摘要:

We report the light and electron microscopic study of 7 examples of an unusual clear cell variant of basal cell epithelioma (BCE). The clear cells show cytoplasmic vacuoles that contain glycogen but do not stain with mucicarmine or fat stains. By electron microscopy the cytoplasmic vacuoles consist of empty spaces not surrounded by membranes. The clear cell pattern may occupy all or part of a given tumor. Typical nodular BCE was found in all 7 cases, but not in every section. Some nodules were composed of mixed solid and clear cell types. Differentiation of this uncommon variant from other clear cell tumors is important.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00507.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The staining patterns of normal sweat glands and sweat gland‐derived neoplasms using 2 monoclonal antibodies to keratins (Dako‐CKl, Cam 5.2) has been assessed. Based on findings in normal glands, the differentiation of these benign neoplasms is considered, with positive evidence for apocrine and eccrine differentiation, and in the latter, differentiation to ductal or secretory type epithelia. This easily applied technique (indirect immunoperoxidase) is suitable for use in routinely processed tissue and employs 2 commercially available monoclonal antibodies. The findings may be of assistance in general surgical reporting of problematic ca

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00508.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The histopathologic findings in 331 cases of necrobiosis lipoidica diabeticorum seen during a 50‐year period were reviewed. Three cases showing cholesterol cleft formation were found. All 3 cases were associated with severe diabetes mellitus. The differential diagnosis of importance is necrobiotic xanthogranuloma. Common features included extensive hyaline necrobiosis and foreign‐body giant cells. Atypical and Touton‐typc giant cells are more common in necrobiotic xanthogranuloma. Vascular changes in necrobiotic xanthogranuloma may include granulomatous involvement of muscular walls with thrombosis. Explanations for cholesterol cleft formation arc offered. When cholesterol clefts are seen in biopsy specimens of necrobiosis, necrobiotic xanthogranuloma must be ruled out. In addition, when found in necrobiosis lipoidica diabeticorum, these clefts may imply diabetes mellitus with complica

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00509.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Three patients arc reported, each with a reddish macule or plaque (7–10 mm) induced by trauma. The histology of these lesions showed hyperkeratosis, acanthosis and marked dilation of vessels in the papillary to deep dermis. The electron microscopic study revealed a layer of endothelial cells surrounding the dilated vessels, suggestive of telangiectasia. The relationship between this entity and solitary angiokcratoma is discusse

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00510.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Two cases of clear cell acanthoma are reported. The expression of carcinoembryonic antigen (CEA), involucrin and keratin proteins in the tumors was investigated immunohistochemically. In 1981, Penneys et al. reported that this tumor was not of sweat gland origin because of the absence of CEA. This study confirmed this, furthor, the pattern of positive reaction of involucrin also indicated that this tumor is not of swcat duct origin.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00511.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A 91‐year‐old patient with an extraskeletal osteosarcoma (characterized by atypical mesenchymal cells with ossification) of the forehead associated with a basal cell carcinoma is reported. Both osteoid and basal cell carcinoma nests were found embedded in a stroma containing markedly atypical cells. The 2 previously reported carcinosarcomas of the skin are revie

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00512.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Proliferation of sweat ducts has been described as a reactive process in a variety of benign and malignant neoplasms and inflammatory conditions in the skin, including scarring alopecia. However, to our knowledge this phenomenon has not been observed in non‐scarring alopecia. The following case documents such a proliferation arising in an alopecia consistent with alopecia areata. An 83‐year‐old female developed progressive, fairly well circumscribed patches of alopecia over a 2–3 year period. Unequivocal scarring was not present. Histopathological examination revealed non‐scarring alopecia with miniaturized and telogen follicles and a proliferation of eccrine ductal structures in the reticular dermis. These ductal structures varied in size and degree of cystic dilatation and resembled a primary eccrine neoplasm, such as syringoma. Only minimal focal fibrosis was observed in association with the eccrine proliferation. In summary, this case indicates that eccrine sweat duct proliferation may occur in non‐scarring alopecia and must be differentiated from a primary eccri

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00513.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Eruptive vellus hair cyst and steatocystoma multiplex are infrequent lesions. Although there are clinical similarities between both entities, histologic features are distinctive. Especially noteworthy is the presence of sebaceous glands within the cyst wall of steatocystoma. We describe herein a patient with a familial monomorphous papular eruption on the forehead, biopsies from which showed features of both eruptive vellus hair cyst and steatocystoma multiplex.

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00514.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

We report 2 cases of congenital porokeratotic eccrine nevus in a 5‐year‐old girl and a 7‐year‐old boy. The clinical manifestations were those of nevus comedonicus palmaris. The histologic picture consisted of comedo‐like dilatations and cornoid lamellae involving the eccrine ostia and ducts. One of the cases showed anomalies in the dermal eccrine ducts. We believe that these lesions are eccrine hamartomas unrelated to porokeratosis. We review similar cases from the literature and discuss the differential

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00515.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The homogeneous linear deposition of IgA along the basement membrane zone of uninvolved skin is a distinguishing feature of linear IgA dermatosis in adults and chronic bullous dermatosis of childhood. Although linear IgA deposition may be seen in other cutaneous diseases, to our knowledge, there are no previous reports of a direct association with cutaneous infection. We describe the finding of intense fluorescence, in a linear pattern, of IgA at the basement membrane zone in an elderly man with disseminated cutaneous varicella‐zoster infectio

ISSN:0303-6987    

DOI:10.1111/j.1600-0560.1988.tb00516.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY