ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

The Profile of Mood States (POMS) is an instrument composed of six mood scales that were developed using clinical populations. This study examines the replicability of the POMS factor structure in lead-smelter workers and its association with demographic variables and lead exposure. Four hundred sixty-seven current and retired smelter workers completed the POMS, and a factor analysis was performed on the individual items. Two multiple regressions in the currently employed workers (n = 340) with a mean age of 40 years (range, 20-63 years) were used to compare the relationship of the resulting POMS factors with demographic characteristics and two measures of occupational lead exposure: current blood lead level (mean, 28 µg/dL; range, 4-62 µg/dL) and working-lifetime integrated blood lead level (mean, 711 µg-yr/dL; range, 1-1537 µg-yr/dL). Factor analysis produced one factor, labeled "general distress," that was composed mainly of items from five of the six POMS subscales (anger, confusion, depression, fatigue, and tension) and a second factor labeled "psychological adjustment." Demographic variables, including education, age, and alcohol use, were significantly related to the "general distress" factor score. After the effects of the demographic variables were accounted for, the "general distress" factor was significantly related to integrated blood lead level but not current blood lead level. Integrated blood lead level, a measure of cumulative lead exposure that included prior high exposure, was significantly related to the POMS "general distress" factor, while a current blood lead level that was relatively low was unrelated. As expected, POMS psychological adjustment was not related to lead exposure. Factor analysis did not support the use of six separate POMS subscales in this occupational population.

ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Occupational exposure to tetrachloroethene (TCE) has been reported to cause early adverse effects on the kidneys. We investigated the effects of TCE exposure on the kidneys in 82 exposed and 19 nonexposed workers from four dry-cleaning shops in The Netherlands. The mean inhaled amount of TCE in the exposed group, which was assessed by determination of its concentration in alveolar air samples, was 8.4 mg/m3(range, 2.2-44.6 mg/m3). This value corresponds to a mean 8-hour time-weighted average exposure of 7.9 mg/m3(range, 1-221 mg/m3). A chronic dose index (CDI) was estimated from data on the current TCE dose and the occupational history of the individual subjects. The mean CDI in the exposed group was 400 months × mg/m3(range, 12-4882 months × mg/m3). Effects on the tubules were assessed with the parameters N-acetyl-β-D-glucosaminidase, β-galactosidase, alanine aminopeptidase, and retinol-binding protein (RBP) in urine. Early effects on the glomeruli were monitored with the parameter albumin in urine. Total protein in urine was determined for the general assessment of effects on the glomeruli and tubules. The tubular parameter RBP was increased in the exposed group, compared with the nonexposed group. None of the other parameters differed between the study groups, and none of the renal-effect parameters correlated with the TCE dose or the CDI. In conclusion, occupational exposure to TCE may cause a minor effect on the tubular RBP at exposure levels below the Dutch occupational exposure limit (240 mg/m3).

ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Three cases are summarized in which persistent chest wall pain, as well as elevations of creatine phosphokinase (CK) levels, occurred after exposure to chloropicrin vapor in an agricultural chemicals facility. Both the severity of the symptoms and the degree of biochemical abnormality appeared to follow a dose-response relationship. Myoglobinuria, on the other hand, was not found. Elevation of CK after chloropicrin exposure has not previously been reported and may represent low-grade rhabdomyolysis. Workups performed after symptomatic chloropicrine exposure should include CK-level determination.

ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

In patients who are hypersensitive to p-tert-butylphenol-formaldehyde resin (PTBP-F-R), it is necessary, for diagnostic, therapeutic, and preventive reasons, to know the identity of the primary sensitizing substances, their sensitizing capacities, and their crossreaction patterns. The aims of this study were to investigate the presence of a simultaneous p-tert-butylcatechol (PTBC) contact allergy in individuals who were hypersensitive to PTBP-F-R, to investigate the sensitizing capacity of PTBC and p-tert-butylphenol (PTBP) in guinea pigs, and to study any crossreaction patterns. In 294 dermatitis patients tested with PTBP-F-R and PTBC, there was a statistically significant over-representation of simultaneous test reactions. Use of the guinea pig maximization test demonstrated that PTBC is a strong sensitizer giving crossreactions to PTBP. PTBP, however, failed to induce sensitization.

ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

This study estimated the proportion of lung cancer in Greece that was attributable to occupational exposure. Two hundred eighty-two patients with lung cancer and 494 controls were interviewed about their socioeconomic characteristics, sex, age, and occupational, smoking, and residential histories. Each subject was classified as exposed or unexposed to known occupational lung carcinogens. Because of the small number of females exposed, only males were included in the multivariate analyses. When the occupationally exposed subjects were compared with the unexposed subjects and an adjustment for smoking was made, the relative risk for lung cancer was 2.9 (95% confidence interval, 1.95-4.31). If 5% to 10% of the Greek population were occupationally exposed, the attributable risk would be 9.9% to 16.6%, respectively. Occupational exposures conferred an additional risk that was approximately threefold that of smoking alone. Risks increased in a dose-response fashion with increasing cigarette consumption.

ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Hodgkin's disease (HD), a lymphoma with an annual incidence in the United States of approximately 7500 cases, primarily affects the lymph nodes, spleen, and liver. The point of this article is to critically review the literature regarding the purported relationships between HD, certain occupations, and exposure to chemical agents. Attention will also be focused on recent advances in molecular genetics in the etiology of this ailment. A MEDLINE search was conducted to assess case-control and mortality evaluations that investigated links between HD and certain occupations and exposure to designated hazards. A review of citations in the Silver Platter Occupational and Environmental Medicine CD-ROM database was also conducted to ensure that all pertinent reports were obtained. Of the industries evaluated, woodworking showed the most consistent link between an increased risk of HD (relative risk, 1.8 to 7.2), but not all studies conducted showed positive associations. Although certain chemicals (ie, chlorophenols, pesticides) were reported as risks, no chemical was consistently and unambiguously linked with HD. Recent investigative work, however, points to a major etiological role for the Epstein-Barr virus (EBV), genetic fragments of which have been noted in Reed-Sternberg cells, the classic malignant cells of HD. The occupation most consistently associated with HD appears to be woodworking, although no specific chemical has been consistently linked with this lymphoma. The most persuasive evidence regarding the cause of HD arises from recent studies, including epidemiological, clinical, and genetic studies, that point to a major role by the EBV.

ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Medical schools have been slow in teaching students how to recognize and intervene in occupationally and environmentally related illnesses. In this article, we report on the efforts at one medical school, in which an occupational medicine physician teamed with medical school educators developed, implemented, and evaluated an environmental/occupational medicine (EOM) curriculum that was introduced in several locations, using a thematic approach. This effort resulted in new EOM content being added to eight core courses in a developmental sequence and the creation of several elective experiences. We describe techniques and strategies that might be useful at other institutions in promoting the EOM theme and improving communication. Occupational/environmental physicians and educators can play leadership roles in raising interest in EOM within the medical school setting and in developing and implementing an EOM curriculum.

ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Occupational illnesses and injuries are common problems facing workers and employers. The purpose of this study was to determine the nature and extent of illnesses and injuries among hospital workers in Ohio. All workers' compensation claims for 22 hospitals in Ohio during the period 1993-1996 were reviewed. The majority of the claims were for sprain and strain injuries. Most of the claims were approved. Back injury was the leading cause of injury in both genders, and females reported a significantly higher percentage of back injuries. The incidence rates for injuries and illnesses were lower than national rates for other industries. Generally, there was a downward trend in the number of claims during the study period. A negative linear trend in injury rates by hospital size was detected. Our findings suggest the need for safety programs, especially in smaller hospitals, with the goal of preventing sprain and strain injuries.

ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

The United States Bureau of Labor Statistics' (BLS) annual survey of occupational injuries and illnesses (ASOII) is one of the most frequently utilized sources of data on national occupational morbidity. In 1992 the BLS introduced a new and expanded survey method that collects more detailed data on cases with days-away-from-work (DAW). However, to date, the BLS has not released any official publication that contains a comprehensive set of crosstabulated part-of-body (BP) and nature-of-injury (NOI) data. To improve the understanding of national DAW case morbidity estimates, the study presented here utilized a special data-call and data-reduction strategy to identify the leading ASOII BP-NOI combinations for DAW cases by frequency, incidence rate, and severity (median DAW) for 1994. The results indicated the significance of disability associated with discrete trauma (ie, resulting from instantaneous or sudden events) in the US workplace. While morbidity associated with back pain clearly continued as the most frequent type of disabling case, fractures at critical anatomical sites (eg, pelvic region, leg, shoulder) were responsible for the most lengthy disability absences from work in 1994. In some instances these findings were contrary to conclusions typically inferred from BLS publications.

ISSN:1076-2752    

出版商:OVID    

年代:1999

数据来源: OVID