摘要:

The transfer of phosphomycin across the placental barrier was studied after a single injection of the sodium salt of phosphomycin to the mother during active labour. The concentrations of the antibiotic in maternal and fetal blood were determined and a high and rapid transfer of the antibiotic, reaching 50% of the maternal blood level after 1.5 h, was observed, which theoretically could be effective in the fetus against a large number of the germs which can be responsible for intrauterine infections.

ISSN:0378-7346    

DOI:10.1159/000301631

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Mycoplasma hominis I is known to spread systematically and to cause occasional illness in humans. M. hominis I a common commensal in the vagina of women, was used in a rat model to create intravaginal infection as a means of elucidating a route toward possible teratogenesis. M. hominis I was cultured from the vagina of one of eleven rats 3 days following a series of intravaginal inoculations of the organism. Intraperitoneal injections of M. hominis I with Freund’s complete adjuvant (FCA) in the same rat model caused an increasing humoral antibody response in all rats injected and produced a 17-day sepsis in one rat. Three pregnant rats inoculated intraperitoneally with M. hominis I in FCA yielded mycoplasma from uterine blood at 1 or 2 days; and 14 of 30 placentas and 8 of 30 fetuses. The route of mycoplasma infection to the fetus appears to be from maternal blood to placenta and not via ruptured membranes.

ISSN:0378-7346    

DOI:10.1159/000301633

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

It is now known that a woman who has given birth to a large child or children is to be regarded as a potential diabetic. It has also been suggested that, in addition to the mother’s unfavorable environment, the high birth weight might be an inherited characteristic linked in some way to the diabetic genetic make-up of the father. The authors have investigated carbohydrate metabolism by means of a 3-hour oral glucose tolerance test in 50 couples, mothers and fathers who had given birth to giant infants (weighing 5 kg or more). Glucose tolerance was compared to that of 50 other couples, mothers and fathers of infants with average birth weight. The latter served as a control group. Nine women (18%) in the test group had a diabetic O-GTT, as compared to three (6%) in the control group. Five men in the test group (10%), and two in the control group (4%) had diabetic-type curves. Statistical evaluation of women and men as groups showed glucose tolerance to be significantly lower in the test groups as compared to the control groups, respectively. It was concluded that results of our study are in accordance with investigators who found deterioration of carbohydrate metabolism in mothers and fathers of excessive-sized babies.

ISSN:0378-7346    

DOI:10.1159/000301636

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The permeability of the vaginal mucosa for viruses in pregnant and non pregnant mice has been investigated. As a virus model, a T3-phage suspension labeled with methylene blue was inoculated into the vagina. 18 min after application of the suspension in pregnant mice, phages were detected in circulating blood by in vitro tests. In non pregnant mice, a phagemia was noted 8 min later. The rapid permeability of the vaginal mucosa for viruses during pregnancy has been substantiated by a simultaneous excretion of dye in gastric fluid and in urine. These observations may be due to the hyperemia and increased pelvic blood flow of the genital tract during pregnancy.

ISSN:0378-7346    

DOI:10.1159/000301637

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

25 fetal lambs with a mean gestational age of 139 days were maintained in the fetal state by extracorporeal gas exchange for periods of 1–11 h and intentionally terminated at a mean of 4 h. Pao2, Paco2, pH, umbilical blood flow, heart rate, arterial blood pressure, blood glucose and serum electrolytes were maintained within the fetal range. The hematocrit of 30%, was 25% below in utero values due to dilution with priming blood. Hemolysis occurred at a rate of 2 mg hemoglobin/100 ml plasma/h, with a mean drop in hematocrit of 6% in 4 h. Metabolic acidosis was the most common problem. The cardiac output, measured in five lambs using radioactive microspheres, was 65% of in utero values. The fractional distribution appeared normal. It is hypothesized that mild tissue hypoxia, secondary to the reduced cardiac output and reduced oxygen capacity of the blood, was the most likely source of the metabolic acidosi

ISSN:0378-7346    

DOI:10.1159/000301640

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000278856

出版商:S. Karger AG    

年代:1897

数据来源: Karger

摘要:

The corpus luteum was first clearly described by Regner de Graaf (1672). That it is an organ of internal secretion was suggested by Louis-Auguste Prenant in 1898 and by Gustav Born about the same time. Clues to its specific action upont the endometrium were discovered through experiments by Ludwig Fraenkel (1903 and 1910), by Leo Loeb (1907) and by Paul Ancel and Paul Bouin (1910). The control of uterine motility by the corpus luteum was demonstrated by Hermann Knaus (1927 ff.). G.W. Corner (1928) demonstrated the necessity of the corpus luteum for survival of the pre-implantation embryo. Using a test based upon Fraenkel and Ancel/ Bouin, Corner and W.M. Allen isolated the hormone progesterone (1929) and first maintained pregnancy with corpus luteum extracts after early ablation of the ovaries (rabbit, 1930). Purification of progesterone was the work of several investigators between 1928 and 1934. The structural formula was worked out by Adolf Butenandt (1933–1934).

ISSN:0378-7346    

DOI:10.1159/000301641

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000278857

出版商:S. Karger AG    

年代:1897

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000301643

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000301644

出版商:S. Karger AG    

年代:1974

数据来源: Karger