摘要:

61 patients with inoperable non-small cell lung cancer were treated by combination chemotherapy with cisplatin, Adriamycin and cyclophosphamide. 23 patients received radiotherapy in addition to the chemotherapy. 49 out of 55 adequately treated patients were evaluable for tumor response. Of 29 patients who received chemotherapy alone, 6 (21%) achieved partial responses. Of 20 patients who received combined chemotherapy and radiotherapy, 16 (80%) achieved complete or partial responses. The median survival time was 18 months for 22 patients treated with combined therapies.

ISSN:0030-2414    

DOI:10.1159/000225991

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Twenty-two patients with advanced haemopoietic and other malignancies were treated intramuscularly with recombinant interferon-α2C in a daily escalating dose. The most common side-effects were flu-like symptoms. Two patients showed severe neurotoxicity, which was completely reversible in 1 case. Doses above 30 × 106 IU/day were poorly tolerated and could only be achieved in a minority of the patients. Objective tumour responses were documented in malignant lymphomas, hairy cell leukaemia, and renal cell carcinom

ISSN:0030-2414    

DOI:10.1159/000226075

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Oestrogen receptor content, lactoferrin, hexokinase, and glucose-6-phosphate dehydrogenase levels were measured in cytosol from 25 primary breast cancers and 3 fibroadenomas. Both hexokinase and glucose-6-phosphate dehydrogenase activity were higher in malignant tissue as compared to benign breast lesions. Oestrogen receptor concentration and lactoferrin content failed to predict the development of metastatic disease, while glucose-6-phosphate dehydrogenase activity was significantly higher in cytosol from those tumours which subsequently metastasized compared to those which remained localized.

ISSN:0030-2414    

DOI:10.1159/000225992

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Human recombinant interferon-α2C was given to 4 patients with essential thrombocythaemia. Three patients achieved a complete remission on day 19 ± 1 and the 4th achieved a partial remission. After 4 weeks of induction therapy, a maintenance therapy of twice weekly intramuscular injections of 5 × 106 or 10 × 106 IU was instituted but did not maintain the remiss

ISSN:0030-2414    

DOI:10.1159/000226078

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

10 patients underwent hemipelvectomy, mainly for sarcomas originating high in the thigh, or melanomas and epidermoid carcinomas metastatic to the groin. 1 patient died postoperatively, 3 lived 5–12 years and 1 died of unrelated cause 2 years after the operation, all free of recurrence. Tumors treated successfully were large and with indolent locoregional growth, often despite repeated unsuccessful local treatment attempts. These tumor characteristics should be considered as favorable features, in selecting such patients for hemipelvectomy. Conversely 3 patients with melanoma had short history before and died soon after the operation, contraindicating hemipelvectomy in locally advanced melanom

ISSN:0030-2414    

DOI:10.1159/000225993

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A preparation of interferon-α2c of high purity formed by recombinant DNA technology was used as adjuvant therapy following removal of laryngeal papillomas by cauterization or laser vapourization. Preliminary data on 20 patients are reported and include 11 complete and 7 partial responses. Side-effects included initial temperature elevation, but this subsided and other side-effects were uncommon. No antibodies to the interferon preparation were found in any of the patients

ISSN:0030-2414    

DOI:10.1159/000226079

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

B cell DR antigens were studied with lymphocyte markers in the peripheral blood of 62 staged melanoma patients and 37 normal individuals matched for age and sex. 47 patients had early disease (31 in stage I; 16 in stage II) and 15 had advanced disease (stage III). Phagocytic cells were removed prior to testing. Specific rabbit antisera and monoclonal antibodies to purified human B cell DR and Fc molecules were used for detection of membrane immunofluorescence. Mild declines of total lymphocytes and of E-rosetting T cells were observed in comparing early to late disease. The drop of Ig(+) B cells was more striking. DR(+) cells, however, showed no change in percentage and a lesser drop in absolute numbers, suggesting an increase with advancing disease of DR(+), Ig(–) null cells, which may represent immature B cell precursors. Fc(+) cells increased markedly in 14 patients who received levamisole, with little effect on the markers. Elevations of OKT4/OKT8 ratios were seen with a relative reduction in OKT8 cells, especially in late disease. These changes in lymphocyte subpopulations may reflect imbalance between the B and T arms from deranged immune regulation caused by chronic antigenic stimulation from progressively growing tumor. In addition to T cell suppression there is B cell hyperactivity with appearance of immature forms peripherally (shift to left

ISSN:0030-2414    

DOI:10.1159/000225994

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Forty-two patients with multiple myeloma were allocated to two groups to receive either polychemotherapy with vincristine, melphalan, cyclophosphamide and prednisolone, or recombinant interferon-α2C monotherapy. The response rate of 43% in the interferon group was significantly lower than that in the chemotherapy group (89%). Patients with stage I disease showed better response rates than those with stage II or stage III disease. Eleven patients with thrombocythaemia due to polycythaemia vera, chronic myeloid leukaemia or essential thrombocythaemia were treated with recombinant interferon-α2C and complete remissions were achieved in 7 of the 8 evaluable patients. Side-effects were common on interferon therapy, but could be reduced by dose reduction and were reversed by cessation of treatmen

ISSN:0030-2414    

DOI:10.1159/000226080

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Colon adenocarcinoma-associated chromosomal nonhistone proteins were determined in rat colon adenocarcinoma chromatin and in colon chromatin of Sprague-Dawley rats treated with 1,2-dimethylhydrazine (DMH) by the enzyme-linked immunosorbent assay method. The specific nuclear proteins are tissue-specific oncofetal antigens. They were also detected in fetal rat colon chromatin but not in adult rat colon chromatin. The specific tumor-associated nonhistone proteins were identified by immunoblot. The molecular weight ranges of these proteins were 79,000 89,000 and 40,000–56,000 daltons. Administration of DMH to Sprague-Dawley rats induced colon tumor and colon tumor-associated nonhistone proteins in the chromatin. However, DMH failed to induce colon tumor and tumor-associated nonhistone proteins in Lobund-Wistar rat

ISSN:0030-2414    

DOI:10.1159/000225995

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

64 human adenomatous polyps of the colorectal bowel were investigated by histological examination and by flow cytometrical analysis providing DNA distribution patterns. The histological investigation yielded tubular adenomas (TA) in 41 and tubulo-villous adenomas (TVA) in 23 cases. Epithelial dysplasia or carcinomatous degeneration was found in 23 TA and in 11 TVA. Cell cycle stage analysis revealed no different values for TA and TVA without dysplasia, neither for TA and TVA with mild to moderate dysplasia. TVA with severe dysplasia exhibited a significantly higher proportion of cells with G2M phase DNA content than cases without dysplasia or mild to moderate dysplasia. TA and TVA without dysplasia were characterized by diploid DNA distribution patterns. TA with dysplasia showed aneuploid DNA stem lines in 4 of 20 cases, carcinomas arisen from TA in all 4 cases investigated. TVA with dysplasia were characterized by aneuploid DNA stem lines in 1 of 8 cases, carcinomas arisen from TVA in all 4 cases examined. It may be concluded that the DNA distribution patterns do not attribute different biological values to TA and TVA, 2 groups of adenomatous polyps which are characterized by different histological criteria.

ISSN:0030-2414    

DOI:10.1159/000225996

出版商:S. Karger AG    

年代:1985

数据来源: Karger