摘要:

In spite of not knowing the numbers of people exposed and obviously incomplete reporting, the known mechanisms of alcohol cutaneous intolerance and the literature classified according to mechanisms are listed. Testing techniques for delayed‐ and immediate‐types are propo

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00719.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

The case is reported of a young atopic woman with combined Type I and possible Type IV allergy to human seminal plasma, as well as Type‐I allergy to latex. Clinical symptoms were swelling and a burning sensation on the vulva and in the vulvovaginal area during or after coitus, followed by vesiculation, lichenification and the development of generalized eczema. Diagnosis was confirmed by investigation (RAST, prick testing, histology). Literature on the subject is reviewe

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00720.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

A 48‐year‐old female silk‐screen printer had worked in the manufacture of circuit boards for 12 years before she got the first symptoms of dermatitis on her wrists and lower arms. On the 1st patch test session, epoxy resin and the remainder of the standard series were negative, while a plastics and glues series gave an allergic reaction to 4,4′‐diaminodiphenylmethane (DDM). The 2nd test session revealed allergic reactions to several acrylics, several epoxy compounds and 3 ink components. According to the material safety data sheets, 1 ink hardener contained DDM, but the causative agent in 1 ink and 1 ink hardener remained uncertain. The manufacturers of the 2 inks kindly provided us with their components for further patch tests. 2 of these components gave allergic reactions: triglycidyl isocyanurate (TGIC) and 2‐hydroxyethyl methacrylate (2‐HEMA). Our case report shows that the manufacture of circuit boards involves exposure to highly sensitizing chemicals. DDM, TGIC and 2‐HEMA should be remembered as silk‐screen printers' potential contact sensitizers in the manufacture

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00721.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Diazolidinyl urea (DIAZ) is a formaldehyde‐releasing preservative used in cosmetics and personal‐care products, which has been identified as a sensitizing agent in contact dermatitis. To determine whether DIAZ sensitization is secondary to formaldehyde release or due to its own allergenic properties, we reviewed 708 consecutive patch tests of patients with various dermatologic complaints. Profiles of the 58 individuals (8%) with DIAZ sensitivity were analyzed with respect to sex, age, exposures, and chronicity of dermatitis. Significant coexistent biocide reactivity was demonstrated for DIAZ and formaldehyde (81%); 12% reacted to DIAZ alone. We conclude that the primary mode of sensitization of DIAZ is via formaldehyde release and that independent contact allergy is less frequ

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00722.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

3 cases of allergic contact dermatitis from industrial rubber products were investigated using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC), GC‐mass spectrometry (GC‐MS) and high‐performance liquid chromatography (HPLC). Our studies revealed N‐isopropyl‐N′‐phenyl‐p‐phenylenediamine (IPPD), a typical rubber allergen, as a causative chemical in a case from a brand of heavy‐duty rubber gloves and a case from a black rubber ring for car manufacture, and zinc ethylphenyldithiocarbamate (ZEPC), a dithiocarbamate (DTC)‐type accelerator, as a causative chemical in a case from a brand of rubber work gloves: both IPPD and ZEPC, which showed positive patch test reactions, were confirmed in the extracts of the causative rubber products by

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00723.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

5 cases of allergic contact dermatitis from rubber footwear were investigated by a combination of patch testing in patients and chemical analysis of causative rubber products. Our studies revealed 2‐mercaptobenzothiazole (MBT) and benzothiazyl disulfide (MBTS) (typical allergenic accelerators) as causative chemicals in 3 cases from children's rubber shoes, ladies' rubber boots and ladies' canvas shoes. These 3 patients reacted to mercaptobenzothiazole‐type accelerators including MBT and MBTS. MBT and MBTS were determined in each item of causative footwear by chemical analysis, including extraction by shaking with acetone‐chloroform (1:1) mixture at room temperature and determination using reversed‐phase high‐performance liquid chromatography (RP‐HPLC). Subsequently, we identified styrenated phenol (SP), a newly found allergenic antioxidant, as a causative chemical in a case from ladies' canvas shoes. The patient reacted to SP but not to MBT and MBTS, though SP, MBT and MBTS were determined in the causative shoes by gas chromatography (GC). GC‐mass spectrometry (GC‐MS) and HPLC. We also identifiedp‐tert‐butylphenol‐formaldehyde resin (PTBP‐F‐R), (a known allergenic adhesive ingredient) as a causative chemical in a case from ladies' sneakers. The patient reacted to PTBP‐F‐R but not top‐tert‐butylphenol (PTBP), MBT and MBTS. These 4 compounds were determined in the causative sneakers by GC, GC‐MS and HPLC. Thus, our studies revealed that not only known allergens, such as MBT, MBTS and PTBP‐F‐R, but also a newly found one, such as SP, were important causes of allergic

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00724.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Despite the frequency of irritant contact dermatitis, very little is known about the duration of barrier function impairment following cumulative irritant contact dermatitis. We studied post‐irritation irritant reactivity by assessing the response to SLS irritation in previously irritated sites. Cumulative irritant contact dermatitis was induced on the forearms of 15 volunteers aged 18 to 50 years by repeated occluded application of 0.5% SLS I h per day over 3 weeks. 3, 6 and 9 weeks later, previously irritated and unirritated control sites were challenged with 2% SLS under occlusion for 23 h. Irritation was assessed by visual scoring, transepidermal water loss (TEWL) as an indicator of epidermal barrier function, and capacitance as a parameter of epidermal water content. While no difference in irritant reactivity between pre‐irritated and unirritated sites was observed 3 weeks following irritant contact dermatitis, there was a significant hyporeactivity of previously irritated skin as expressed by clinical scores, TEWL and capacitance at 6 and 9 weeks. Our results indicate that epidermal barrier function remains altered even 9 weeks after cumulative irritant contact dermatitis. With regard to patch testing, post‐irritation hyporeactivity might be a cause of false‐negative tests on previously irritate

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00725.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00726.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00727.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0105-1873    

DOI:10.1111/j.1600-0536.1994.tb00728.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY