摘要:

Recently, prostacyclin (PGI2) has been used for the treatment of preeclampsia. In this study, we investigated the effects of PGI2 on placental blood flow (measured with clearance of hydrogen gas generated by electrolysis) in normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The placental blood flow of PGI2-treated SHR (0.25, 0.5 and 1 mg/kg) was significantly (p < 0.05) reduced compared with WKY. These data suggest that PGI2 has a certain reducing effect on placental blood flow in SHR; on the other hand, in WKY, it has an increasing effect depending on the dose.

ISSN:0378-7346    

DOI:10.1159/000294881

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Like the endometrial stroma, the decidua contains lymphoreticular cells, and these are probably involved in immunological interactions between the conceptus and the mother. Lymphoreticular cells in decidual tissue obtained from 12 patients undergoing therapeutic abortion of an intact pregnancy at 6–10 weeks’ gestation were investigated in this study. Immunophenotyping with a broad panel of monoclonal antibodies revealed various subpopulations of lymphoreticular cells. Macrophages (Ki-M6+, Ki-M7+, Ki-M8+, KP1+, MAC 387+ and Ki-M1P+) represented the largest fraction of intradecidual lymphoreticular cells. CD3+ and CD8+ lymphocytes were found in moderate numbers and CD4+ cells in small numbers. The majority of the intradecidual lymphoid cells exhibited an unusual phenotype [CD7+, CD2+, CD56+, triple negative (CD3––, CD4––, CD8––)]. The distribution of these unusual lymphocytes mirrored that of the so-called endometrial stromal granulocytes. A few of these stromal granulocytes reacted with the macrophage-associated antibody KP1, but not with Ki-M1P, another macrophage marker. This was confirmed by immuno-electron microscopy. The finding that intradecidual CD3+ lymphocytes express neither the α/β nor the γ/δ heterodimer of the T cell antigen receptor was unexpected. However, these cells did express the α/β heterodimer after in vitro culture with PHA-P and recombinant exogenous interleukin-2. No stimulated T lymphocytes expressing activation antigens could be detected. B lymphocytes, T and B immune accessory cells and CD 15+ granulocytes were found only in small numbers or were absent. Amongst cells expressing NK cell markers, CD 5 7+ and CD 16+ cells were found in small to moderate numbers, while CD 5 6+ cells were detected in large numbers. The potential role of decidual stromal granulocytes in regulating the development of early human pregnancy is discussed.

ISSN:0378-7346    

DOI:10.1159/000294882

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

A soluble extract from human placenta was found to neutralize heparin in a factor Xa-dependent heparin assay system. In comparison with serum the antiheparin activity of placenta tissue is 10 times higher (extract from 1 g of placenta neutralizes 8.94 ± 3.31 IU of heparin; 1 ml of serum approximately 1 IU). The substance neutralizing heparin has not been identified, but it has been found that it is nondialyzable, is not adsorbed on heparin-Sepharose, and does not act progressively. It was suggested that the substance(s) responsible for the antiheparin effect in vitro might contribute to the failure of heparin to penetrate the placenta in vivo (placental barrier to heparin).

ISSN:0378-7346    

DOI:10.1159/000294883

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Fetal and early neonatal atrial measurements correlating with plasma atrial natriuretic peptide were studied to evaluate the circulatory change before and after delivery in a longitudinal study of 10 normal fetuses from 1 week before until 5 days after delivery. Before delivery, right atrial area value was significantly larger than that of left atrial area; however, there were no significant differences between left and right atrial areas after delivery. Right atrial area value before delivery was significantly larger than those after delivery, whereas the left atrial area did not change before and after delivery. Combined atrial area value before delivery was also larger than those after delivery. Plasma atrial natriuretic peptide values did not change after delivery. These results suggest that the change from fetal to neonatal circulation mainly caused by the pulmonary circulation induces the change of right atrial size before and after delivery.

ISSN:0378-7346    

DOI:10.1159/000294884

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

To determine the possible effects of α-methyldopa on the motility of human umbilical artery, a total of 53 arterial segments were perfused with different concentrations of the drug as follows: 38 segments with 125, 250 and 500 ng/ml of the drug, 9 segments with 500 ng/ml α-methyldopa in combination with 10––7M yohimbine, and 6 segments with 10––7M yohimbine alone. α-Methyldopa had a vasoconstrictor effect at all doses employed, with a clear dose-effect correlation (p < 0.01). The vasoconstrictor effect of 500 ng/ml α-methyldopa was fully inhibited in the presence of 10––7M yohimbine. These results suggest that α2-adrenergic receptors are present in the umbilical circulation and that α-methyldopa may play a role in the control of this circulation.

ISSN:0378-7346    

DOI:10.1159/000294885

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

A total of 261 women in early pregnancy, either with mild symptoms of ectopic pregnancy (EP) or being at an increased risk for this condition, were included in a longitudinal study. The effectiveness of different diagnostic measures in obtaining correct final diagnoses was analyzed. In addition to clinical findings and symptoms, the use of serum human chorionic gonadotropin, serum progesterone, endovaginal sonography and a risk score for EP were all proven to be valuable in distinguishing normal intrauterine pregnancies from pathological pregnancies.

ISSN:0378-7346    

DOI:10.1159/000294886

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

A total of 171 consecutive high-risk parturients in Maputo Central Hospital were studied regarding post-partum contraceptive choice in order to plan a new post-natal clinic approach in maternal health care. It was found that contraceptive interest was much less in women with experience of child loss than in women with all children surviving (p < 0.005). The findings were useful in planning various measures to meet the documented demand for available methods under adverse circumstances of scarce manpower and material resources.

ISSN:0378-7346    

DOI:10.1159/000294887

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

The simultaneous effects of cigarette smoking and oral contraceptives on serum estradiol and progesterone levels were investigated in 114 premenopausal women. Serum 17β-estradiol and progesterone levels were measured by radioimmunoassay. In smokers, estradiol and progesterone levels were significantly lower (p < 0.025). In smokers using oral contraceptives, estradiol and progesterone levels were the lowest (p < 0.001 and p < 0.01, respectively). The findings suggest that smoking and oral contraceptives independently lower serum estradiol and progesterone concentrations in premenopausal women and that the effects may be additive.

ISSN:0378-7346    

DOI:10.1159/000294888

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

A comparison of the subjectively measured cervical dilatation and the dilatation measured objectively with a force-sensing instrument connected to metal dilators was made in two studies of cervical treatment prior to first trimester abortion. It was concluded that the subjective method is a sensitive and accurate method of measuring cervical dilatation but does not allow for comparison between different studies where an objective method of measurement should be used.

ISSN:0378-7346    

DOI:10.1159/000294889

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Lumbar bone mass (LBM) determination by quantitative computerized tomography in pre-, peri- and postmenopausal women was utilized to identify subjects at risk to develop osteoporosis. The results were related to determinations of bone metabolic markers (serum osteocalcin and urinary calcium excretion). Osteocalcin was the only metabolic marker which underwent significative changes. However, we found very poor correlations between LBM and metabolic markers and it is concluded that bone mass determination remains the method of choice to select women for preventive therapy.

ISSN:0378-7346    

DOI:10.1159/000294890

出版商:S. Karger AG    

年代:1992

数据来源: Karger