摘要:

During March and April 1986 a study of the quality-of-life of cancer patients was done in a medical school-affiliated community hospital in the Midwest, USA. The control group was that of a family practitioner. The experimental group was composed of only those suffering from oncological diseases and the control group of only those without cancer. Ninety-eight experimental patients were studied during 293 visits as were 112 controls during 137 visits. The study instrument was a linear analogue scale of 10 items. Patients were scored from 0 to 10 on each item and then the median, mean, span, and standard deviation were calculated. The means were compared. Overall the control group scored on average 6.67; the experimental group 6.06. This was statistically significant. Subgroups of each practice were then compared with each other, and subgroups of the oncological patients were compared with each other. In general, women in the experimental group did not differ significantly from women in the control group, while men related that they were doing more poorly than did men in the control group and women in the experimental arm. An analysis of exactly where men did worse is made. Lastly, an informed, experienced laywoman attempted to blindly predict, within one point, the scores some consecutive experimental patients would make on their test. She was unable to do this more than 20% of the time.

ISSN:0030-2414    

DOI:10.1159/000226519

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Fifteen patients with low-grade non-Hodgkin’s lymphoma were seen in Harare over a 3-year period, and this group constituted approximately 17% of all non-Hodgkin’s lymphoma. All but one were of type A (Working Formulation), i.e. small lymphocytic. This low proportion of lesser grades of malignancy and virtual absence of follicular histology was similar to findings in other parts of Africa. The clinical features, however, resembled those reported worldwide with the sex ratio equal, older patients affected, and most patients (87%) having advanced stage disease, often with extranodal spr

ISSN:0030-2414    

DOI:10.1159/000226520

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A patient receiving the antitumor agent mitomycin C (MMC) in combination with 5-fluorouracil and adriamycin because of adenocarcinoma of Vater’s papilla manifested hemolytic-uremic syndrome (HUS) after five cycles of 5-fluorouracil-adriamycin-MMC combination chemotherapy. The syndrome most likely was caused by MMC, since an association between HUS and the use of MMC has been observed. We report on the clinical course in such a patient and review the pertinent literatur

ISSN:0030-2414    

DOI:10.1159/000226521

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Four patients with adrenal tumors in whom prolonged fever was the foremost symptom are presented. Two of the patients had nonfunctional adrenocortical carcinoma, one had a pheochromocytoma without adrenergic hyperactivity, and in the fourth, an aldosteronoma was found. Only in 1 case was the tumor (pheochromocytoma) resectable and this patient became afebrile post surgery. A review of the literature revealed that fever is encountered in 6 10% of cases with adrenal tumors, sometimes as the first manifestation of disease. However, a survey of the large series of fever of unknown origin revealed no mention of adrenal tumors in that group of solid tumors which many cause prolonged fever.

ISSN:0030-2414    

DOI:10.1159/000226522

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Tumor infiltrating lymphocytes induced by radiotherapy were analyzed by the biotin-avidin-horseradish peroxidase method. At the early dose of 4 Gy (400 rad) of irradiation (2 Gy × 2), remarkable infiltration of lymphocytes was observed surrounding cancer cells. This infiltration was mainly composed of Leu-3a + 3b-positive lymphocytes, and human leukocyte antigen DR-positive tumor and interstitial cells were remarkably observed

ISSN:0030-2414    

DOI:10.1159/000226523

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A new VP-16-based drug combination was utilized in the treatment of 3 adult patients with acute nonlymphoblastic leukemia. Marrow aplasia was noted in all patients on day 7. While myeloid regeneration was noted on day 14, there was no evidence of regeneration of the erythroid series before day 21 in any of the 3 patients, and maturation of this cell line was never complete before day 35. Such prolonged suppression of the erythroid series has not been described with standard chemotherapy. Because of this protracted suppressive effect of the above regimen on erythroid cells, we propose to explore its therapeutic potential in a pilot study employing such a regimen in the treatment of erythroleukemia.

ISSN:0030-2414    

DOI:10.1159/000226524

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

CA 19-9 and tissue polypeptide antigen (TPA) were determined in the sera of 28 control subjects, 29 patients with pancreatic cancer, 26 with chronic pancreatitis and 62 with benign and malignant extra pancreatic diseases in order to compare their usefulness in diagnosing pancreatic cancer, to verify whether the combined assessment of the two indices could improve the results given by a single parameter and to speculate on the role of liver dysfunction in increasing their serum levels. The sensitivity, specificity and accuracy of CA 19-9 and TPA in diagnosing pancreatic malignancy were: 76, 85 and 61% for CA 19-9 and 79, 52 and 32% for TPA. The receiver-operating characteristic curves showed that CA 19-9 and TPA similarly discriminate pancreatic cancer from controls and chronic pancreatitis, while CA 19-9 is more useful than TPA in differentiating pancreatic malignancy from benign and malignant extra pancreatic abdominal diseases. TPA did not seem to add further information as compared to CA 19–9 alone when both markers were combined. Liver dysfunction may contribute to increasing serum levels of both markers.

ISSN:0030-2414    

DOI:10.1159/000226525

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The relationship of the level of carcinoembryonic antigen (CEA) in the gastric juice to the extent of intestinal metaplasia and gastric cancer, and clinical values of gastric CEA for identifying high-risk patients for gastric cancer were examined. A significant correlation was found between the levels of gastric CEA and the distribution of intestinal metaplasia. Studies were made by the endoscopic Congo red-methylene blue test developed at our hospital. Gastric CEA levels were significantly higher in patients with localized and diffuse intestinal metaplasia than in those with no intestinal metaplasia. The mean levels of gastric CEA in patients with well-differentiated adenocarcinomas were significantly higher than in those with diffuse intestinal metaplasia. They were also significantly higher in patients with poorly differentiated adenocarcinomas than in patients with no intestinal metaplasia, but not significantly higher than in those with diffuse intestinal metaplasia. Endoscopic follow-up examinations show that gastric cancer was detected in only 1 patient with a gastric CEA level of 10 ng/ml or more, but in none of those with gastric CEA of less than 10 ng/ml, during the average observation period of 4.3 years. These results indicate that gastric CEA is produced both by intestinal metaplasia and well- and poorly differentiated adenocarcinomas, and that gastric CEA is useful in identifying high-risk patients for gastric cancer.

ISSN:0030-2414    

DOI:10.1159/000226526

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The photodynamic inactivations of Walker carcinosarcoma 256 stomach tumors by the concomitant use of acridine orange (AO) and argon laser, and by the combined use of hematoporphyrin derivatives (HPD) and dye laser were compared. Wistar rats bearing stomach tumors of 4–6 mm in diameter 5–10 days after their implantation were injected intraperitoneally with 40 mg/kg body weight of AO or HPD, and 24 h later their stomach tumors were exposed to argon laser at 488 nm or dye laser at 630 nm, respectively, at an intensity of 15 mW/cm2 for 20 min. Temperature rise was less than 3°C during irradiation. Seven days after irradiation, complete or partial necrosis with sparing of the surrounding mucosa was seen histologically in all rats treated by the two therapy methods. Phase contrast and electron microscopy showed nuclear pyknosis and damage to the inner layer of the nuclear envelope in tumor cells treated with AO and argon laser, while cytotoxicity involved damage to the outer layer of the nuclear envelope and intracytoplasmic organelles in tumor cells treated with HPD and dye laser. This difference between AO and HPD is considered to be a difference in their intracellular localization in tumor c

ISSN:0030-2414    

DOI:10.1159/000226527

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The present report primarily describes protective effects of a long-term prophylactic treatment with 3-amino-1-hydroxypropane-1,1-bisphosphonic acid (APD) on the development of tumor-induced osteolytic bone destructions. Pretreatment with daily intravenous doses of APD 9.5 mg/kg for 1 week resulted in a significant reduction of Walker carcinosarcoma 256-induced bone destruction, when Walker cells were transplanted intraosseously (2 × 106 tumor cells/rat) 7 weeks later. Shorter pretreatment periods (4, 2 or 1 week prior to tumor inocculation) resulted in a nearly total inhibition of bone destruction as well as tumor-induced hypercalcemia. Tumor growth itself was not inhibited by APD pretreatment. Histological and microradio-graphical findings are reported. Consistent to our experiments and with regard to new immunocytological methods to detect single metastatic tumor cells in the bone marrow, potential risk groups may be defined which may profit from the prophylactic APD treatment to inhibit tumor-induced bone destructions

ISSN:0030-2414    

DOI:10.1159/000226528

出版商:S. Karger AG    

年代:1988

数据来源: Karger