ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00514.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00515.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00516.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00517.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Drug utilisation research is a multidisciplinary activity which is now seen as a valuable component of quality assurance wherever medicines are used. This article explains what the research involves and outlines its future applications.

ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00518.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The main complication of continuous ambulatory peritoneal dialysis is peritonitis. This paper reviews its causes and treatment.

ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00519.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The recent clinical demand for cefuroxime eye‐drops has given rise to practical difficulties because of the short shelf life recommended by the manufacturer of Zinacef injection, the product used to prepare the eye‐drops. The purpose of this investigation was to determine the stability of various formulations of cefuroxime sodium eye‐drops by high pressure liquid chromatography.The results showed that buffering the solution in the pH range 6.0 to 7.3 has little effect on the shelf life when compared with a simple aqueous solution of 5 per cent cefuroxime, which retains satisfactory potency for 21 days in a refrigerator at 2°C during simulated patient usage. Although stable for only 24 hours at room temperature, negligible loss of potency is observed after storing the eye‐drops for 12 months at ‐30°C. Frozen solutions should be defrosted at room temperature and shaken thoroughly to redisperse the cefuroxime evenly throughout the solution. Thawed solutions are stable in the refrigerator for a further 21 days at 2°C or for 14 days at 8°C.As temperatures up to 8°C are often recorded with domestic refrigerators, a 14 day shelf life is recommended in th

ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00520.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

An audit ofPneumocystis carinüpneumonia prophylaxis used in HIV‐infected patients within Bloomsbury health authority in 1989 was carried out. A total of 134 patients who were prescribed 167 courses of PCP prophylaxis, with a variety of different regimens, was included in the study. Fifty three patients were prescribed 60 courses of primary prophylaxis, 55 of which were given with concurrent zidovudine. Eighty two patients were prescribed 107 courses of secondary prophylaxis, 96 after one episode of PCP and 11 after two episodes.Patients given primary prophylaxis, together with zidovudine, had a lower incidence of PCP than patients receiving no treatment. With secondary prophylaxis, a higher rate of relapse was seen with nebulised pentamidine than with co‐trimoxazole (16 per cent compared with 4.5 per cent). The incidence of adverse effects with co‐trimoxazole was higher in secondary than in primary prophylaxis. Compliance with nebulised pentamidine therapy was poor. Compliance with oral therapy was not mon

ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00521.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The ability of three insulated coolboxes recommended for vaccine transport to maintain vaccines below 10°C was evaluated. Studies using coolboxes and ice packs both precooled to 5°C indicated that the Giostyle Portable and Vaccine Carrier coolboxes were able to maintain loads below 10°C for periods up to two to four hours. Ice packs precooled to ‐20°C caused freezing of some vaccines in a load and should only be used if sufficient insulation is provided to separate the vaccines from the ice pack surfaces. The smaller Mailbox, with a lid‐positioned ice pack precooled to ‐20°C, maintained loads below 10°C for up t

ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00522.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

To limit the cost of increasing intravenous nitrate usage at the General Infirmary at Leeds, intravenous glyceryl trinitrate was promoted as the drug of choice. The methods used to introduce this prescribing strategy are described. The resulting savings were £24,000 and £21,000 during the financial years 1988‐1989 and 1989‐1990 respect

ISSN:0961-7671    

DOI:10.1111/j.2042-7174.1991.tb00523.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY