ISSN:0378-7346    

DOI:10.1159/000300972

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000300973

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Estriol (E3) and estradiol (E2) was given to 81 women with perimenopausal complaints. Venous blood was sampled before and after 2 weeks’ treatment. In plasma coagulation and fibrinolysis the most marked estrogen effects were seen within the extrinsic coagulation system, with increased Thrombotest and Normotest activities. The incidence of cold activation of factor VII showed a marked increase after treatment with 6 mg of E2 or 8 mg of E3. The cold activation of factor VII was correlated to an activation of the plasma kallikrein system, as revealed by the peptidase activity of plasma kallikrein. The treatment with E2 and E3 induced changes also in the plasma proteolytic capacity, and in some proteinase inhibitors (antithrombin III, C1 inactivator). Like the effects within the plasma coagulation and kallikrein systems, these effects were similar to those reported after treatment with ethinyl estradiol, mestranol, and diethylstilbestrol, and in pregnancy. The conclusion is drawn, therefore, that the coagulation and fibrinolytic effects of E2 and E3 are basically similar to those of other estrogens, the differences between the various estrogens being more of a quantitative than of a qualitative nature. For the changes described, no absolute dose dependency could be found. Thus, treatment with E2 and E3 should be submitted to the same precautions as treatment with other estrogens.

ISSN:0378-7346    

DOI:10.1159/000300974

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The influence of metronidazole on some strains of facultatively anaerobic bacteria was studied. In high doses similar to those used for local treatment the growth of some strains was clearly suppressed, moreover there was an inhibition of hemolysis in hemolytic strains even when they were found to be resistant to the drug. Results are of particular importance for clinical problems as they might explain a number of alterations in the microbial flora of the vagina during and after therapy with metronidazole.

ISSN:0378-7346    

DOI:10.1159/000300975

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

30 asthenozoospermic subfertile men were treated parenterally for 3 months with kallikrein. 20 men showed a significant increase in sperm motility, 66% (responders), while the other 10 men, 34% (non-responders), did not respond to this treatment. A striking decrease in sperm concentration (by 32%) was found in most patients. No latent period was found following kallikrein treatment. Thus, semen quality did not differ if examined immediately following the cessation of treatment or a few weeks afterwards. A poor pregnancy rate was recorded, i.e. 20% among the responders and 10% among the non-responders. In conclusion, kallikrein is a useful drug in the treatment of asthenozoospermia only when the sperm concentration is not decreased below the optimal value.

ISSN:0378-7346    

DOI:10.1159/000300976

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Flufenamic acid (FA), an inhibitor of the synthesis and action of prostaglandins, was administered to 18 women with preterm labor during the 28th to 36th week of gestation. In 15 patients delivery was postponed, the mean admission/delivery interval being 21.5 days. 2 patients with cervical dilatation of 4 cm delivered within 48 h despite medication. The peripheral plasma levels of 15-keto-13,14-dihydroprostaglandin F2α (KH2 PG2α) was high on admission (216 ± 24 pg/ml, mean ± SEM), declined by 50% within 2 h of instituting treatment and remained near the normal level seen in 13 controlled women after the 24th hour.

ISSN:0378-7346    

DOI:10.1159/000300977

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

174 patients with suspected tubal pregnancy were thoroughly examined. The diagnosis was confirmed in 102 women. As the usual noninvasive and invasive examination methods proved to be rather inaccurate, a new procedure, the ‘LH/HCG test’, was evaluated. Results were positive in all our cases. It was therefore concluded that this assay should receive primary consideration when tubal pregnancy is in question.

ISSN:0378-7346    

DOI:10.1159/000300978

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000300979

出版商:S. Karger AG    

年代:1978

数据来源: Karger