摘要:

AbstractMicrofluidic chip offers a promising platform for chemical or biological analysis on the basis of flexible integration of various functional operation units. This article provides an overview of the recent achievements of microfluidic chip and its applications based on the works mainly carried out in the authors' lab, especially for the purpose of constructing analytical laboratory on a microfluidic chip. Different operation units and some representative applications in molecules, cell and organism analysis are described.

ISSN:0009-4536    

DOI:10.1002/jccs.200900001

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY

摘要:

AbstractThe single‐crystal‐to‐single‐crystal (SCSC)EŕZphotoisomerization of TA in the supramolecular solid CECR‐[Zn(TA)2(bpy)]·H2O (CECR =C‐ethylcalixresorcinarene, HTA = tiglic acid, and bpy = 2,2′‐bipyridine, is induced by 458 nm light, indicating a red‐shift of the photo‐active wavelength on introduction of the aromatic bpy ligand compared with the previously studied reaction of CECR‐[Zn(TA)2(H2O)2] 4H2O. Theoretical calculations show that the initial excitation involves the bipyridyl ligand, which acts as an intramolecular photosensitizer for the isomerization process. The reaction is topotactic and illustrated

ISSN:0009-4536    

DOI:10.1002/jccs.200900002

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY

摘要:

AbstractDFT/B3LYP calculations are able to reproduce the magnetic behaviour of dinuclear complexes of CuIIwithin the framework of the Heisenberg Hamiltonian. The trinuclear complexes recently characterized by Glaser et al from trinucleating Robson‐type ligands provide an opportunity to extend the application of the broken symmetry formalism to a nonsymmetric CuIICuIICuIIframework. At variance with the tentative fit deduced from experiment, the calculations suggest that the coupling along the three magnetic centers could be wea

ISSN:0009-4536    

DOI:10.1002/jccs.200900003

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY

摘要:

AbstractTreatment of (NH4)[Au(D‐Hpen‐S)2](D‐H2pen = D‐penicillamine) with CoCl2·6H2O in an acetate buffer solution, followed by air oxidation, gave neutral AuICoIIIand anionic AuI3CoIII2polynuclear complexes, [Au3Co3(D‐pen‐N,O,S)6]([1]) and [Au3Co2(D‐pen‐N,S)6]3−([2]3−), which were separated by anion‐exchange column chromatography. Complexes [1] and [2]3−each formed a single isomer, and their structures were determined by single‐crystal X‐ray crystallography. In [1], each of three [Au(D‐pen‐S)2]3−metalloligands coordinates to two CoIIIions in a bis‐tridentate‐N,O,Smode to form a cyclic AuI3CoIII3hexanuclear structure, in which three [Co(D‐pen‐N,O,S)2]−octahedral units and six bridging S atoms adopttrans(O) geometrical andRchiral configurations, respectively. In [2]3−, each of three [Au(D‐pen‐S)2]3−metalloligands coordinates to two CoIIIions in a bis‐bidentate‐N,Smode to form a AuI3CoIII2pentanuclear structure, in which two [Co(D‐pen‐N,S)3]3−units and six

ISSN:0009-4536    

DOI:10.1002/jccs.200900004

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY

摘要:

AbstractA set of novel imidazolidinedione derivatives were synthesized and evaluated as potential antidiabetic agents. Imidazolidinedione scaffold‐based molecules were synthesized and validated on a mice hyperglycemia model caused by alloxan. As a result, three of them showed antihyperglycemic activities. This research provides useful clues for further design and discovery of antidiabetic agent

ISSN:0009-4536    

DOI:10.1002/jccs.200900005

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY

摘要:

AbstractGlycinium chlorochromate (GCC) supported onto silica gel was used as an effective oxidizing agent for the aromatization of 1,4‐dihydropyridines to corresponding pyridin

ISSN:0009-4536    

DOI:10.1002/jccs.200900006

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY

摘要:

AbstractOxidation of 1,3,5‐trisubstituted 4,5‐dihydro‐1H‐pyrazoles to the corresponding pyrazoles has been achieved by utilizing tetrabromine‐1,3,5,7‐tetrazatricyclo[3.3.1.13,7]decane complex, Br4‐TATCD, in glacial acetic acid under microwave irradiation and conventional thermal condition at room temperature with exc

ISSN:0009-4536    

DOI:10.1002/jccs.200900007

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY

摘要:

AbstractA short, efficient synthesis of 2‐methoxy‐6‐alkyl‐1,4‐benzoquinones is described. Ultrasound‐assisted Wittig reaction of alkyltriphenyl phosphonium bromides witho‐vanillin in basic aqueous conditions followed by reduction with Na/n‐BuOH gave 2‐methoxy‐6‐alkylphenols. Oxidation of 2‐methoxy‐6‐alkylphenols with Fremy's salt p

ISSN:0009-4536    

DOI:10.1002/jccs.200900008

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY

摘要:

AbstractA novel type of phosphoramidate derivatives of 2‐arylquinolone were synthesized through a facile phosphorylated reaction for the first time. The structure of these compounds was elucidated by IR, HR MS, NMR and X‐ray. Synthesis and structural characterization of the titled compounds was discus

ISSN:0009-4536    

DOI:10.1002/jccs.200900009

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY

摘要:

AbstractA 3D‐QSAR study of celebrex‐based compounds of PDK1 inhibitors using comparative molecular field analysis (CoMFA) was carried out. The structures of the compounds were obtained using quantum chemistry calculation. CoMFA calculations for a number of grouped subsets of compounds gave q2values of correlation in the range from 0 to 0.8. The low q2values should be mainly due to the narrow span of biological activity. Calculations for several subsets of 11–13 compounds gave high q2values, with 0.5–0.8. Factors affecting the results of the calculations are discussed. Calculated results with high q2values suggest that further chemical modifications of the compounds could lead to enhanced activity and could be an aid in the design of celebrex‐based can

ISSN:0009-4536    

DOI:10.1002/jccs.200900010

出版商:WILEY‐VCH Verlag    

年代:2009

数据来源: WILEY