ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05138.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05139.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05140.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05141.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The effects of antihypertensive agents on the frequencies of reported fainting, dizziness, losses of consciousness, and bone fractures were studied in a large, ambulatory elderly population. The frequencies of these symptoms were compared for subjects who used one or more of nine different antihypertensive agents and for subjects who were not using these medications and who served as a control group. Over 40 per cent of the total population were using at least one of the nine drug groups. Women who used antihypertensive medications reported significantly more fainting (P<0.001), dizziness (P<0.005) and “blacking‐out spells” (P<0.002) but significantly fewer bone fractures (P<0.02) compared with women who were not using such medication in the control group. For men, the use of only one drug group, propranolol, was associated with a significant increase in fainting and dizziness but not blacking‐out spells compared with men in the control. These results suggest that elderly persons may be subject to a variety of central nervous system side effects induced by antihypertensiv

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05142.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Since the progressive nature of Alzheimer's disease and related disorders of later life gradually imposes a series of significant limitations upon the patient, a successful clinical management program rests upon a conceptualization of changes in the patient. Postulating psychologic reactions helps professionals to understand and respond to the patient's needs and feelings at different stages of the disease. The phases discussed here provide the basis for defining treatment goals and management plans, selecting therapeutic strategies, identifying needed resources, and evolving innovative approaches to patient care.

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05143.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The onset of multiple sclerosis (MS) after age 60 is uncommon. The clinical features of three such cases are described. Considerable diagnostic delay was seen in each case as symptoms were initially attributed to other conditions that more commonly afflict the elderly, including atypical facial pain, neuropathy, peripheral and cerebral vascular disease, arthritis, benign prostatic hypertrophy, and ischemic optic neuropathy. Although MS should be considered a diagnosis of exclusion in this age group, cerebral evoked potentials and CSF immunoglobulin studies can increase the diagnostic yield and may be helpful in the appropriate clinical context.

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05144.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Indomethacin, widely prescribed in the elderly, has a potential for affecting concomitant absorption of other drugs by changing gastric emptying time. A study of basal and post‐indomethacin gastric emptying times (GET) in ten patients aged 69–86 (mean age 77) shows no significant change in GET after indomethacin administration. The data suggest that drugs whose potencies can be altered by gastric retention may be taken concomitantly with indometha

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05145.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The authors review recent studies of treatment of hypertension and suggest modified guidelines for the treatment of elderly hypertensive patients. Treatment is recommended for elderly persons with systolic‐diastolic hypertension if the systolic presure is consistently above 160 mm Hg or the diastolic blood pressure is consistently above 100 mm Hg. Treatment of isolated systolic hypertension should not be excessively vigorous, and systolic blood pressure should not be lowered much below 160 mm H

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05146.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The role of receptors in the central nervous system and effects of aging on the four neurotransmitter receptors most often studied in the context of aging—beta‐adrenergic, cholinergic, benzodiazepine, and dopamine—are disc

ISSN:0002-8614    

DOI:10.1111/j.1532-5415.1984.tb05147.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY