摘要:

SummaryThirteen variables used in the course of characterization of G6PD variants from forty‐one individuals have been submitted to multivariate factorial and cluster analysis. Because of the diagrammatic representation of the analysis, two main findings were made possible. Firstly, the three‐dimensional plot of the experimental data gives the advantage of a model of classification which is closely related to the ethnogeographical origin of the subjects, and to the clinical and haematological incidence of the G6PD variants. Secondly, cluster analysis visualizes the distance between the G6PDs examined. In this respect, it was determined that three local original variants associated with acute haemolytic anaemia showed a close relationship and belonged to the same cluster (Gd(—) Toulouse, Gd(—) Muret and Gd(—) Colomiers). Conversely, two non‐haemolytic variants (G6PD Luz Saint Sauveur and Lozère) were found to be linked in another remote cluster. The procedure developed in this work promotes a new approach to G6PD characteristics in human gen

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01670.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SummaryThe frequency of inherited variations in thermostability was investigated in a series of seven enzymes in a Japanese population. Among a total of 5930 determinations, nine variants were encountered. In each instance one parent exhibited a similar finding. It is suggested that this procedure should detect a high proportion of the variants of these enzymes characterized by amino acid substitutions not altering molecular charge. Failure to detect more such thermostability variants is interpreted to mean that electrophoresis not only detects amino acid substitutions altering molecular charge but also a considerable proportion of those that do not alter charge.

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01671.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SummaryThe successful application of a triple staining technique incorporating quinacrine mustard fluorescence, lacto‐propionic orcein staining and C‐banding to metaphase II cells in the human male is described. This procedure overcomes the major technical difficulties associated with the analysis of these cells, enables unambiguous chromosome counts to be made and allows the majority of cells to be karyotyped. Preliminary results on two hundred cells from six men with apparently normal karyotypes are presen

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01672.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SummaryAn antigen expressed by most human cells, but not erythrocytes, has been defined by a murine monoclonal antibody, TRA‐2–10. This antigen is expressed on the surface of human‐mouse somatic cell hybrids, and segregation analysis indicates that it is controlled by a gene located on human chromosome 1. From lysates of most human cells, surface‐labelled with125I, TRA‐2–10 immunoprecipitates two polypeptides with molecular weights in the range of about 55000 to 73000 depending upon the cell line. Since the TRA‐2–10 polypeptides from a fibroblast cell strain and a hepatoma cell line from one individual differ, we conclude that the observed difference in molecular weight has an ep

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01673.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SummaryThe gene coding for the GM2activator protein has been mapped to human chromosome 5, using an enzyme‐linked immunoadsorbant assay (ELISA) to identify the human protein in human‐mouse somatic cell hybr

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01674.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Summary1. Data on microgeographic population structure on four neighbouring villages of Sardinia island (Italy) are presented and discussed.2. Two villages are located in the lowlands where malaria fromPlasmodium falciparumwas endemic until the eradication of paludism. The other two villages are located in the highlands and they were malaria‐free because of the altitude.3. Census data, inbreeding, migration matrices and surname distributions have been collected. The genetic differentiation of the four villages, tested for 31 genetic polymorphisms (106 alleles), is only in part compatible with migration rates inferred from demographic data.4. The possible adaptive nature of some genetic markers with respect to malarial resistance is discussed. Ambiguous results from population genetics quantitative methods do not support definite answer

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01675.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SummaryThe incidence of twins in Fiji has been investigated using birth registrations for the years 1976–81. The twinning rate for the indigenous Fijians is found to be 9–4 per 1000 live maternities, (based on 407 sets of twins), and for Indians, descendants of immigrants who began to arrive in Fiji in 1879, 6·2 per 1000 (based on 350 twins). After standardizing for maternal age, the difference between the two ethnic groups decreases slightly, but the Fijian rate remains almost 40% above that of the Indians. This difference is consistent over the 6 years of the study, is found for mothers of all age groups under 40 and at all levels of parity. An analysis of hospital records in Fiji produces higher twinning rates for both Fijians and Indians, but a similar difference is found between the two ethnic groups. Although the twinning rate for Fijians is lower than that reported for other Melanesian people, it is well above reliable rates found for Mongoloid races from whom the Fijian is descended. The sparse information on twinning rates among Polynesians suggests rates not dissimilar from Melanesians, so that no support for the hypothesis of low twinning rates in the Pacific is evident. The twinning rate for Indians in Fiji is lower than rates reported from the Indian subconti

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01676.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SummaryA unified methodology is presented for the analysis of intraclass correlation in two or more samples, with emphasis on application to family studies. The methodology provides point and interval estimates of a common intraclass correlation in data having either fixed or variable class sizes. Tests of homogeneity for intraclass correlation coefficients are also discussed.

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01677.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01678.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1985.tb01679.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY