摘要:

ABSTRACTThe fine structure ofFonsecaea pedrosoiwas studied by freeze‐etching techniques. The structure of the cell wall as seen in Trichophyton groups was not observed. The invaginations were clearly shown in the plasma membrane. Three‐dimensional views of the fine structure were presen

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01003.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTA 46‐year‐old housewife was treated orally with 5‐fluorocytosine (5‐FC). She was almost cured at 15 weeks after the administration. Under histological and electron microscopical examination, spores in the lesions were observed to be markedly decreased in number, and all of them had suffered a change of shape or had been destroyed. At the end of 33 weeks, however, the patient had a complete

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01004.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTExfoliatin, an exotoxin produced by phage group 2 staphylococci, was separated and was analyzed. The toxin was separated in a single peak by Sephadex G‐100 gel filtration and subsequent DEAE Sephadex chromatography. By acrylamide gel disc electrophoresis this single peak was found to contain 2 components both of which posessed exfoliative activity and the same antigenic properties. Their molecular weight, however, differed; the major component had a molecular weight of 30,000 and the minor component had 27,000. The toxin was stable when heated at 60°C for 40 minutes, and labile at 100°C for 20 minutes.The toxin was immunogenic to mice and produced antibody Which could be transmitted to neonatal mice to neutralize exfoliative activity of the toxin. Innoculation of the bacteria caused the production of antibodies against both exfoliatin and α‐hemolysin in mice. The antibodies were also transmitted to neonatal mice to neutralize the exfoliative activity of exfo

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01005.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTA patient, having been treated by total cystectomy and Bricker's conduit operation for prostatic duct carcinoma with intraepithelial extension into the prostatic urethra and bladder, developed an annular, psoriasiform eruption around the external orifice of the urethra two and one‐half years later. A biopsy of this lesion showed pagetoid changes of the epidermis. Microscopic examination of the surgical specimen, consisting of the glans penis and corpus spongiosum, demonstrated intraepithelial‐tumor permeation into the glans penis, penile urethra, and periurethral glands (Littre). It seems reasonable to conclude that this is an unusual case of Paget's disease of the glans penis which probably originated from a prostatic duct carcin

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01006.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe relationship between the titer of pemphigus antibody and the clinical course of the disease was investigated in 15 patients with various types of pemphigus.Although antibody titers generally ran parallel to fluctuations of the clinical course, the elevation of antibody titer appeared to follow the re‐appearance or exacerbation of the lesions on 10 occasions in 6 patients, while it appeared to precede the latter only on 2 occasions in 2 patients. In addition, the disappearance of the antibody was considerably delayed after disappearance of skin lesions in 2 cases. These findings suggest that the pemphigus antibody is the result of skin damage, rather than the cause of pemphigus itsel

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01007.x

年代:1977

数据来源: WILEY

摘要:

ABSTRACTIn order to elucidate the immunological mechanism in the pathogenesis of pityriasis rosea, immunofluorescent studies were performed on sera obtained from forty patients with this disease. Antibodies against the cytoplasm of normal human epidermal cells were demonstrated in the sera of all patients. The antibody titer showed a tendency to increase within 3 weeks after onset of secondary eruptions and then to decrease gradually until the period of recovery. The immunoglobulin class was determined to be IgM. Furthermore, by the direct immunofluorescent technique, deposits of IgM in the epidermal cells of skin lesions were demonstrated in 3 of 6 herald lesions and in 1 of 4 secondary eruptions.It is suggested that anti‐cytoplasmic antibodies produced by some unknown cause may induce the development of secondary eruptions of this diseas

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1977.tb01008.x

年代:1977

数据来源: WILEY