ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90084-2

出版商:Wiley    

年代:2005

数据来源: WILEY

摘要:

AbstractThe emergence of resistant strains of bacteria is directly related to the selection of chemotherapeutic agents, and the character of the resistance changes with changes in usefrequency of the various antibiotics. In recent years with increasing use of beta‐lactam antibiotics, there has been an increased incidence of microorganisms that are resistant by virtue of their ability to produce beta‐lactamase enzymes which destroy the beta‐lactam antibiotics. The development of beta‐lactamase inhibitors which may be used in combination with the beta‐lactam antibiotics has been a significant advance for the therapy of gynecologic infections in South America.

ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90085-4

出版商:Wiley    

年代:2005

数据来源: WILEY

摘要:

AbstractSusceptibility of anaerobic clinical isolates from the United States, Canada, and Germany to sulbactam/ampicillin (1 + 2) (SBT/ AMP), ampicillin alone (AMP), and cefoxitin (CFX) was determined with a standard agar dilution test. The isolates included 192 strains of Bacteroides fragilis, 132 strains of other Bacteroides spp., and 19 strains of Clostridium spp. Against all species tested, SBT/ AMP was more active than AMP or CFX Results obtained by a new model of associative susceptibility testing indicated that susceptibility testing of single pathogens from polymicrobial infections is not necessarily reflective of the susceptibility of the pathogens at the site of infection. The results suggest that sulbactam is effective in associations of pathogens producing beta‐lactamases of Richmond‐Sykes types II–V and beta‐lactamases of anaerobic bacteria.

ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90086-6

出版商:Wiley    

年代:2017

数据来源: WILEY

摘要:

AbstractAcute pelvic inflammatory disease is associated with significant adverse reproductive sequelae. To prevent these serious sequelae, treatment regimens must cover the major etiologic agents which are Neisseria gonorrhoeae, Chlamydia trachomatis, and mixed anaerobic‐aerobic bacteria. This report concerns the prospective evaluation of the efficacy of the combination of sulbactam with ampicillin in patients hospitalized with acute pelvic inflammatory disease. Clinical cure was noted in 33 (94%) of 35 patients and post‐treatment cultures demonstrated eradication of N. gonorrhoeae and C. trachomatis in all cases.

ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90087-8

出版商:Wiley    

年代:2005

数据来源: WILEY

摘要:

AbstractIn an open, randomized clinical study, the safety and efficacy of sulbactam/ampicillin was compared to that of cefotetan in 95 hospital patients with gynecologic or obstetric infections. Sulbactam/ampicillin (1 g:2 g), was administered intravenously every 8 h to 46 patients, and cefotetan (2 g) was administered intravenously every 12 h to 49 patients. All 23 patients with obstetric infections and 18 of the 23 patients with gynecologic infections treated with sulbactam/ampicillin were evaluated as cured. All 21 patients with obstetric infections and 23 of the 28 patients with gynecologic infections treated with cefotetan were evaluated as cured. No side effects requiring discontinuation of therapy or reduction of the dose administered, were observed.

ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90088-X

出版商:Wiley    

年代:2005

数据来源: WILEY

摘要:

AbstractIn a prospective, randomized, open trial, efficacy of one dose of sulbactam/ampicillin (1 g:2 g) was compared to three doses of mezlocillin/oxacillin (2 g:1 g), starting with induction of anesthesia in 80 breast surgery patients with an increased risk of postoperative infection. No infections at the site of operation were seen in either group. Fever due to postoperative pulmonary complications occurred in one patient in the sulbactam/ ampicillin group. The only side effect was a moderate exanthema observed in one patient in the mezlocillin/oxacillin group. In this study of the prophylaxis of patients with an increased risk of postoperative infections having the potential to jeopardize the results of surgery, a single dose of sulbactam/ampicillin was as effective as a short term course of three doses of mezlocillin/oxacillin.

ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90089-1

出版商:Wiley    

年代:2005

数据来源: WILEY

摘要:

AbstractThirty‐six hospitalized patients, 18 in each of two groups, with postpartum upper genital tract infection were enrolled in a randomized, prospective study comparing treatment with sulbactam/ampicillin, to treatment with clindamycin/gentamicin. One (5.5%) clinical failure was reported in each group. Side effects were minimal in both groups and did not warrant discontinuation of treatment. The in vitro activity of ampicillin versus sulbactam/ampicillin (1: 2) was evaluated and these data were compared with data from other drugs commonly used for aerobic and anaerobic infections. Sulbactam eliminated resistance to ampicillin in all anaerobic and most aerobic isolates.

ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90090-8

出版商:Wiley    

年代:2005

数据来源: WILEY

摘要:

AbstractThe combination of sulbactam/ampicillin was compared to cefoxitin for the treatment of acute salpingitis in 40 women divided into two groups of 20 women each. There were 11 patients in each group who were given doxycycline because of evidence of chlamydial infection. All patients were diagnosed by laparoscopic examination and evaluated by the same procedure 7–12 weeks later. At the second laparoscopy, only 1 of the 20 patients (5%) treated with sulbactam/ampicillin had severe adhesions, while 6 of the 20 patients (40%) treated with cefoxitin had severe adhesions. Tubal patency was without obstruction in 14 patients (70%) given the combination treatment and in 12 patients (60%) given cefoxitin. Side effects were essentially absent in both groups.

ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90091-X

出版商:Wiley    

年代:2005

数据来源: WILEY

ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90092-1

出版商:Wiley    

年代:2005

数据来源: WILEY

ISSN:0020-6695    

DOI:10.1016/0020-7292(89)90093-3

出版商:Wiley    

年代:2005

数据来源: WILEY