摘要:

Cycloheximide is an antimitotic and an inhibitor of the synthesis of both DNA and protein. Topical application in low concentrations (0.1 %– 0.2 %) resulted in definite involution of psoriatic plaques. Because of its potency this experimental drug – not yet available for clinical use – was employed on small areas only and with extreme caution. Results of a full evaluation for safety, currently in progress, are being awaited with int

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00840.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A 73‐year‐old woman from Guyana had nodular keloidal lesions on her face which had persisted for 56 years. A biopsy of the lesion revealed lobomycosis, a rare fungal infection. Microscopically, numerous fungi were seen in giant cells and macrophages. The macrophages had abundant pink reticulated cytoplasm. These macrophages in lobomycosis, considered by some in the past to be granular myoblastoma cells, were rich in glycoproteins and appeared to be “Gaucher‐like cells” in electromicrographs. Further, a transition of macrophages containing organisms to Gaucher‐like cells was noted. Antibodies to the fungus were demonstrated in the patient's serum by counter immunoelectrophoresis and indirect immunofluorescence studies. We postulate that the Gaucher‐like cells formed because of the inability of host macrophages to digest glycoproteins in the capsule of this u

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00841.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A 63‐year‐old white male presented with a nine‐month history of a nontender ulcerated lesion on his ear. Light microscopy demonstrated a moderately well circumscribed lesion in the dermis which abutted upon epidermis. There was no evidence of continuity between the tumor and overlying epithelium. The tumor was very cellular with an admixture of cells ‐ spindle, polyhedral and bizarre giant cells. Mitotic figures were abundant and frequently abnormal. We interpreted this lesion to have the clinical and pathologic features of an atypical fibroxanthoma (AFX). Ultrastructure, however, showed abundant tonofilaments and desmosomes indicative of an epithelial origin and therefore most consistent with a spindle cell squamous carcinoma (SCSC). It is urged that, when possible, electron microscopy be performed on problematic cases diagnosed either as an AFX or spindle cell squamous carcinoma since it is the most valid basis on which a correct diagnosis can

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00842.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Acid phosphatase activity has been studied in normal and X‐irradiated rat epidermis. A remarkable reaction increment was found in irradiated epithelium at the granular layer keeping the same pattern of distribution observed in the normal tissue. No reactive lysosomes or keratinosomes were observed in the cytochemical sections, while many keratinosomes but no lysosomes appeared in the electron microscopic preparations of irradiated animals. Irradiated epithelium is discussed as a suitable model to analyze the role of acid phosphatase in the keratinization mechanism

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00843.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Typical pustular lesions of impetigo herpetiformis were examined by electron microscopy. In the upper layers of the epidermis degenerated keratinocytes and neutrophils lay close together and amorphous substances were seen within and outside the keratinocytes. Neutrophiles were not observed within the keratinocytes. The spongiform pustules of Kogoj observed with light microscopy were made up of a large number of neutrophils in a network of degenerated and stretched‐out keratinocytes. Amorphous masses of high electron density which seemed to represent highly degenerated keratinocytes were observed among neutrophil

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00844.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A case of localized chronic pemphigoid with positive basement membrane zone immuno‐fluorescence is reported. The initial biopsy showed dermal papillary microabscesses resembling dermatitis herpetiformis although a subsequent biopsy revealed a subepidermal bull

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00845.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Four imidazole derivatives have now undergone extensive open and comparative trials as topical agents in dermatomycoses and vaginal candidosis. They are chlormidazole (Chemie Grünenthal), clotrimazole (Bayer), miconazole (Janssen) and econazole (Janssen, CilagChemie); all also have some antibacterial activity. Many other imidazoles have been marketed, usually as antiprotozoal or anthelminthic agents, and some of these have some anti‐mycotic activity as well as other miscellaneous therapeutic properties. The mode of action of imidazole antimycotic agents is discussed; after prolonged topical application to animals and human subjects, systemic absorption is negligible. All four agents which are available as cream, powder, lotion or vaginal tablets have many successful studies to their credit, often with clinical and mycological cure rates of over 80 % in a variety of dermatomycoses and in vaginal candidosis. The relative value of these topical agents is discussed, and it is suggested that in severe and extensive dermatomycoses consideration should be given to the systemic use of miconazole in support of topical thera

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00846.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00847.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1976.tb00848.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY