摘要:

After classification and identification of the plant, the alcoholic extract ofCachrys libanotisL. was analysed in order to identify the phototoxic agents. The substances responsible for photodermatitis were found to be 4 furocoumarins, of which 3 have been clearly identified, namely 5‐methoxy‐, 8‐methoxy‐and 5,8‐dmiethoxypsoralen. The structure of a 4th compound was not completel

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01620.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Thimerosal sensitivity is Extremely common in Austria, being surpassed asa contact allergen only by nickel, This high incidence is still rising and is probably due to the Frequent vaccinations which are performed in Austria Most, or the patch‐test‐positive patients had recently been immunized with thimerosal‐containing vaccines, and no other obvious sources of exposure to thimerosal could be found, On retrospective questioning. 48 out of 50 patients had had no problems with their recent immunization; the 2 who reported massive local reactions had received their injections, against the recommendation of Ihe manufacturer. Subcutaneously. In a prospective study. 12 thimerosal‐sensitized persons received their follow‐up immunization at our department, and no side effects occurred. This enables us to conclude that sensitization had occurred through vaccines, but trial those amounts of thimerosal delivered i.m. are not sufficient to elicit clinical symptoms. Patch‐test Positivity to thimerosal thus represents no contra‐indication to i.m immunization with Thimerosal‐cont

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01621.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The nickel contamination of the metallic patch test substance from 3 commercial sources was estimated by atomic absorption spectrophotometry. Contamination was generally greatest in the cobalt patch test substances. To determine whether the levels of contamination encountered were sufficient to produce a false positive patch test, 20 nickel‐sensitive patients were patch tested to various concentrations of free elemental nickel in aqueous solution. The level of nickel contamination was less than that required to produce a false positive patch test in our patients, but was at a level which could produce false positive reactions in subjects highly sensitive to nicke

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01622.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

We assessed the effect of repeated application of cutting oil on 9 guinea pigs' skin by visual scoring and skin water vapour loss measurement. The visual scores (severity score) were significantly higher on skin treated with cutting oil (positive control) compared to untreated skin (negative control). The corresponding mean SVL values were also significantly higher. We also assessed the effect of 2 barrier creams on the 9 guinea pigs' skin treated with cutting oil. The visual scores on skin treated with either barrier cream were significantly higher than positive control skin. The corresponding mean SVL values on skin treated with either barrier cream were also higher (not statistically significant). It appeared that the 2 barrier creams did not confer protection against the irritant effect of the cutting oil. On the contrary, barrier creams appeared to exacerbate the irritant effect of cutting oil.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01623.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Positive patch test reactions to thimerosal 0.1% pet (40/ 690 subjects: 5.8%) were more common in younger age groups, in the allergic contact dermatitis group and in subjects who had used contact lens solutions. In the 40 thimerosal‐positive patients, the minimum eliciting quantity of preservative was evaluated using different test concentrations: 0.05% and 0.01% pet (patch testing) and 1:10,000 in saline (intradermal testing). Cross‐reactions between thimerosal and other mercury Compounds and sensitivity to thiosalicylic acid were also examined. The results of the investigation demonstrate that many of the reaction to 0.1% thimerosal are probably irritant, because only half the subjects studied had positive patch test when allergen concentrations 5 to 10 × lower than that conventionally used for patch testing, were utilized. In these subjects, the average strength of patch test reactions was higher, intradermal testing was more often positive and cross‐reactions between mercurials more frequent. These data indicate that the optimal eliciting patch test concentration for studing thimerosal sensitivity is 0.0

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01624.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Before 1960, eosin sensitivity was not rare and lipstick cheilitis was very common. We report 4 patients soon in 1988 and 1989 who were sensitized to eosin from topical bacteriostatic preparations. All 4 patients had positive patch tests to eosin. The allergen is probably an impurity rather than eosin itself.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01625.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Guinea pigs were sensitized to dinitrochlorobenzene (DNCB) by the intracutaneous route and challenged epicutaneously tin the flanks. The intensity of the allergic contact dermatitis was evaluated by inspection and palpation as well us by wet weight determination. With the purpose of diminishing tissue neuropeptides, and substance P in particular, the animals were treated with capsaicin either between induction and challenge, or before sensitization, In comparison with controls, the contact dermatitis was Enhanced in both groups of animals treated with capsaicin.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01626.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Nickel sulphate is a sensitizer in guinea pigs, but the frequency of sensitization varies from study to study. The dose‐response relationship for NiSO46H2O was evaluated in the guinea pig maximization test in this study, 6 intradermal (0.01%–3.0% aq.) and 6 topical (0.25% 10.0% pet.) concentrations were chosen for induction and NiSO46H2O 1% pet was used for challenge, based on the absence of skin irritation in a pilot study. Blind reading was performed. A logistic dose‐response model was applied to the challenge results. At 48 h, a linear relationship was obtained between the intradermal induction dose (but not topical dose) and the response, resulting in a maximum sensitization rate of 40% after 3% i.d. The reactivity disappeared at re‐challenge I week later. Following a booster closed patch on day 35, using NiSO4pet., the animals were challenged with NiSO42% pet. and statistical analyses of 72‐h readings revealed a non‐linear dose‐response relationship, giving a maximum response Frequency of 40% after initial induction with NiSO4, 3% i.d. a

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01627.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

9 cases of contact sensitivity toDittrichia viscosa, mainly with an airborne pattern, aree described. All patient reacted to the fresh leaf of die plain and to its ethereal extracts at 1 and 0.5% pet., and some of them also to that at 0.1% pet. Positive reactions toFrullania dilatata, Laurus nobilis, some other members of the Composite, and helenin were observed, suggesting the diagnosis of a sesquiterpene‐lactone‐induced allergic contact dermati

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01628.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Patch testing to chlorhexadine is usually performed with chlorhexidine gluconate aq. We report the results of 297 patients, almost all with leg ulcers, concomitantly tested with chlorhexidine acetate 1% aq. and chlorhexidine gluconate 1% aq, 39 patients had positive reactions to one of these compounds or to both, 36 positive reactions to the acetate were found, in contrast to 18 reactions to the gluconate. The reactions were considered relevant in 22 of 39 patients, since these patients had developed an eczema in an area where a chlorhexidine compound was used, and discontinuing the chlorhexidine compound resulted in improvement of the condition In 10 of these 22 patients, the diagnosis would have been missed if the gluconate only had been used for testing, while the acetate failed to diagnose 2 patients. In 109 patients without leg ulcers, inconclusive patch test readings (i.e., irritant reactions or weak positive reactions) were found in 17% with chlorhexidine acetate 1% aq., compared to 5% with chlorhexidine gluconate 1% aq., indicating a high degree of irritant potential of the acetate 1% aq. We consider that some positive reactions are lost if chlorhexidine gluconate 1% aq, only is used for patch testing, but that chlorhexidine acetate 1% aq. On the other hand, is an unacceptably strong irritant. We therefore suggest that further testing with chlorhexidine acetate 1 and 0.5% aq, should be performed, in parallel with chlorhexidine gluconate 1% aq. in order in establish appropriate test concentration, We find that up to 13% of the Sea ulcer patients in this study may be sensitized to chlorhexidine, and we recommend that the indications for the drug in leg ulcer patients should be reconsidered.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1991.tb01629.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY