摘要:

495 patients were standard photopatch tested with Musk Ambrette 5% in petrolatum and in dimethyl phthalate. 4 cases gave positive photopatches: 3 were men and 1 a woman 2 cases, both men, had current or past relevant reactions to Musk Ambrette presented with typical perfume dermatitis. The other 2 cases had positive reactions to Musk Ambrette of uncertain relevance. Photoallergic reaction to Musk Ambrette is a rare event. Only a few relevant reactions will be missed by excluding it from standard phototesting.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04618.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

194 patients were standard photopatch tested with Wastar® as is (coal tar 5%) and 161 patients were photopatched tested with para‐aminobenzoic acid (PABA) 5% in alcohol, potassium dichromate 0.5 in petrolatum, and a mixture of balsams of Peru as is. The photopatches were irradiated with UVA.40 patients (25%) had phototoxic reactions to Waxtar® and 4 of them showed pigmentation after 7 days. Only a few patients had photocontact urticaria. I patient had a late‐reaction to PABA and showed a cross‐reaction to glyceryl PABA but a negative reaction to paraphenylenediamine (PPD) and benzociane 5% in the standard test.No patients had positive photopatch reactions to potassium dichromate when irradiated with UVA.2 patients had phototoxic reactions to balsam of Peru. None had photoallergic reactions.Standard photopatch testing is a time consuming procedure which creates problems both for the staff and for the patients. The yield of unexpected, relevant positive reactions is insignificant.From a cost‐benefit view, photopatch testing is only warranted in cases giving rise to a clinical suspiction of photod

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04619.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The aim of this study was to investigate the sensitizing potential of 12di(meth)acrylates, when tested in the Guinea Pig Maximization Test (GPMT) and Freund's Complete Adjuvant Test (FCAT). In these tests the same (molar) concentration was used for intradermal induction. The results (see table, below) show that dimethacrylates are moderate to strong sensitizers in the guinea pig. In the group of diacrylates, no sensitization to diethylene glycol diacrylate was observed. 1,2‐ethanediol diacrylate and 1,6‐hexanediol diacrylate sensitized a number of animals. The challenge reaction pattern of the FCAT with 1,4‐butanediol diacrylate, neopentane diol diacrylate and 1,5‐pentanediol diacrylate differed from that commonly observed with sensitizers. Positive reactions were seen only to the maximum non‐irritant concentration at 24 h in the challenge at day 21. At 48 h and in the second challenge at day 35, the reactivity had decreased or disappeared. This different reaction pattern makes it difficult to classify these monomers with certainty as sensitizers.In most of the FCATs, a decrease in reactivity in successive challenges was found. Possible explanations for this decrease and for the different challenge reaction patterns of some diacrylates are discussed.The skin irritant capacity of di(meth)acrylates was estimated after one open application. Diacrylates are very strong irritants on guinea pig skin. Dimethacrylates are weak

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04620.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

It is desirable to use more objective methods than visual scoring for the assessment of skin irritancy reactions. The edema, or fluid accumulation in the exposed skin sites, can be accurately measured by a caliper and this alternative method of assessment is evaluated from different aspects. Sodium lauryl sulfate (SLS) and non‐anoic acid in different concentrations were applied daily to human and animal (rabbit and guinea pig) skin, and a dose‐response relationship established. Higher concentrations of the irritants induced an earlier response. With 5% SLS as the test substance and the increase in skin fold thickness as the single parameter of skin irritancy, the guinea pig was found to be less reactive than rabbit and man. Measurement techniques, reproduceability and advantages and disadvantages with different animal models are discus

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04621.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Phytophotodermatitis fromHeracleum laciniatumis described in 2 typical cases. Experimental phytophotodermatitis was produced using homogenates from leaves of the plant and long‐wave ultraviolet light. The homogenates of leaves produced strong phototoxic reactions. The minimal phototoxic erythema dose was determined to be lowest for abdominal and midback skin.The action spectrum forHeracleum Laciniatumhomogenates applied topically was found to be in the range 315–375 nm with peak sensitivity at 330–3

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04622.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

19 photo substances were studied by thin‐layer chromatography (TLC) as fresh solutions, and during storage under various conditions. Chlorhexidine was excluded as it is sparingly soluble and only used in commercial products as a derivative. Trichlorocarbanilide was the only substance shown to be impure from the start. Only benzocaine, buclosamide, chlorhexidine acetate and chlorhexidine gluconate remained unchanged to the naked eye, and in TLC. The other substances were changed in colour and/or in their TLC‐pattern. An extraction method is described which makes it possible to use TLC for the examination of substances in petrolatum preparations. UV‐absorption spectra have also been examined for all the subst

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04623.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

22 patients with dermatitis from propolis were studied. In all the 21 tested subjects the tests with propolis were positive, and in 19 they were also positive to balsam of Peru. The chromatograms of the balsam and propolis show marked similarity and 3 identical peaks could be recognised in both substances. Among the patients sensitive to balsam of Peru and propolis, 12 were tested with some common components; 3 were positive to cinnamyl cinnamate, 2 to vanillin and 1 to benzyl cinnamate. Chromatograms of the 3 propolis samples from the Warsaw region were very similar, but not identical. Some of the patients were tested with 35 essential oils and eugenol. Sensitivity to clove oil was common.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04624.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Dermatitis in 8 female nursery workers handlingAlstroemeria ligtucultivars has been proven in 6 cases to be of allergic origin. Epicutaneous tests with cut flower extracts as well as with the isolated and purified sensitizer were positive. Successful animal experiments corroborated the sensitising capacity ofAlstroemeriacultivars. The responsible but unstable contact allergen. α‐methylene‐γ‐butyrolactone (tulipalin A), was found in short ether extracts of flower petals in concentrations up to 18%. Due to its instability, subsequent extractions were performed with methanol, yielding the sensitising constituent after purification in the glucosidic form (tuliposide A). This could be stored at room temperature for longer periods without loss of activity. Tuliposide A was determined in specimens ofAlstroemeria ligtucultivars of 14 different origins of various colours: its content varied between 1 and 2%. Direct testing of the plant material in human patients carries the risk of false positive reactions and active sensitization, as the threshold for both forms of the allergen is very high. Only a concentration of 0.01% can be consider

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04625.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

As report of contact dermatitis in humans due to acrylate compounds have increased considerably in recent years, it was decided in investigate the ability of these chemicals to evoke contact sensitivity skin reactions in guinea pigs. 21 different acrylate and methacrylate compounds were scanned for their ability to induce contact sensitivity, using 5 different sensitization protocols. Contact reaction of varying intensities were produced to all the mono‐, di‐ and triacrylates tested. However, it was not possible to sensitize guinea pigs to any methacrylates. It would appear that guinea pigs cannot be contact sensitized to acrylate chemicals that are substituted on carbo

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04626.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A case of allergic contact dermatitis caused by pyridoxine 3,4‐dioctanoate and hinokitiol is reported. The patient was also sensitized to pyridoxine hydrochlorid

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1983.tb04627.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY