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1. |
Introductory Statement |
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International Reviews of Immunology,
Volume 1,
Issue 3-4,
1986,
Page 213-214
LynchRichard G.,
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ISSN:0883-0185
DOI:10.3109/08830188609056607
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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2. |
Developmental Aspects of Immunoglobulin Gene Expression Using Tumor Cells as Models |
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International Reviews of Immunology,
Volume 1,
Issue 3-4,
1986,
Page 215-235
MatherElizabeth L.,
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PDF (1077KB)
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ISSN:0883-0185
DOI:10.3109/08830188609056608
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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3. |
The Occurence, Structural and Functional Properties of Immunoglobulin Fc Receptors on Murine Neoplastic Cells |
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International Reviews of Immunology,
Volume 1,
Issue 3-4,
1986,
Page 237-271
NeauportCatherine,
DaëronMarc,
LucJean,
BlankUlrich,
FridmanWolf Herman,
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PDF (1626KB)
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ISSN:0883-0185
DOI:10.3109/08830188609056609
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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4. |
Host-Tumor Interactions in the SJL Lymphoma Model |
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International Reviews of Immunology,
Volume 1,
Issue 3-4,
1986,
Page 273-301
PonzioNicholas M.,
BrownPowell H.,
ThorbeckeG. Jeanette,
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PDF (1523KB)
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ISSN:0883-0185
DOI:10.3109/08830188609056610
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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5. |
Therapeutic Strategies for B Cell Malignancies Involving Idiotype-Anti-idiotype Interactions |
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International Reviews of Immunology,
Volume 1,
Issue 3-4,
1986,
Page 303-333
StevensonF. K.,
StevensonG. T.,
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摘要:
The therapeutic use of unmodified monoclonal anti-idiotypic antibody for human B cell malignancies has met with limited success. Some factors thwarting antibody attack can be identified, such as the presence of extracellular idiotypic immunoglobulin (Ig), and the escape of the target cell by antigenic modulation. Another possibility is a change in idiotypic determinants due to somatic mutation.For direct attack on tumor cellsin vivoit might be necessary to use antibody derivatives: univalent antibodies will avoid modulation, and chimeric univalent antibodies consisting of mouse Fabγlinked to host Ig of appropriate subclass can be engineered to mediate particular effector functions while reducing immunogenicity. Another approach is to use toxin or isotope-bearing antibodies. However, the final eradication of tumor might involve the natural non-specific, and specific anti-idiotypic mechanisms of the host which should not be damaged by antibody therapy, and which appear to be involved in control of tumor progression in patients in long-term remission.Rapidly growing animal lymphomas presently available as models cannot mimic more than a small fraction of human lymphoma but they provide useful information for design of passive anti-idiotype therapy. However host anti-idiotypic immunity must be induced in such models by pre-immunization with purified idiotype. Such a procedure can generate effective antiidiotypic immunity which is highly protective in mouse and guinea pig lymphomas. Analysis of mechanisms involved should give insight into the role of the idiotype networks in the behavior of human disease.
ISSN:0883-0185
DOI:10.3109/08830188609056611
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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6. |
Components of Immune Function Studied with Lymphoid Tumors |
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International Reviews of Immunology,
Volume 1,
Issue 3-4,
1986,
Page 335-348
LynchRichard G.,
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PDF (754KB)
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ISSN:0883-0185
DOI:10.3109/08830188609056612
出版商:Taylor&Francis
年代:1986
数据来源: Taylor
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