delayed in time, and histologically characterized by dilated and compacted small vessels and leucocytic infiltrations into the upper dermis. Animals immunized with CEX or CET developed a strong GR despite the absence of detectable antibodies.Hapten‐carrier specificity and cross‐reactivity in the GR system were essentially the same as those observed in skin testing of DH, but differed from those in the hemagglutination system.Accordingly, the GR shares many of the properties of DH skin test reactions: time course, histology, development despite an absence of detectable antibodies, carrier specificity, cross‐reactivity. This experimentally induced rash may be a useful model for delayed type, generalized, exanthematic drug eruptions

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02598.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTThree out of fifteen cases of disseminated malignant melanoma with complete or partial responses to our combined chemoimmunotherapy, DTIC, ACNU, VCR and OK432, are reported. Case 1 responded completely with disappearance of skin and brain lesions. Case 2 responded partially to a lung metastasis. Case 3 responded totally with the complete disappearance of lung and brain metastatic lesions. None of these cases suffered any significant side effects during the trial.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02599.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTSerial serum samples from sixteen patients with pemphigus were assayed for Clq binding activity (ClqBA) using a modified solid phase Clq binding assay. The modification included use of horseradish peroxidase instead of125I or131I. ClqBA was detected in six of the sixteen patients. Sequential samples from those positive patients demonstrated a decrease in ClqBA in response to steroid therapy.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02600.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTA fatal case of postirradiation malignant fibrous histiocytoma was reported, with a review of postirradiation sarcoma in the Japanese literature.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02601.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTThe penetration of hydrocortisone, hydrocortisone 17‐butyrate 21‐propionate, betamethasone, betamethasone 17‐valerate, and clobetasol 17‐propionate through separated human epidermis was compared. The amount of each topical corticosteroid which was released on the skin and penetrated to saline was greater in ethanol solution than propylene glycol solution. The addition of water to the ethanol increased the release of some corticosteroids. The lipid solubility of each corticosteroid correlated well with skin penetration; however, the polarity of each corticosteroid was inversely proportional to skin penetration. The results of the blanching phenomenon caused by the application of these corticosteroids and of their skin penetration suggested to us that the local pharmacological activity of each topical corticosteroid, rather than their skin penetration, related well to their clinical effect

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02602.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTStellate ganglion block and epidural block have been found to be beneficial for the treatment of herpes zoster, especially for the prevention of postherpetic neuralgia.

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02603.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTIntraepidermal free nerve endings were studied in spotted (black and white) guinea pigs. Specimens were obtained from black, gray, and white areas. Twenty blocks were made from each area and sections were examined by electron microscopy. Intraepidermal free nerve endings were found in the interfollicular epidermis of all three areas. The distribution density for the black areas was about twice that for the white areas. The frequency in the gray areas was intermediate between that for the black areas and that for the white areas. Intraepidermal free nerve endings contacted the melanocytes directly in the interspaces between the basal lamina of the epidermis and the cytomembrane of the melanocyte or the dendrite of the melanocyte in the intercellular spaces between basal keratinocytes. In most cases, their axons were ensheathed by Schwann cells. In some cases, a part of the axon expanded like a balloon about 200–300 nm in diameter. The ballooning structure contained several vacuoles about 40–60 nm in diameter. These vacuoles seemed to have been secreted into the extracellular spaces. In such cases, an accumulation of dense materials was observed along the opposed membrane of the vacuole and the cytomembrane of the melanocyte. In other cases, the cytomembranes of axons and those of melanocytes seemed to form synapse‐like struc

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02604.x

年代:1982

数据来源: WILEY

摘要:

ABSTRACTThe roles of tyrosinase andγ‐glutamyl transpeptidase (γ‐GTP) in 5‐S‐cysteinyldopa (5‐S‐CD) genesis in melanotic and amelanotic melanoma cells has been investigatedin vitroandin vivo. Complete inhibition of tyrosinase by 10–3M diethyl dithiocarbamate has been found to partially inhibit dopa‐cysteine dependent 5‐S‐CD genesis by cultured melanoma cells. On the other hand iodoacetamide, an inhibitor ofγ‐GTP, has been found to completely inhibit dopa‐glutathione dependent 5‐S‐CD genesis by these cells. Melanotic melanoma has been found to be rich in tyrosinase andγ‐GTP activity. In contrast, the amelanotic melanoma studied here was found to lack tyrosinase activity and to have very littleγ‐GTP activity. The sub‐cellular distribution of these enzymes in melanotic melanoma cells has revealed that while the melanosome‐rich fraction is high in tyrosinase activity, it contains no substantialγ‐GTP activity. These findings indicate that 5‐S‐CD can form non‐enzymicallyin vitrofrom dopa and cysteine. Further, it also provides evidence thatγ‐GTP is the enzyme that conve

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1982.tb02605.x

年代:1982

数据来源: WILEY