ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01871.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTSince the activation and condensation of tyrosinase has been found to be carried out in the anastomosing, cysternal and tubular portion of GERL (4–6) rather than the Golgi apparatus, the tyrosinase transfer system from GERL to premelanosomes remains now to be elucidated in initial melanogenesis. Tyrosinase‐rich coated vesicles of Greene's malignant melanoma are isolated by differential ultracentrifugation and DEAE‐sephadex coloumn chromatography. Multiple forms of tyrosinase present in the isolated coated vesicles has been studied in comparison to those present in the soluble fraction. The soluble fraction contains two soluble forms in addition to the membrane bound form of tyrosinase. On ther hand, one soluble form and the membrane bound form of tyrosinase separated from the coated vesicle fraction. The significance of these findings and the possible role of coated vesicles in tyrosinase transport system is disc

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01872.x

年代:1979

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01873.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTThis paper has reported new cases of patients attending the out‐patient clinic of the Department of Dermato‐Venereology, Dr. Cipto Mangunkusumo Hospital, Jakarta, during the period of 1976. A total of 170 types of skin diseases have been diagnosed, among 13514 patients, and four kinds of venereal diseases among 344 patie

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01874.x

年代:1979

数据来源: WILEY

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01875.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTSimultaneous occurrence of bilateral axillary Paget's disease in a 61‐year‐old male with genital Paget's disease of 2 years' duration was presented. Invasive adenocarcimoma was found in the genital lesion. No regional lymph node metastases ware apparent. The lesions were excisedin toto. There has been no recurrence 14 months later.Four previously reported cases of double or triple extramammary Paget's disease, together with two more cases were summarized. Generally, the axillary lesions were clinically insignificant, faintly erythematous patches and could hardly be identified without histological examinat

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01876.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTEnvironmental chemicals (benzene hexachloride(BHC) and dichlor diphenyl trichlor ethane(DDT) as organic chlorides, Sumithion as an organic phosphorated compound and copper powder) were mixed together and administered orally to pedigreed Pitman‐Moor's strain miniature swine for a period of about one year. Oral aphthae, folliculitis, cutaneous and subcutaneous nodules, genital ulcers, hyperemia of conjunctiva and intestinal ulcers were observed in all treated animals.Biopsy and autopsy specimens obtained from the experimental animals showed typical histopathological findings of human Behçet's disease.By ultrastructural X‐ray microanalysis of peripheral neutrophils, vascular endothelial cells and infiltrated cells in affected lesions obtained from the experimental animals, highly significant amounts of chlorine and phosphorus were detected, mainly in the lysosomes.The incidence of Behçet's disease has been reported in countries where pesticides made from organic chlorine, organic phosphorus, arsenic and copper compounds have been used in massive amounts.Therefore, our findings suggest that these environmental chemicals play a main role in the pathogenesis of Behçet's d

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01877.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTGamma‐glutamyl transpeptidase (γ‐GT) activity was measured in a homogenate of penile foreskin, usingγ‐glutamyl‐p‐nitroanilide as a substrate. It was found thatγ‐GT activity was present in both the epidermis and the dermis, being more active in the former.The optimum pH for the enzyme was 8.5–9.0 in Tris buffer, which is similar to that for the rat kidney and human serum enzymes. It was also revealed that glycylglycine was the most effective activator of the enzyme. Some activation was also observed in the presence of L‐glutamine. But L‐methionine, L‐homoserine, L‐glutamic acid, L‐arginine, L‐aspartic acid, glycine and L‐valine inhibited the activity, suggesting that these amino acids do not act as acceptors of theγ‐glutamyl moiety. The enzyme was remarkably inhibited by bromsulphalein, oxidized glutathione, and by L‐serine in the presence of borate. These inhibitions were more severe than thoes observed with

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01878.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTA case of malignant giant cell tumor of the soft tissue in a 59‐year‐old female is presented. Total hysterectomy was performed for uterine carcinoma (histologically squamous cell carcinoma) in 1963, followed by radiation treatment for 6 months. Chronic radiodermatitis developed thereafter on the skin of the hip joint region, buttocks and lower abdominal region. A tumor developed in the lesion of chronic radiodermatitis of the left hip joint region in August 1976 and this was excised on February 23, 1977. Two recurrent tumors and a metastatic lesion in the inguinal lymph node developed, which were surgically removed. The main tumor, measuring 7.5 cm in maximum diameter, was found chiefly in the subcutaneous adipose tissue. Histologically, it was composed of a mixture of fibroblastic spindle‐shaped cells, histiocytic mononuclear cells, bizarre giant cells and osteoclast‐like multinucleated giant cells. Occasionally osteoid tissues were seen. Electron microscopically, undifferentiated cells, fibroblastic cells, monohistiocytic cells, osteoclast like multinucleated giant cells and macrophages were observed, and these cells were considered to be divided into three cell lines, that is an undifferentiated cell line, fibroblastic cell line and histiocytic cell line.The histogenesis of malignant giant cell tumor in this case, is considered to have been from undifferentiated cells to both fibroblastic and histiocytic differentiation through the neoplastic stimulus of ra

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01879.x

年代:1979

数据来源: WILEY

摘要:

ABSTRACTMass‐examination of all 31 employees of a chemical factory revealed that 20 of them were proved or suspected to have contact hypersensitivities to chemical substances used in the factory as follows: 12 cases were sensitive to 2‐amino‐4‐chlorophenol, 5 to para‐aminophenol, 2 to para‐dichloronitrobenzene, and 1 to para‐nitrophenol. Among the 5 compounds tested (including the above 4 substances and 3′‐chlorodiphenylamine‐2‐carboxylic acid), 2‐amino‐4‐chlorophenol was found to be an e

ISSN:0385-2407    

DOI:10.1111/j.1346-8138.1979.tb01880.x

年代:1979

数据来源: WILEY