ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03314.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

We report of a 62‐year‐old male patient with a dull red itchy nodule on the induction area of allergic contact dermatitis to squaric acid dibutylester. Which had been used for the therapy of alopecia universalis. The excised biopsy specimen showed dense infiltration of lymphoid cells in the dermis and subcutaneous tissue, associated with the formation of lymphoid follicles, Immunohistologic analysis of the infiltrates indicated mixed proliferation of T‐ and B‐cells. A biopsy specimen from the challenge area showed spongiosis in the epidermis and lymphoid cell infiltration in the upper dermis, while the infiltrates consisted mainly of T‐cells. The following points are discussed: (i) the lesion had an iatrogenic origin and the causative agent was quite evident: (ii) the route of allergen application was only through the epidermis and not directly in the dermis; (iii) lymphoid cell infiltrates of the induction and challenge areas were

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03315.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

The time course for transepidermal water loss (TEWL) for a period of 3 h after removal of occlusive patch tests with sodium lauryl sulphate (SLS), water and empty chambers was studied in healthy volunteers. Patches were applied to the upper arm for 24 h, TEWL was measured immediately after removal of the patches, and every 30 min up to 3 h. For SLS and water patches, TEWL remained significantly increased for 3 h. as compared to normal adjacent skin, while for empty chamber patches. TEWL was only significantly increased for 30 min. A significant decrease from 0 to 30 min and from 30 to 60 min was observed for all patches, and for water patches, a significant decrease in TEWL was found from 60 to 180 min, while SLS patches remained constant. The prolonged increase in TEWL observed after SLS exposure is a well‐known occurrence. The prolonged increase in TEWL after exposure to water is interpreted as transient damage to the water harrier of the ski

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03316.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

It has been suggested that contact allergy to hydrocortisone alcohol is a frequent phenomenon, A recent study showed that all patients with allergic patch reactions to tixocortol pivalate reacted to intradermal hydrocortisone sodium phosphate. We studied patients with positive patch test reactions to tixocortol pivalate but negative to hydrocortisone alcohol, with penetration enhancers in hydrocortisone alcohol patch tests and oral challenges with hydrocortisone alcohol. Additionally, prick and intradermal tests with hydrocortisone sodium succinate were used. Using penetration enhancers and oral challenges enabled detection of more contact allergies to hydrocortisone alcohol compared to conventional patch testing alone. 9/12 patients with allergic reactions to tixocortol pivalate reacted to intradermal hydrocortisone sodium succinate. No immediate reactions were seen in prick or intradermal tests, suggesting that hydrocortisone contact hypersensitivity is probably not associated with immediate allergy to hydrocortisone. The present study suggests that allergic patch test reactions to tixocortol pivalate are caused by hypersensitivity to hydrocortisone alcohol itself or to one of its metabolites in the skin.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03317.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

In spite of the improved awareness of the potential for nickel, cobalt and chromium to en use skin allergy, the incidence of serialization to them is generally on the increase, especially for nickel. We review data from the literature and industry on transition metal contamination of consumer products and assess the hazard to man. Consumer products are defined as personal care items and detergent/cleaning products used regularly in domestic York. The analytical data demonstrate that consumer products are a relatively minor source of contact with nickel, cobalt or chromium. The traces found in consumer products will not be the primary cause of sensitization to these metals: levels will be too low and exposure too brief. A person sensitized to these metals has many other more significant sources of daily contact such as earrings, jewellery and metal objects. It is therefore necessary to focus on decreasing the high exposure to these transition metals from other sources rather than on possible trace amounts found in consumer products. Current good manufacturing practice ensures that trace nickel, cobalt and chromium concentrations in consumer products are less than 5 ppm of each metal, it is recommended that this be accepted as a standard for maximum concentrations and that the target should be to achieve concentrations as low as 1 ppm.

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03318.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Occupational allergic contact dermatitis from metallic mercury is rare. Here we present the only 2 patients with relevant occupational mercury allergy detected at our clinic since 1974. The first patient was a dental nurse who became sensitized to metallic mercury from amalgam when handling uncured amalgam without protective gloves. The second patient had previously been sensitized to mercury from topical medicaments and developed work‐related dermatitis when a mercury thermometer was broken at her place of work. Both patients had a positive patch test reaction to metallic mercur

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03319.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

An analytical quantitative high‐pressure liquid chromatography (HPLC) method was developed for simultaneous determination of all mercaptobeazothiazole derivatives in the mercapto mix patch testing standard. The stability of the mercaptobenzothiazoles constituting the mercapto mix was studied both in petrolatum and in buffer solution at pH 6.5, with and without glutathione. In petrolatum vehicle, dibenzothiazyl disulfide was the dominant compound found in stored mercapto mix. In buffer solution at pH 6.5, 2‐mercaptobenzothiazole and the sulfenamide derivatives morpholinyl mercaptobenzothiazole and N‐cyclohexyl‐2‐benzothiazyl sulfenamide were converted into dibenzothiazyl disulfide. In the presence of glutathione, both the sulfenamide derivatives and the dibenzothiazyl disulfide were rapidly converted into 2‐mercaptobenzothiazole. The findings explain the “cross‐sensitivities” reported for the mercaptobenzothiazole group as a result of chemical reactions resulting in one main hapten. The use of a single substance for patch testing for mercaptobenzothiazole hypersensit

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03320.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

A patient presented with a 3‐month history of conjunctivitis and periocular eczema. He had a 3‐year history of glaucoma and was being treated with 3 different locally applied eyedrops (Timoptic (timolol maleate) ophthalmic solution 0.25%, Pilocar (pilocarpine) ophthalmic solution 1%. and Propine (dipivalyl epinephrine hydrochloride) ophthalmic solution 0.1%). Patch testing with all 3 undiluted eyedrop solutions revealed a reaction only to Propine eyedrops. Patch testing to the individual components of Propine eyedrops revealed an allergic reaction to 0.5%, dipivalyl epinephrine hydrochloride that was apparent on the 2nd patch test reading. After discontinuing the Propine eyedrops, the conjunctivitis as well as the periocular dermatitis resolved, proving that the positive patch tests were relevant to both. It was reported that re‐exposure to dipivalyl epinephrine hydrochloride by intra‐ocular challenge was necessary to diagnose this allergy. This is the first demonstration of dipivalyl epinephrine hydrochloride allergy by patch testing. Since the 1st patch test reading (2 days) was weak. 2nd patch test (4 days) readings may be important in diagnosing this allergy by patch

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03321.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03322.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1993.tb03324.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY