ISSN:0378-7346    

DOI:10.1159/000299919

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (HPRL), 17β-estradiol (E2) and progesterone (P) were estimated in 46 subjects with normal menstrual cycles in whom hysterectomies were performed. Estrogen (ER) and progesterone receptor (PgR) levels in endometrial samples of these patients were estimated, and histological dating of the cycle day was carried out. Similarly, hormone serum levels and ER as well as PgR were estimated in 17 patients with endometrial carcinoma. No correlation between LH, FSH, HPRL and ER as well as PgR was noted in the normal subjects. Correlation between P and ER was observed in this group. Parallel variations between E2 and PgR were recorded in the normal females. In the carcinoma group no correlations between hormone serum levels and receptor contents were found, but ER and PgR correlated with each other. Receptor levels were highest in the well-differentiated group of endometrial carcinoma. The present experiments provide a rationale for progestagen therapy of carcinoma of the endometrium.

ISSN:0378-7346    

DOI:10.1159/000299920

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The effect of fenoterol and norepinephrine was studied on the vascular resistance of in vitro perfused human ovary. It was found that the β-adrenergic stimulant fenoterol causes vasodilatation, whereas the α-adrenergic stimulant norepinephrine elicits vasoconstriction in the arterial vascular bed of the ovary showing the role of adrenergic mechanism in the regulation of ovarian blood flow. It was supposed that therapeutical administration of β-mimetic drugs leads to the elevation of ovarian blood flow, which may have special importance in the case of corpus luteum insufficiency.

ISSN:0378-7346    

DOI:10.1159/000299921

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The authors investigated 5 Japanese cases of cerebrovascular accidents among users of oral contraceptives; 4 previously reported and 1 of their own. It is estimated that 200,000 women in this country use oral contraceptives, but, as of the present, only 5 cases of resultant cerebrovascular accidents have been reported. Of particular interest is the fact that 3 of the women had undergone multiple artificial abortions. The appearance of the side effects was dose independent and the symptoms were aggravated for 2 weeks after the cessation of medication.

ISSN:0378-7346    

DOI:10.1159/000299922

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The influence of lisuride, a new semisynthetic ergot derivative, was investigated in women during the puerperium. Treatment with 600 or 900 μg lisuride over 14 days (each test group n = 25) caused an immediate drop of the elevated prolactin (PRL) levels in all patients in comparison to values seen in normal, nonpregnant women ( < 30 ng/ml). Such a sharp decline was not seen in two control groups of puerperal patients, nursing as well as nonnursing, placebo-treated women. The clinical efficacy in preventing or suppressing lactation was clear cut and comparable to the known PRL lowering effect of bromocryptine. Severe side effects were not observed during lisuride treatment with these dosages. The postsuckling PRL increase was abolished by a single oral dose of lisuride (100, 200, 300 μg), similar to that seen with bromocryptine (2.5 mg). The inhibition was dose dependent. Only doses of 200 and 300 μg showed, in comparison to a placebo group, a significant long-lasting ( > 8 h) suppression of PRL secretion.

ISSN:0378-7346    

DOI:10.1159/000299923

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Uteroplacental blood flow was studied with a noninvasive method using indium-113m and a computer-linked gammacamera. The blood flow was determined from the ratio of the maximum and the rise time of the isotope accumulation curve of the placenta. Eight pregnancies with intrauterine growth retardation (IUGR) were compared with 11 normal pregnancies. In the IUGR group the mean placental blood flow was only 1/4 of corresponding mean values of the mormal group. The difference was highly significant (p < 0.01).

ISSN:0378-7346    

DOI:10.1159/000299924

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The authors present a protocol for the interpretation of the fetal heart rate during the second stage of labour (limited to the last 30 min before delivery). The FHR recordings were grouped according to five classes of increasing pathological significance. Good correlations were obtained between these classifications and the Apgar score as well as the umbilical artery pH.

ISSN:0378-7346    

DOI:10.1159/000299925

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299926

出版商:S. Karger AG    

年代:1979

数据来源: Karger