ISSN:0030-2414    

DOI:10.1159/000224715

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The study of biologic properties of nucleic acids from either normal or malignant cells transcends the search for subviral infectivity. The differing results obtained in studying the behavior of nucleic acids from human malignant cells on primary cultures are critically reviewed in the light of the methodology involved. Means of preserving the integrity of the nucleic acid molecule and of suppressing endogenous RNA synthesis in the model cells prior to exposure to the foreign nucleic acid are indispensable in these systems. Of importance, also, is the realization that epigenetic transformation, when it occurs, may be submorphologic and require biochemical, enzymatic and antigenic analysis of the new ‘phenotypic’ proteins. Polysomal structures from different neoplastic cells in different fractions of fluorocarbon homogenates had varied morphology and complexity. Similar complexity was found in cultures treated with RNA from neoplastic cells but not in control cultures of normal cells. A mechanism of de-repression of loci of inactive DNA by near-homologous neoplastic RNA is proposed for the artificial epigenetic transformation of normal cells under suppressed RNA synthesis conditi

ISSN:0030-2414    

DOI:10.1159/000224716

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The interaction nucleic acid-calcium was studied in vitro. RNA is precipitated by CaCl2 while DNA is not. The presence of complexed chromium affects the precipitation of RNA and the physicochemical properties of DNA. The study of the cell fractions from experimental tumors indicate variations in the fraction distribution of calcium and nucleic acids related to the growth stage. The possible role of the cell membranes in the calcification process appears emphasized by the accumulation of calcium and nucleic acids in the microsomal fraction.

ISSN:0030-2414    

DOI:10.1159/000224717

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Appropriate data from the California Tumor Registry and related sources were examined for testicular cancer (ICD No. 178). While there has been a 67-percent increase in the prevalance of testicular cancer in California between 1945–1954 and 1955–1969, there has been no significant increase in its incidence in Alameda County, Calif. (1960–1968). Characteristics of testicular cancer in California include a bimodal age distribution, a median age at diagnosis of 34 years (1955–1969) and an incidence rate of 2.6/100,000. There was no significant difference in the urban versus 0.10). The 5-year relative survival rate has increased from 54 (1942–1954) to 67% (1955–1969) due to a greater localization of the disease at the time of first diagnosis and the increased combination use of surgery and

ISSN:0030-2414    

DOI:10.1159/000224718

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

A mongoloid male was born with stem cell leukemia and mild ABO incompatibility. Transfusion and chemotherapy did not induce remission of the disease or influence its rapidly downhill course. The maternal serum exhibited a cytotoxic antibody against the leukemic cells. After 18 intramuscular injections of maternal serum, neutralized with ABO substances, there followed a remission which has lasted since. The recorded lifespan of true congenital leukemia (91 cases) is from 19 h to 6½ years. The natural role of maternal isoantiserum in spontaneous remissions of congenital leukemia should be considered

ISSN:0030-2414    

DOI:10.1159/000224719

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Polyacrylamide gel disc electrophoresis was employed to analyze changes in serum proteins from normal and tumor-bearing hamsters. A hamster-derived A. melanoma No. 3 was implanted in groups of hamsters and the sera analyzed prior to and after metastatic development. Significant changes were observed in several globulin regions with the most dramatic changes occurring in the α-globulin region.

ISSN:0030-2414    

DOI:10.1159/000224720

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In a continuing study of the effects of inhibition of gluconeogenesis at the phosphoenolpyruvate carboxykinase (PEP CK reaction on in vivo growth of tumors, it has been shown that hydrazine sulfate, a known inhibitor of PEP CK, not only inhibits the Walker 256 intramuscular carcioma, the Murphy-Sturm lymphosarcoma and the B-16 melanoma, but also has an effect on the solid L-1210 leukemia which can be unmasked with the use of an additional inhibiting substance (combination chemotherapy). In addition to hydrazine sulfate various organic hydrazides tested against the Walker 256 intramuscular carcinoma produced varying degrees of tumor inhibition, the most potent being pyridine-2,3-dihydrazide (quinolinic acid dihydrazide) which contains both quinolinic acid and hydrazine, both of which can separately inhibit PEP CK; the latter is thought to account for this compound’s augmented antitumor action. Evidence is presented that tumor inhibition and toxicity (weight loss) may share a common mechanism of action, but if so that these two functions can be separated or toxicity minimize

ISSN:0030-2414    

DOI:10.1159/000224721

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Carotid body tumors are among the most difficult technical problems with which the surgeon must deal. A personal review of 15 tumors occurring in 12 patients is reported with emphasis placed on the relationship of these tumors to multiple endocrine adenomatosis (MEA), their familial and bilateral occurrence, and their unusual locations in the neck. Idiosyncracies of clinical behavior in terms of diagnosis, sites of origin, arteriography, and natural history is examined in depth through a specific patient study. The surgical treatment of these tumors is described which includes a frank discussion of complications and pitfalls.

ISSN:0030-2414    

DOI:10.1159/000224722

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Mitotic figures closely clustered in groups or nests were observed in tissues which grew out from explants of frog lung and salamander liver. Similar nests of mitotic figures were observed in human vaginal smears. In the amphibian tissue cultures nests of cells labeled with tritiated thymidine (3H-TdR) were found which were similar to the mitotic nests. The nest forming phenomenon and the synchrony of the cell cyclein adjacent cells are discussed.

ISSN:0030-2414    

DOI:10.1159/000224723

出版商:S. Karger AG    

年代:1973

数据来源: Karger