| 1. |
Editorial Comment |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 1-3
Preview
|
PDF (228KB)
|
|
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05757.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
| 2. |
The Metabolism of Alcohol: A Seminar |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 5-5
Frank A. Seixas,
Preview
|
PDF (76KB)
|
|
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05758.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
| 3. |
Microsomal Ethanol Oxidizing System (MEOS): Current Status of Its Characterization and Its Role |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 7-15
Rolf Teschke,
Shohei Matsuzaki,
Kunihiko Ohnishi,
Leonore M. DeCarli,
Charles S. Lieber,
Preview
|
PDF (744KB)
|
|
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05759.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
| 4. |
Chronic Ethanol Administration Induces a Form of Cytochrome P‐450 with Specific Spectral and Catalytic Properties |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 17-20
Jean‐Gil Joly,
Jean‐Pierre Villeneuve,
Philippe Mavier,
Preview
|
PDF (309KB)
|
|
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05760.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
| 5. |
ATP Metabolism in an Ethanol‐Induced Fatty Liver |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 21-25
Ellen R. Gordon,
Preview
|
PDF (433KB)
|
|
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05761.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
| 6. |
Factors Contributing to the Adaptive Increase in Ethanol Metabolism due to Chronic Consumption of Ethanol |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 27-31
Arthur I. Cederbaum,
Elisa Dicker,
Charles S. Lieber,
Emanuel Rubin,
Preview
|
PDF (434KB)
|
|
摘要:
SUMMARYChronic ethanol consumption, in a diet which leads to a fatty liver, results in an increase in the rate of ethanol oxidation in isolated rat hepatocytes. The percent increase (30%‐40%) is similar to that previously found in vivo, in the same model system.1,11This increase does not correlate with the activity of alcohol dehydrogenase, which was slightly decreased after chronic ethanol consumption.1,16The increase in ethanol oxidation is not associated with a hypermetabolic state of the liver since oxygen consumption with a variety of substrates was not enhanced after chronic ethanol consumption. Approximately 40%‐50% of this increase persists in the presence of an inhibitor of alcohol dehydrogenase, inhibitors of mitochondrial oxygen consumption and inhibitors of the malate‐aspartate shuttle. The increase persists in the presence of ouabain, dinitrophenol and various shuttle metabolites (in the presence and absence of dinitrophenol). Chronic consumption of ethanol results in hypertrophy of the smooth endoplasmic reticulum and an adaptive increase in the ability of microsomal preparations to oxidize ethanol to acetaldehyde.1,11The fact that part of the increase in ethanol oxidation which occurs after chronic ethanol administration persists in the presence of the various additives discussed above, indicates that pathways that are independent of alcohol dehydrogenase contribute to this metabolic adaptation. These data extend the observation that the metabolic adaptation found after chronic ethanol consumption was not abolished by 2mM pyrazol
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05762.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
| 7. |
The Role of Alcohol Dehydrogenase in Microsomal Ethanol Oxidation and the Adaptive Increase in Ethanol Metabolism due to Chronic Treatment With Ethanol |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 33-38
Ronald G. Thurman.,
H. J. Brentzel,
Preview
|
PDF (418KB)
|
|
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05763.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
| 8. |
The Spontaneously Hypertensive Rat as a Model for Studies on Metabolic Tolerance to Ethanol |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 39-42
Y. Israel,
J. M. Khanna,
H. Kalant,
D. J. Stewart,
J. A. Macdonald,
G. Rachamim,
S. Wahid,
H. Orrego,
Preview
|
PDF (330KB)
|
|
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05764.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
| 9. |
The Rate of Ethanol Metabolism in Isolated Rat Hepatocytes |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 43-47
Kathryn E. Crow,
Neal W. Cornell,
Richard L. Veech,
Preview
|
PDF (416KB)
|
|
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05765.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
| 10. |
Summary of the Discussion |
| |
Alcoholism: Clinical and Experimental Research,
Volume 1,
Issue 1,
1977,
Page 49-50
C. S. Lieber,
Preview
|
PDF (168KB)
|
|
摘要:
SUMMARYThere was general agreement that catalase cannot account for the activity of MEOS and that chronic ethanol feeding results in increased rates of ethanol metabolism. There was disagreement however on the mechanism of the latter effect, with some invoking the ADH pathway exclusively in association with a hypermetabolic state, whereas according to others MEOS plays a significant role in the adaptive increase of ethanol metabolism.
ISSN:0145-6008
DOI:10.1111/j.1530-0277.1977.tb05766.x
出版商:Blackwell Publishing Ltd
年代:1977
数据来源: WILEY
|
首页
Volume 1 issue 1