摘要:

AbstractObjective: The purpose of this study was to clarify the association of multiple genital human papillomavirus (HPV) types with vulvar neoplasias.Methods: We examined vulvar neoplasias by the polymerase chain reaction (PCR) method, which can detect almost all genital HPV types sensitively (L1‐PCR).Results: Eight HPV types (types 6, 11, 16, 18, 52, 53, 56, and 68) were detected in 52 of 53 (98.1%) vulvar condylomas; 2 HPV types (types 16 and 18) were detected in all 6 Grade‐3 vulvar intraepithelial neoplasias; and 5 HPV types (types 6, 16, 18, 51, and 56) were detected in 8 of 11 (72.7%) invasive vulvar carcinomas. Detection of HPV types 52, 53, 56, and 68 in vulvar condylomas and detection of HPV types 51 and 56 in vulvar carcinomas are the first examples ever reported.Conclusion: This study suggests that more HPV types are associated with the generation of vulvar neoplasias than was thought to be the case up to

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00927.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractObjective: To evaluate the role of plasminogen activators (tPA uPA) and inhibitor (PAI‐1) in the pathogenesis of preeclampsia.Study Design: tPA uPA and PAI‐1 antigens were measured in amniotic fluid, maternal plasma, and placental homogenates in normal pregnancy by ELISA method and compared with that of preeclampsia.Results: In normal pregnancy, tPA, uPA and PAI‐1 levels increase as the gestation advance, but the increment of PAI‐1 in amniotic fluid (28.3‐fold) is larger than that of tPA and uPA (1.8‐fold, 8.5‐fold) (p<0.001). Decidua homogenates contained larger amount of PAI‐1 than villi. Whereas, villi had higher levels of tPA uPA than decidua (p<0.01). In preeclampsia, the significantly higher levels of PAI‐1 were observed in AF and decidua tissue as compared to the normals (p<0.01), and the increment of PAI‐1 in preeclampsia is larger than that of tPA, uPA.Conclusions: The elevated PAI‐1 level is associated with the preeclampsia and the imbalance between the plasminogen activators (tPA, uPA) and the inhibitor (PAI‐1) might be involved in the patho

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00928.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractObjective: The aim of this study was to determine the incidence of HbS and β‐thalassemia in the Northern Jordan.Study Design: The investigation targeted 3 areas of Northern Jordan. Blood samples from 2,290 volunteers were evaluated to determine the prevalence of HbS and β‐thalassemia by preparing a hemolysate for cellulose acetate electrophoresis. An additional 568 newborn samples were collected from the umbilical and analyzed for the presence of HbS using electrophoresis.Results: The overall prevalence of HbS and β‐thalassemia was 4.45% and 5.93%, respectively. The incidence of sickle cell trait in the newborn sample was 3.17%. The prevalence of both HbS and β‐thalassemia was higher in the Al‐Gor area in comparison to Ajloun and Irbid.Conclusion: A better understanding of the demographics of these diseases has the potential to aid in the more efficient utilization of health care resources and improved planning and provision of health

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00929.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractObjectives: The purposes of this study were to compare the efficacy of sublingual nifedipine with intravenous hydrallazine in the control of acute hypertension of pregnancy and to make a preliminary assesment whether sublingual nifedipine could be recommended for use by midwives faced with severe hypertension in pregnancy in a rural setting.Methods: Subjects were 200 consecutive patients admitted to Kuala Terengganu General Hospital, Malaysia with severe hypertension in pregnancy between August 1989 and June 1990.Admission criteria were an ongoing viable pregnancy more than 28 weeks and diastolic blood pressure (DBP) more than 120 mmHg.The patients were randomly divided into 2 groups. In group I, sublingual nifedipine 5 mg was administered and repeated after 15 minutes if DBP>120 mmHg; and in group II hydrallazine 5 mg was intravenously injected and repeated after 15 minutes if DBP>120 mmHg. Both groups were put on hydrallazine infusion if DBP>120 mmHg after 30 minutes. The Chi‐square test was used for analysis with significance at p<0.05.Results: There was no statistical difference in the efficacy of therapy for decreasing blood pressure between the 2 groups. The groups were comparable by age, parity, gestational age at presentation, birth weight of infants, incidence of postpartum haemorrhage and fetal distress. Caesarian section rates were similar. In the observational studies on nurses administering the drugs, no significant difficulties were observed.Conclusion: Sublingual nifedipine was comparable to IV hydrallazine in the treatment of acute hypertension of pregnancy. Nurses were able to administer sublingual nifedipine without difficult

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00930.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractA young female with primary amenorrhea and male karyotype (46/XY) is reported. Physical examination and clinical investigation of the patient suggested mixed gonadal dysgenesis (MGD). After gonadectomy, a tumor was found on the left side and histologically diagnosed gonadoblastoma. Postoperative decreased level of testosterone and estradiol reflected the activities of the tumor.

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00931.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractSchwannoma is generally a solitary, nodular, benign tumor of a peripheral nerve sheath, and it rarely affects the external female genitalia. Its most‐common locations are the head, neck, upper and lower extremities, posterior mediastinum, and retroperitoneum. We treated a 29‐year‐old woman with a vulvar schwannoma. A tumor of 2.5 cm in diameter was resected for treatment and biopsy. It was a capsulate tumor with a smooth surface, and was elastic in consistency. A histological examination revealed a swirling pattern with some palisading of spindle‐shaped cells in H.E. stains. Immunohistochemical studies showed the tumor to be positive for S‐100 protein and negative for desmin. As a result, the mass proved to be schwannoma originating from

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00932.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractA 15‐year‐old phenotypic female referred for the investigation of primary ammenorrhea, was found to have a 45 XO karyotype and an ovarian cyst. She demonstrated some of the features of Turner's syndrome, as well as virilization. On laparotomy, she was found to have bilateral gonadoblastomas. She was treated with total abdominal hysterectomy and bilateral salpingo‐oophorectomy. Subsequently, repeated chromosomal analysis detected the presence of Y chromosomes, which was confirmed by the use of polymerase chain reaction (PCR). The difficulties encountered in searching for the Y chromosome in patients with gonadoblastoma are discussed. Prophylactic gonadectomy is suggested in those cases associated with atypical fea

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00933.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractA pregnancy with polyhydramnios and abnormal antepartum fetal heart rate pattern was found to have multiple placental haemangiomas. Multiple placental haemangiomas can give rise to fetal cardiac failure due to a hyperdynamic circulation or fetal anaemia either due to haemodilution or possibly destruction of blood cells in the chorioangioma. Whether fluid restriction with or without diuretics or blood transfusion is the correct form of treatment of neonatal cardiac failure in such a case is discussed.

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00934.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractWe report here a case of Landry‐Guillain‐Barre‐Strohl syndrome (LGBSs) in pregnancy. The patient had rubella viral infection, and the patient's inspiratory ability rapidly weakened. In the end, aggressive plasmapheresis prevented the need for respiratory support and the inherent risk it poses in terms of maternal morbidity and mort

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00935.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

AbstractWe present a rare case of a 31‐year‐old woman with a mucinous ovarian tumor with sarcoma‐like mural nodules. The epithelial elements consisted of a mixture of benign, borderline‐malignant, and mucinous adenocarcinoma; the sarcoma‐like mural nodules consisted of pleomorphic and epulis‐like cells. The lesion was resected for an ovarian tumor. In an immunohistochemical study, these cells stained for lysozyme and vimentin. The patient received 2 courses of cisplatin (100 mg/m2). There was no evidence of disease at a second‐look laparotomy after 1 year, and none upon examination 6 years after the initial operation. The mural nodules might be of non‐epithelial origin. The prognosis of patients with this rare lesion appears favorable, according to this and p

ISSN:1341-8076    

DOI:10.1111/j.1447-0756.1996.tb00936.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY