摘要:

The effect of papaverine on transplantable C1300 murine neuroblastoma model was evaluated. Subcutaneous inoculation of A/J mice with 106 C1300 cells resulted in predictable tumor growth and animal death in 36 ± 5 days. In 33% of control animals, lung and liver metastases were observed. Subcutaneous injections of papaverine prior to tumor inoculation and during the tumor growth failed to show any detectable effect on local growth of the tumor. Benign transformation of the primary tumor was not observed. However, papaverine injection 21 days after tumor inoculation was associated with only 9%incidence of metastatic development. Papaverine treatment, when started one day prior to tumor inoculation or 10 days after tumor implant, resulted in complete prevention of all detectable metastatic growth, while having no apparent effect on local tumor growth. Further study of papaverine effect in the neuroblastoma murine model is indicated

ISSN:0030-2414    

DOI:10.1159/000225245

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The effect on malignant invasion of methyl (5-(2-thienyl-carbonyl)-1H-benzimidazole-2-yl) carbamate, (R17934), a microtubule inhibitor, was examined in organotypical co-cultures of mouse sarcoma virus transformed cells (MO4) and embryonic chick tissues. In contrast with control cultures, 1 microgram/ml R17934 prevented invasion of MO4 cells into the host tissues. Since mitostatic doses of 5-fluorouracil did not inhibit invasion, we presumed that the anti-invasive properties of R17934 were correlated with a loss of microtubule mediated directional cell migration.

ISSN:0030-2414    

DOI:10.1159/000225246

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The effect on cell proliferation of crude granulocyte and thymocyte extracts (GCE, T4) and of their target-specific fractions (Gl-2, T4-1) was studied in cultures with transplantable subacute myeloid and lymphoid leukemia (ML, LL). In the dose rage studied (1–500 μg/ml) each factor reduced 3H-TdR incorporation into acid-insoluble DNA of bone marrow, thymus and spleen cells with ML or LL as a function of the dose, approximately linearly. Normal bone marrow proved to be less sensitive to GCE than the ML one: according to parallel line bioassay by a factor of μ = 0.56. The reactivity of LL spleen and thymus is also higher to medium T4-1 concentrations (50–200 μg/ml) than that of normal lymphoid populations. T4-1 inhibits 3 7 hours. Because of its more homogeneous cell composition and higher sensitivity, subacute myeloid leukemia is more suitable for screening endógenous granuloid inhibitors than are homologous normal cell

ISSN:0030-2414    

DOI:10.1159/000225247

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A certain number of CBA mice injected intraperitoneally with 1 × 106 or fewer Ehrlich ascites tumor (EAT) cells did not develop ascites tumors but solid tumors at the inoculation site. The incidence of solid tumors proved dependent on the level of immunological reactivity of recipients, being increased in mice with increased immunological potency and absent in mice in which this potency was reduced. Mice bearing solid tumors had increased level of cytotoxic antitumor antibodies in serum. Possible reasons for a greater immune resistance of cells growing in subcutaneous tissue, than in the abdominal cavity, are discussed

ISSN:0030-2414    

DOI:10.1159/000225248

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Neoplastic growths seem to interfere with normal processes regulating the serum level of ceruloplasmin, a copper-containing oxidase, which accounts for 96% of serum copper. Normal catabolism of ceruloplasmin in the liver follows desialylation. However, in patients with tumors, ceruloplasmin may be resialylated at the tumor cell surface or in peripheral blood. Decreased catabolism due to resialylation of asialo-ceruloplasmin could account for the increased concentration of serum copper noted in patients with neoplasia.

ISSN:0030-2414    

DOI:10.1159/000225249

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

One hundred and seventeen patients with advanced squamous cell carcinoma of the head and neck were randomised between two combination schedules, one with and the other without adramycin. Responses (more than 50% tumor regression) were 67% overall with 63% responding to the combination without adriamycin and 82% responding to the schedule containing it. The increase in response rate seen with the addition of adriamycin is not statistically significant. Prior radiotherapy reduced the likelihood of response to chemotherapy.

ISSN:0030-2414    

DOI:10.1159/000225250

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Hexamethylmelamine (HXM) is one of the substituted melamines derived from cyanuric chloride [1]. Previous studies with HXM have shown activity against small cell carcinoma of the lung, when it was given as a single agent [2, 3]. Because of relatively mild bone marrow toxicity, HXM was subsequently given in combination with other drugs and/or radiation therapy, in order to improve the therapeutic results. In this paper, our experience with HXM in treatment of small cell carcinoma of the lung is summarised.

ISSN:0030-2414    

DOI:10.1159/000225251

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

L-Asparaginase (NSC-109929) was compared to Cyclophosphamide and placebo in patients with bronchogenic carcinoma. L-As-paraginase when given at 1500 i.u./kg intravenously over a 30 minute period once weekly for six weeks, shortened patient survival time as compared to Cyclophosphamide or placebo. Some preparations of L-Asparaginase when administered at a dosage of 150 i.u./kg gave a beneficial effect similar to Cytoxan and superior to that of placebo while other preparations when administered at the 150 i.u./kg dose level showed a deleterious effect similar to that given by the higher doses. The shortened survival could not be correlated with any obvious drug toxicity. There is some evidence that L-Asparaginase has an inhibitory effect on T cell function and thus depresses cellular immunity. This may account for the shortened survival observed in the lung cancer patients receiving the high doses. The opposite effect seen at the low dose level suggests that an agent which interferes with host defenses at one dose level may enhance it at another. This favorable effect was not observed with all L-Asparaginase preparations. A variation in composition of preparations of L-Asparaginase, especially the endotoxin content, has been observed by others. Cytoxan increased survival by a few weeks as compared to the Placebo. This effect was consistent in the different trials. Cytoxan was equally effective in large cell, squamous cell and adenocarcinoma. Possible reasons for this are discussed in the light of the current information on the histopathology of bronchogenic carcinoma.

ISSN:0030-2414    

DOI:10.1159/000225252

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000225253

出版商:S. Karger AG    

年代:1978

数据来源: Karger