ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02966.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A simple, cheap and reliable method of perfusion‐fixation of hearts is described using readily available domestic water fitments and a pump specifically designed for continuous pumping of corrosive fluids. Hearts fixed in this way readily lend themselves to dissection in echocardiographic planes so that strict correlation with clinical echocardiography may be made. Furthermore it is an excellent way to demonstrate functional valve pathology on post‐mortem mater

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02967.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Because so‐called ‘carcinoid’ tumour of the breast has proven to be a difficult entity to define, we studiedin‐situcarcinoma as there were reasons to believe that this might help clarify the complex problems involved. We studied a consecutive series of 30 cases of ductal carcinomain‐situ(DCIS) by light microscopy and silver impregnation methods and identified a relatively common endocrine variant of DCIS. This variant was studied by immunocytochemical and ultrastructural methods, using conventional DCIS as a control. Endocrine DCIS is identified by its organoid pattern, stromal ‘inclusions’, festooned structure and a distinctive type of polypoid invagination. It is argyrophilic and rich in neuron‐specific enolase. Ultrastructurally it contains abundant dense core granules which are impregnated selectively by Grimelius' method. This tumour type frequently contains peptide hormones of the ACTH family. Three of seven cases contained cells reactive for ACTH and corticotropin‐like intermediate lobe peptide CLIP or their precursor, proopiomelanocortin. A fourth tumour contained neurotensin, recently identified in a variety of endocrine tumours. Argyrophil invasive carcinomas are a much more heterogeneous group of tumours than argyrophil DCIS and only a minority have an endocrine structure comparable to th

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02968.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Recent papers have shown that malignant histiocytosis (MH) can be well controlled if the disease is diagnosed early and treated intensely. Previous reports proposed the usefulness of lymph nodes and liver biopsy or bone marrow aspiration in making a diagnosis of MH, but even when a combination of these three procedures was used, between 24 and 61% of patients with MH could not be correctly diagnosed. In the present study, clinical and autopsy findings in 25 patients with MH were reviewed to identify possible alternative diagnostic sites to lymph nodes, liver or bone marrow. Clinical symptoms were observed in the respiratory (40%) and gastro‐intestinal (48%) tracts. Proteinuria was also frequently identified (60%). Autopsy findings showed that involvement of lung, stomach and small intestine, and kidney by atypical histiocytes were present in 100% of patients with respiratory symptoms, 85% of those with abdominal symptoms and 80% of those with proteinuria, respectively. From the analysis of this pattern of histiocytic infiltration, lung, renal, gastric or jejunal biopsies are demonstrated as sites for the diagnosis of M

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02969.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Two cases of an unusual variant of the Stein‐Leventhal syndrome and ovary are described and two similar reported cases reviewed. Clinically three of the patients had a delayed menarche followed by irregular periods and one had irregular menorrhagia. Pathologically all four had large firm nodular ovaries of 6‐9 cm in diameter, showing a gross excess of stroma and distorted or fragmented atretic follicles with unusual granulosal cell persistence. Both grossly and microscopically, ovaries of this type are liable to be mistaken for tumours, but there is no good evidence that they are either neoplastic or pre‐neopl

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02970.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Two cases of papillary and cystic neoplasm of the pancreas (PCN) occurring in 17 and 21 year old women are reported with ultrastructural and immunohistochemical findings. A review of the English literature shows that although potentially malignant, PCN, which occurs mainly in young women, is amenable to surgical cure. The significance of large PAS positive and alpha‐1‐antitrypsin positive tumour granules; the lack of specificity of alpha‐1‐antitrypsin for pancreatic acinar cells; the possibility of acinar differentiation of PCN; and its separation from pancreaticoblastoma are di

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02971.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Seventy‐six cases of primary thyroid lymphoma have been reviewed employing the Kiel classification. These lymphomas are almost entirely of follicle centre cell origin, occur predominantly in elderly females, and are frequently associated with lymphocytic thyroiditis or Hashimoto's disease. The overall prognosis is variable, with long‐term survival in a substantial number of cases following thyroidectomy and radiotherapy. Results of histological examination including immunoperoxidase studies are described. It is proposed that thyroid lymphoma represents a neoplasm of mucosa‐associated lymphoid tissue (MALT), and the implications of this are disc

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02972.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Storage of alpha‐1‐antitrypsin (AAT) has been found in a small number of bile duct cells in liver tissue specimens from patients with Pi MZ, Pi SZ and Pi ZZ phenotypes. The storage appeared in the form of intracellular AAT immunoreactive inclusions. On EM investigation, AAT‐like material was detected within cisternae of the RER and SER. Such AAT inclusions were found in proliferating bile ductules in conditions such as cirrhosis, focal nodular hyperplasia and extrahepatic obstruction. They were also observed in normal biliary structures at the level of the canals of Hering, bile ductules and interlobular ducts in 13 out of 47 cases. These findings are interpreted as indicating that the intrahepatic bile duct cells are a further source of AAT, and that in case of defective export of AAT from the cell, as is the case for the Z protein, the protein accumulates not only in hepatocytes but in biliary cells as

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02973.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A case of Whipple's disease is described where the lymphatics in the regional lymph nodes appear to be obstructed by embolized macrophages, containing the characteristic PAS positive bacillary material. It is suggested that the regional lymphangectasia in Whipple's disease may in part result from such cellular embolism.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02974.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

A supraglottic laryngeal neuroendocrine tumour in a 71‐year‐old female is presented. In addition to the typical features of extra‐adrenal paragangliomas it showed unusual, numerous intracytoplasmic lumina and occasional true acini with accumulation of alcian blue and PAS positive secretory product in them which led originally to an erroneous diagnosis of metastatic adenocarcinoma. Ultrastructurally, the tumour was composed of light and dark chief cells containing varying numbers of dense‐core secretory granules. Intracytoplasmic lumina and true acini contained microvilli with glycocalyceal material and varying amounts of membranous and amorphous material, possibly secreted via small, smooth‐surfaced cytoplasmic vesicles but typical mucin granules were not seen. These features have not been previously described in laryngeal paragangliomas but are seen in endocrine tumours of other sites and have been used as an argument in favour of an endodermal rather than ectodermal origin for endocrine cells in those sites. Laryngeal paragangliomas are often malignant and the presence of spasmodic pain appears to be the most reliable indication of possible malignancy, histological criteria being as yet poorl

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1985.tb02975.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY