摘要:

A 75‐year‐old man developed an eczematous eruption on the face and dorsal aspects of the hands one July after 3 weeks' treatment with quinine, 0.25 g nightly, for nocturnal leg cramps. The photoreaction cleared within a week of quinine being stopped. UVA and UVB erythema threshold determinations, after the acute episode had subsided, were normal. A photopatch test was positive for irradiated quinine down to a concentration of 0.01% and for unirradiated quinine to 0.5%. The test with the isomer quinidine was positive only when irradiated, down to a concentration of 0.01%. Preirradiated samples of quinine and quinidine were negative. Whereas in contact allergy quinine and quinidine usually do not cross‐react, after systemic photosensitization, the 2 isomers probably form a common photoproduct, accounting for the cross‐re

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00859.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We report the results of sacrified photopatch testing in 3 patients with photosensitivity to lomefloxacin, a new quinolone: antibacterial agent introduced onto the Japanese market in April 1990. The patients developed pruritic eczematous lesions on sun‐exposed areas 5 days to 3 weeks after they had started taking lomefloxacin. 2 cases reacted positively to lomefloxacin on scarified photopatch testing down to 0.1% pet., arid 1 patient down to 10% pet One of them also showed positive reactions on conventional photopatch testing; Scarified photopatch testing with 7 other pyridone carbonate derivatives in 2 of the 3 cases, however, did not show any positive reactions patch and scarified patch testing were negative in all patients. The clinical course, clinical and histological findings and results of skin tests in these patients suggest that photoallergic mechanisms arc involved. This is the 1st report of positive reactions on scarified photopatch testing, which appears to be a useful method of detecting the causative drug in drug‐induced photosensitiv

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00860.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The purpose of the study was to evaluate a sell‐administered questionnaire on hand dermatitis than was developed to identify persons with hand dermatitis in epidemiological studies. A total of 109 nurses were subject to dermatological examination of the hands within 1 month of returning the questionnaire. 2 types of questionnaire diagnoses were made: a ‘symptom‐bused’ diagnosis and a ‘self‐reported diagnosis’. These were compared to the medical diagnosis of hand dermatitis. The prevalence of hand dermatitis in the 12 months before the study, based on the medical diagnosis, was 18.3%. The prevalence according to the symptom‐based diagnosis and the self‐reported diagnosis was 47.7% and 17.4%. respectively. The sensitivity and specificity of the symptom‐based diagnosis were 100% and 64%, respectively. It is concluded that the symptom‐based diagnosis can be used as screening instrument for the detection of cases in large study populations, if followed by dermatological examination of persons with a positive diagnosis. The sensitivity and specificity of the self‐reported diagnosis were 65% and 93%, respectively. It is concluded that the self‐reported diagnosis can be used to obtain a rough estimate of the prevalence, although comparison of prevalence figures between study populations may be distorted due to a difference in reporting of hand dermatitis. The results of the study illustrate the size of the differences in prevalence estimates that may arise as a result of differences in the definition and method of d

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00861.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We have studied a group of 104 patients with pompholyx, to investigate the relationship between allergological factors and its etiopathogenesis. The following examinations were performed; blood sampling (routine tests and IgE levels), allergological tests (patch, prick, intradermal, and oral provovation tests with nickel sulphate), skin biopsy to exclude pemphigus vulgaris or bullous pemphigoid. An accurate history of familial and personal allergic diathesis was enquired for and various possible aggravating factors (season, microclimate, perspiration and emotional stress) were considered. The results were age and sex‐matched with a healthy control group (208 subjects). We found familial and personal atopic diathesis in 50% of patient wersus 11.5% of controls (p<0.001); 39 patients (37.49%) also had high levels of IgE. Nickel sulphate was the allergen with the highest positivity on patch testing: 20.19% versus 6.25% of the control group (p<0.001). The % of patients allergic to nickel reached 26%. including those (6 patients) reacting to the oral provocation test. Season (43 patients) and hyperhidrosis (38) were the aggravating factors most commonly claimed. We detected no correlation between age, sex grading of pompholyx and the allergolngical parameters investigated. Though several different allergological findings have previously been reported in dyshidrosis their role in its pathogenesis has not yet been fully explained. We think that different haptens or antigens can produce the same clinical and histological picture of pompholyx in predisposed subject

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00862.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The keratinocyte expression of class II MHC antigens HLA‐DR, DP and DQ was studied in 20 long‐lasting allergic patch test reactions and 17 normal allergic patch tests reactions. No significicant difference in the expression of these antigens in the 2 groups was detected. No 1 allergen was responsible for the majority of long‐lasting allergic patch test reactions. The immunological mechanisms which may contribute to long‐lasting allergic patch test reactions are discussed with reference to HLA‐DR Kera

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00863.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Skin blood flow in allergic contact reactions and cross‐sensitivity were evaluated using laser Doppler flowmetry (LDF) to study the dose‐response relationships in phases of induction and challenge in guinea pigs. Guinea pigs were sensitized with different doses of 1‐chioro‐2,4‐dinitrobenzene (DNCB) and challenged with different doses of DNCB and 2,4‐dinitrobenzene sulfonic sodium salt (DNBS). The skin reactions were evaluated by LDF and visual reading score. The results indicated that there were dose‐response relationships between the doses of DNCB and LDF measure‐men is in both phases of induction and challenge, that there was a cross‐reaction between DNCB and DNBS. and that the reactions at 24 h were greater than that at 48 h after removal of the patches. LDF may discriminate between positive patch test reactions and negative or doubtful reactions, but not between weak positive and strong positive reactions. This is because vascular dilatation and increase of flow already reaches a maximum in weak reactions. The more advanced phases are dominated by oedema formation. This is simply the nature of the inflammatory reaction, rather than a methodological error. The important point is that LDF, can separate positive reactions from negative/uncertain reactions. The results indicated that LDF, as a non‐invasive technique, may objectively und quantitatively evaluate the dose‐response relationships of contact sensi

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00864.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

26 different compounds have been investigated experimentally for their sensitizing capacity in guinea pigs. 19 of these occur in propolis as well as in poplar bud exudates, and 14 of them are also found in balsam of Peru. 4 caffeates and benzyl isoferulate were found to be strong Sensitizers. 7 compounds were moderate, and 13 compounds showed only weak sensitizing potency. Methyl cinnamate was negative. Patch tests in 11 propolis‐sensitive patients once more revealed 3‐methyi‐2‐butenyl caffeate and phenylethyl caffeate as the major sensitizers. In addition to the 8 compounds already known to occur in propolis as well as in balsam of Peru, we detected 5 further substances that both materials have in common. Among these, benzyl isoferulate is considered a noteworthy sensitizer. Coniferyl benzoate, which was shown to be a moderate sensitizer, is present in fresh samples of balsam of Peru, while in propolis it has been detected only once so far. The flavonoid aglycones occurring in poplar bud exudates, and hence also in propolis, are weak sensitizers which play only a minor role m propolis hypersens

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00865.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00866.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00867.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1992.tb00868.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY