摘要:

The effects of repeated treatment with electroconvulsive shock (ECS) and imipramine on [3H]8-OH-DPAT binding to serotonin1A (5-HT1A) receptors in the rat brain were studied by quantitative autoradiographic analysis. A large number of binding sites for [3H]8-OH-DPAT were observed in the hippocampus, especially the dentate gyrus, CA1+CA2 field, dorsal raphe nucleus and septum. Repeated treatment with ECS, but not repeated imipramine treatment, significantly increased [3H]8-OH-DPAT binding sites in the dentate gyrus. These results suggest that the increase in [3H]8-OH-DPAT binding sites in the dentate gyrus may be important in ECS therapy for depressive illness.

ISSN:0302-282X    

DOI:10.1159/000119413

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

This study was carried out to investigate the immune function in obsessive-compulsive disorder (OCD). Plasma levels of interleukin (IL)-1β, IL-6, soluble IL-6 receptor (sIL-6R), sIL-2R, and transferrin receptor (TfR), and baseline plasma cortisol levels were measured in 19 OCD patients and 19 normal controls. No significant differences in any of the above immune variables were found between subjects with OCD and normal controls. There was a significant positive correlation between IL·6 or sIL·6R concentrations and severity of compulsive – but not obsessive – symptoms. In subjects with OCD, there was a significant negative relationship between sIL-2R concentrations and plasma cortisol values. In subjects with OCD and in the study group as a whole, there were significant positive relationships between sIL-2R and TfR concentr

ISSN:0302-282X    

DOI:10.1159/000119136

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

To evaluate seasonal influences on the dexamethasone suppression test (DST), cortisol and melatonin responses to dexamethasone were assessed in drug-treated chronic schizophrenics and in drug-free healthy volunteers in different seasons of the year, according to a longitudinal study design. In schizophrenic patients, there was a greater rate of cortisol non-suppression to DST in February as compared to November and May (χ2 = 4.5, p = 0.03) with no significant differences in pre- and post-dexamethasone plasma cortisol levels. In healthy volunteers, in contrast, no seasonal variation in DST results was observed. Moreover, dexamethasone administration did not significantly affect morning plasma melatonin levels in either patients or healthy controls. These findings suggest that seasonality may be of critical importance in evaluating DST results in schizophrenic patients, but not in healthy subjects

ISSN:0302-282X    

DOI:10.1159/000119137

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

The results of a double-blind, randomized, therapeutical trial with SER282, an antidiencephalon immune serum (Serolab, Lausanne, Switzerland), in 36 women, aged 24-56 years, with primary fibromyalgia are presented. Treatment was ambulatory and consisted of either SER282 (20 mg/ml) or amitryptiline (AMI, 50 mg) or placebo (PL) over an 8-week treatment course. Clinical and sleep EEG polygraphic data were obtained at baseline and after 4 and/or 8 weeks of therapy. Compared to an important PL response and moderate analgesia with AMI, pain and associated symptoms improved moderately with SER282. In contrast, polysomnographic recordings showed that SER282 tended to promote stage 4 sleep, while AMI and PL had few – if any – effect on sleep. These results are discussed together with the clinical characteristics of the patients and the relations between pain, associated symptoms, and sleep parameters in our patient populat

ISSN:0302-282X    

DOI:10.1159/000119138

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Plasma magnesium levels were tested in a group of 155 psychiatric in-patients with a variety of diagnoses and were correlated with the severity of their symptoms. We hypothesized that lower Mg levels would correlate with a higher degree of anxiety, tiredness and other symptoms characteristic of Mg deficiency. No such correlations were observed. However, Mg levels varied widely, with 22.4% below, and 10.4% above the normal range. There was a strong association for more disturbed and excitable patients to have abnormal (either high or low) levels. We speculate that more disturbed patients might have some abnormality of Mg metabolism with possible therapeutic implications.

ISSN:0302-282X    

DOI:10.1159/000119139

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

A principal components analysis was carried out on subjective data obtained from the sleep questionnaire systematically used in our laboratory on the morning following a polysomnographic recording. This technique, based on 70 healthy subjects, revealed three principal axes which explore the questionnaire. The first axis reflects the subjective evaluation of the quality of sleep. The second underlines the importance of dreams and of the brief waking periods which immediately follow. Finally, the third axis brings out the subjective assessment of sleep efficiency. The third axis was the most ambiguous and the only one to show a gender difference. Women tend to better estimate general sleep events, while men tend to evaluate better the more circumstantial events. Finally, given the results, it would be interesting to apply a similar analysis to populations presenting sleep disorders in order to establish the presence of an eventual pattern specific to the disorder.

ISSN:0302-282X    

DOI:10.1159/000119140

出版商:S. Karger AG    

年代:1994

数据来源: Karger

ISSN:0302-282X    

DOI:10.1159/000119141

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Three hundred in- and outpatients suffering from depressive disorder, as diagnosed using DSM-III criteria were treated for 6 weeks under double-blind conditions in a multicenter controlled study of tianeptine vs. amitriptyline. Both groups presented steady improvement of depressive syndrome from day 7 up to the end of the treatment, as shown by all evaluation scales: HDRS, SAD, CGI. Furthermore, anxiety linked to the depressive syndrome decreased equally in both groups, as shown by the HARS measurements. In addition to the improvement of mood, the tianeptine-treated patients presented less somatic complaints and side effects when compared to the reference antidepressant. These results confirm previous findings that tianeptine is an effective antidepressant with a lower side effect profile than amitriptyline.

ISSN:0302-282X    

DOI:10.1159/000119142

出版商:S. Karger AG    

年代:1994

数据来源: Karger

ISSN:0302-282X    

DOI:10.1159/000119143

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Cardiovascular measurements were used as indicators of autonomic arousal during an orthostatic challenge test without medication and after a test dose of 150 mg perazine in 20 acute schizophrenic patients. Unmedicated schizophrenics showed elevated heart rates and elevated systolic and diastolic blood pressure in comparison to healthy volunteers. After a test dose of 150 mg perazine, responders (using BPRS outcome criteria after 23 days) showed a pronounced orthostatic heart rate reaction in comparison to nonresponders. Results are discussed in relation to arousal theories and central dopaminergic activity in schizophrenia.

ISSN:0302-282X    

DOI:10.1159/000119144

出版商:S. Karger AG    

年代:1994

数据来源: Karger