ISSN:0378-7346    

DOI:10.1159/000290761

出版商:S. Karger AG    

年代:1913

数据来源: Karger

摘要:

Twenty hyperprolactinemic patients who entered a randomized parallel-group, double-blind, double-dummy study were investigated regarding safety, tolerability and efficacy. Half of the patients received 5 mg Parlodel® SRO plus placebo for Parlodel while the other half received 2.5 mg Parlodel b.i.d. and placebo for Parlodel SRO for a period of 15 days. In the second following period of 15 days, the daily dose was increased to 10 mg Parlodel administered either as a single dose of Parlodel SRO or two doses of Parlodel 5 mg. The plasma prolactin levels, clinical signs and symptoms of hyperprolactinemia, physical examination, blood pressure, heart rate assessments and adverse events were recorded during the study. Complete blood count, blood chemistry and standard ECG were performed before and at the end of treatment. In conclusion, both formulations are equally efficacious, well tolerated and safe. Due to the comfort of once-a-day administration and the excellent compliance, one could recommend to replace the b.i.d. or t.i.d. administration of Parlodel with the once-a-day Parlodel SRO in hyperprolactinemic patients

ISSN:0378-7346    

DOI:10.1159/000292510

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Digoxin-like immunoreactive substance (DLIS) has been proposed to have a role in what seems to be the timely onset of labor. The relationship between the DLIS in patients with preterm labor and the success of tocolytic therapy with ritodrine and nifedipine has been studied. Using a commercially available radioimmunassay kit, DLIS levels were determined in a total of 47 women with preterm labor and in 30 control. Tocolysis was successful in 37 of 47 women, in 20 of whom nifedipine and in 17 ritodrine was the tocolytic agent. Mean DLIS concentration was higher in patients with preterm labor. Moreover, DLIS levels were found to be decreased by successful tocolysis as could be observed from the values before initiation of tocolytic therapy and on the 3rd day of tocolysis for both nifedipine (0.268 ± 0.198 vs. 0.220 ± 0.210 ng/ ml) and ritodrine (0.250 ± 0.176 vs. 0.196 ± 0.147 ng/ml; Wilcoxon test, p < 0.05).

ISSN:0378-7346    

DOI:10.1159/000292511

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Once a diagnosis of early pregnancy failure has been made, it is normal gynaecological practice to proceed to evacuation of any retained products of conception. In many cases, however, there may be little residual tissue within the uterus, and the patient may be exposed to an unnecessary operative procedure. The purpose of this study was to use sonographically derived measurements of the uterine cavity to select cases suitable for conservative management. Of 50 women presenting with a diagnosis of spontaneous abortion, 32 were chosen for non-operative treatment based upon their uterine cavity measurements. In all of these cases, bleeding had ceased within 2 weeks of selection and the pregnancy test had become negative. There were no subsequent complications. In our opinion, sonographic examination of the uterus allows the selection of those cases which can safely be managed conservatively.

ISSN:0378-7346    

DOI:10.1159/000292512

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

One hundred and thirteen cases of polyhydramnios diagnosed by repeated ultrasonic examinations in singleton pregnancies were divided into two groups according to the trend of change in the amniotic fluid volume between the first and the second ultrasonic examination. Group A patients (65 cases) showed an increase or no change in amniotic fluid volume, and in group B (48 cases) a reduction in amniotic fluid volume to mild polyhydramnios or to normal amniotic fluid volume was observed. A significantly increased rate (p < 0.05) of maternal complications such as diabetes mellitus, pregnancy-induced hypertension, urinary tract infections, premature rupture of membranes and premature delivery was observed in group A. More abdominal deliveries and an increased rate of fetal anomalies, fetal abnormal presentations, intrauterine fetal death and neonatal death also occurred in this group. Group B patients, most of whom were idiopathic, showed a very favorable outcome.

ISSN:0378-7346    

DOI:10.1159/000292513

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

The objective of this report was to study the effect of oxytocin augmentation in arrest disorders in the presence of thick meconium on meconium aspiration and fetal acidosis. We evaluated 3,321 singleton, term deliveries with cephalic presentation at our institution. Eight percent (253/3,321) had thick meconium in labor, and these patients comprised the study sample. Of the 253 women with thick meconium, 84 had an arrest disorder in the active phase of labor with normal fetal heart rate tracing at the time of diagnosis. Seventy-four percent (62/84) of the women with arrest were treated with oxytocin (group 1) and 26% (22/84) delivered by cesarean section without augmentation (group 2). There was a significant (p < 0.05) increase in the incidence of meconium aspiration (14.5 vs. 4.5%) and low ( < 7.20) cord arterial pH (27.8 vs. 4.5%) in patients who received oxytocin compared to those who did not. Of the women who received oxytocin, 36 delivered vaginally, and 2 neonates had meconium aspiration. The remaining 26 women had cesarean sections following oxytocin augmentation and had a significantly higher (p < 0.05) frequency of meconium aspiration (26.9 vs. 4.5%) and low cord arterial pH (38.5 vs. 4.5%) compared to women who had cesarean sections without oxytocin augmentation. The findings suggest that oxytocin augmentation in arrest disorders in the presence of thick meconium may be associated with a higher risk of meconium aspiration and low umbilical cord arterial pH.

ISSN:0378-7346    

DOI:10.1159/000292514

出版商:S. Karger AG    

年代:1994

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000290762

出版商:S. Karger AG    

年代:1913

数据来源: Karger

摘要:

Glycosylated hemoglobin (HbA1) levels were compared in low risk pregnant Singaporean women with normal and abnormal glucose response. HbA1 (mean ± 1 SD) levels in normal and abnormal groups (489 and 72, respectively) were 4.65 ± 0.49 and 4.85 ± 0.50, respectively. While mean levels were significantly different, there was a considerable overlap of levels in both groups. At various gestation periods, mean HbAi levels between normal and abnormal groups showed significant difference only at late gestation. The latter may have contributed to significant differences in HbA1 levels between normal and abnormal groups as a whole. The considerable overlap of HbA1 values in normal and abnormal groups indicate that HbA1 may be insensitive as a screening method for glucose intolerance.

ISSN:0378-7346    

DOI:10.1159/000292515

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Maternal thyroid function was investigated in 37 preeclamptic and 8 eclamptic patients and 45 normal pregnant women in the third trimester as controls. There were significant correlations between maternal values of total thyroxine (TT4), total triiodothyronine (TT3), thyroxine-binding globulin, free thyroxine index and birth weight of newborns in the patients with preeclampsia-eclampsia, but there was no correlation in the controls. Also, the maternal free thyroxine, free triiodothyronine, triiodothyronine uptake and thyroid stimulating hormone values showed no correlation with the birth weights of babies in both groups. The reduced serum concentrations of TT4 and TT3 may reflect the severity of preeclampsia.

ISSN:0378-7346    

DOI:10.1159/000292516

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

This incident case-referent study was conducted at Harare Maternity Hospital in 1989–1990 on 104 consecutive cases of stillbirth with unknown aetiology and 96 age- and parity-matched referents. Information was collected by interviewing the women following a standardized form and by review of antenatal cards. None of the women refused to participate. The most significant obstetric risk factors were prevalence of earlier stillbirths (odds ratio, OR = 6.1) and miscarriages (OR = 4.8). Low height and body mass index also increased the risk of having a stillborn baby significantly as well as a history of flue-like illness during pregnancy (OR = 4.6). The latter may have stimulated the women to book early causing the unexpectedly high OR for early booking among these cases. The pattern for the socio-economic risk factors was not easy to interpret. The most striking finding was the U-shaped relationship between socio-economic status and stillbirths with a higher risk among those with low and high statu

ISSN:0378-7346    

DOI:10.1159/000292517

出版商:S. Karger AG    

年代:1994

数据来源: Karger