ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01973.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

SUMMARYThe results are recorded of tests for the X‐linked red cell antigen Xgaon families with glucose‐6‐phosphate dehydrogenase deficient members. The families live in Israel and belong to Kurdish, Iraqi, Yemenite, Sefardic and Ashkenazy Communities.Linkage between Xg and g‐6‐pd is established at the 1 in 100 level of probability, and an estimate of the recombination frequency is 0–273 + 0–072.Some of the families also have colour vision abnormalities but the information is not enough to allow an estimate of the recombination fraction between Xg and c.v. to be made. However, the results strongly suggest that the locus for c.v. is further away from Xg than is g‐6‐pd: consequently the probable order on theXchromosome of these three loci is Xg … g‐6‐pd … c.v.We wish to express our gratitude to all the doctors who collaborated with us by providing some of their material. Special thanks are due to Mrs Judith Offer (Hakfar Hayarok), Dr Rina Schmidt and Dr G. Kende (Government Hospital, Tel‐Hashomer, Israel) for their great part in collecting the samples of blood; and to Prof. E. Auerbach and Dr Edith Nelken, of the Vision Research Laboratory, Hadassah Medical School, Jerusalem, who made detailed colour vision tests in one of our families.We are greatly indebted to Dr J. D. Mann of the Butterworth Hospital, Grand Rapids, and to Dr Amos Cahan of Knickerbocker Biologicals, New York, for generous supplies of the most precious anti‐Xgaplasma. The work has been supported in part by Grant A‐2740‐Hema. from the U.S. Public Health Service, and R/00014 f

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01974.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

SUMMARYA family is described containing six deaf‐mute males in four different sibships, showing maternal transmission. Although sex‐limitation cannot be excluded, it is suggested that the disease is due to a sex‐linked recessive

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01975.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01976.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

SUMMARY1Various glucose‐6‐phosphate dehydrogenase‐deficient pedigrees from the literature violating classical patterns of sex‐linked inheritance are reviewed and discussed.2It is suggested that anomalous phenotypes observed in these families may be the result of epistatic reactions between the effects of abnormal sex‐linked genes or gene and an autos

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01977.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01978.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

SUMMARY1The incidence of abnormal haemoglobin genes has been investigated in various populations living in the Greek mainland, Crete and Rhodes.2A previous report of high sickling frequencies in the Chalkidhiki peninsula was confirmed, and the incidence of thalassaemia was found to be low in this region. Relatively low sickling frequencies were recorded in Atalanti in Central Greece and Karditsa in Thessaly, and no sickling was present in samples from Crete and Rhodes.3High β‐thalassaemia frequencies (above 20%) were found in villages in the island of Rhodes, and moderate frequencies (4–7‐9‐8%) in Crete and the Greek mainland towns sampled.4The low incidence of haemoglobin H inclusion bodies observed confirms previous findings that detectable α‐thalassaemia is much less common than β‐thalassaemia in Greece.5In regions where the sickle‐cell gene frequency is high the frequency of thalassaemia is low, and vice versa.6High frequencies of abnormal haemoglobins are found only in regions that were formerly intensely malarious.We are indebted to many Greek physicians for friendly co‐operation and helpful discussion, in particular Dr Limberis, Prof. K. B. Choremis and Dr Ph. Fessas, Athens, and Dr G. Kypriotis, Rhodes. Dr A. U. Smith and Mrs N. A. Barnicot gave valuable help with the haematological investigations. We are also indebted to Prof. L. S. Penrose, Dr E.R.Huehns, Mrs Maynard Smith and Mr Norman Dance for their help.The work was supported by the Section on Geographic Medicine and Genetics, National Institute of Arthritis and Metabolic Diseases,

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01979.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

SUMMARY1Erythrocyte glucose‐6‐phosphate dehydrogenase has been measured on samples from 665 males from different parts of Greece.2High proportions of enzyme‐deficient subjects were found in some regions, notably the Chalkidhiki peninsula and the island of Rhodes.3The incidence of enzyme deficiency in different populations shows a positive correlation with the incidence of abnormal haemoglobin genes, as would be expected if all the genes are favoured by malarial selection.We are indebted to various Greek colleagues who facilitated the collection of blood or providec helpful discussion, including Prof. G. A. Deliyannis and Dr A. Ballas, Salonika, Dr Limberis and Prof. K. B. Choremis, Athens, and Dr G. Kypriotis, Rhodes. The work was supported by the Section on Geographic Medicine and Genetics, National Institute of Arthritis and Metabolic Diseases, Bethesda, Mar

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01980.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

SUMMARYFurther evidence for genetical linkage between thenail‐patellaandABOloci has been found in a New Zealand family.I wish to thank Sir Charles Hercus for his encouragement and Dr A. C. Begg, Mr J. Case, Dr J. B. Howie and Dr D. H. Sutton for their assistance with radiographs and the blood groups. I am particularly grateful to Dr J. H. Renwick for generous and helpful advice and to members of the family for their co‐operat

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01981.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

SUMMARYMeasurement of height, weight, sitting height, biacromial and bi‐iliac diameters, bicondylar diameters of humerus and femur, upper arm circumference, and four skinfolds have been taken on a pure longitudinal series of 117 children at intervals from 1 month to 7 years, on the mothers of all of them and on the fathers of 57. The father‐son, father‐daughter, mother‐son and mother‐daughter correlation coefficients have been calculated at successive ages of the children.Most of these measurements show a steep rise in parent‐offspring correlation from the order of 0–2 at 1 month to the order of 0–4 at 2 years; from 2 to 7 a very gradual rise continues. Weight is an exception, the correlation being highest at 1 month, lowest at 9 months and subsequently rising. The parent‐offspring correlation for skinfolds from 3 to 7 years is only about 0–1, which does not differ significantly from zero.The mother‐daughter correlations for supine length in this age range are significantly above the mother‐son correlations. The same may also be true for weight after age 1, though the statistical significance is not fully established. In bi‐iliac and biacromial diameters no such sex difference occurs. The father‐son coefficient is greater than the father‐daughter coefficient for supine length, though not to a significant degree. The father‐son coefficient for biacromial diameter from 4 to 7 years is significantly above the father‐daughter coefficient.The conclusion is drawn that there are sex‐controlled genes affecting physique operating even before puberty. As there are usually supposed to be no mother‐daughter, mother‐son, etc., correlation differences in adulthood, the question is raised as to when and how these differences may be eliminated from 7 to 17 years. The published adult figures are also reexamined, with the conclusion that the supposed equality of the four parent‐child coefficients is much less securely based on evidence than is generally thought.There is a statistically significant correlation between skeletal maturity as assessed from wrist X‐rays at ages 3 and 5 of sons and the height of their mothers. Thus tall mothers have advanced sons; but they do not have advanced daughters. Similarly tall fathers have somewhat advanced daughters, but not sons. The cause of these correlations is not yet clear; in the adult there is no positive correlation between

ISSN:0003-4800    

DOI:10.1111/j.1469-1809.1963.tb01982.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY