ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02892.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The histological features of prolymphocytic leukaemia are described in spleen, lymph nodes, liver and bone marrow from nine cases. Eight patients had B‐PLL one had T‐PLL. These features were compared with those of six cases of B chronic lymphocytic leukaemia (B‐CLL) with massive splenomegaly. Both PLL and B‐CLL showed enlargement of the white pulp with nodule formation and diffuse infiltration of the red pulp. In both PLL and CLL larger cells were found in the white pulp nodules often concentrated on the periphery producing a bizonal appearance. The extent of involvement of the white pulp was greater in PLL than in uncomplicated CLL. However, this was not so in two cases of B‐CLL in prolymphocytoid transformation in which the heavy replacement of the white pulp by large cells without a bizonal arrangement had effaced the red pulp. The cytological differences between PLL and CLL were best appreciated in splenic red pulp. The cells of CLL were small lymphocytes with clumped chromatin, those of PLL were larger with bigger nuclei, often indented in some cases, and distinct nucleoli. The pattern of infiltration in the bone marrow, liver and lymph nodes was similar in PLL and CLL. In conclusion, PLL can be distinguished from CLL by morphological and immunological features. The distinction is important clinically, because the survival of PLL is shorter than th

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02893.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

An unusual case is described of a West Indian man who presented with symptoms of an acute polyarthritis and who was found to have myelomatosis. At necropsy, generalized amyloidosis was found with particular involvement of synovial tissue. Myelomatosis presenting as an acute polyarthritis resembling rheumatoid arthritis is an uncommon, although well recognized entity, whereas an arthritic picture produced by amyloidosis is exceptional. The occurrence of joint pathology in myelomatosis and amyloidosis is discussed and the unique feature of intracytoplasmic amyloid deposition seen in this case is stressed.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02894.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Five benign histiocytomas of varying pattern and three malignant fibrous histiocytomas have been studied ultrastructurally. An essentially biphasic pattern of histiocytes and fibroblasts was present. In addition fibrohistiocytes, myofibroblasts and undifferentiated cells were present in some of the tumours. The histogenesis of this group of tumours is discussed. The value of electron microscopy in establishing the diagnosis in difficult cases is emphasized, but it is not considered useful in distinguishing benign from malignant cases.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02895.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The cytophotometric determination of the Feulgen‐DNA content of cell nuclei was performed on 72 fibrous histiocytomas. From the histograms, three variants of this neoplasm could be delineated and there was a fairly good correlation between the type of histogram and prognosis. With the exception of the benign dermal fibrous histiocytomas there was no correlation with the histological sub‐ty

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02896.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Retroperitoneal leiomyosarcoma arising in a spermatic blood vessel is described. In addition to typical leiomyosarcoma, areas of atypical histiocyte‐like cells and storiform pattern bearing a close resemblance to malignant fibrous histiocytoma, were seen. Ultrastructurally, cells with features of smooth muscle, partially differentiated cells with marginal densities and basal lamina and histiocyte‐like giant cells were present. Phagocytosis of inflammatory cells by tumour cells with marginal densities and an investment of basal lamina was observed. It is suggested that the precursor cell in this lesion was a primitive mesenchymal cell showing varying degrees of smooth muscle differentiation and giant cell format

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02897.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

To investigate the fine structural features of nuclei and cytoplasm in osteoclasts from patients with Paget's disease of bone, eight bone biopsies were examined. Unusual paracrystalline filamentous formations were found within the nuclei of both actively resorbing and degenerating osteoclasts. These formations were made up of parallel arranged filaments which, in most cases, clustered together regularly. The filaments were slightly argyrophilic and this helped to differentiate them from the surrounding nuclear matrix, even when they were not aggregated in clusters. Argyrophilic filaments were also found loosely aggregated inside the cytoplasm of osteoclasts. In three biopsies two additional and unusual cytoplasmic inclusions were found. The first consisted of irregularly branching, highly argyrophilic membranous strands which were located inside membrane‐bound vacuoles. The second consisted of spindle‐shaped structures enclosed by two membranes and containing three or more tubules. It is suggested that these results stand as further morphological evidence in favour of the view that a virus, possibly of the paramyxovirus class, has a pathogenetic role in Paget's disease of b

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02898.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A simple method for the recognition of hypercurvature of the seminiferous tubules in otherwise normal biopsies from infertile males consists of the recognition of characteristic ‘figure 8’ profiles of sectioned seminiferous tubules. Nineteen cases of morphometrically verified hypercurvature and 24 controls were tested in order to determine the validity of the method, which showed virtually no overlap in the two groups when at least four x 100 fields were assessed for ‘figure 8’ and grazing profiles. A recommended diagnostic approach, with cautions concerning pitfalls, is presented, and incidence, pathogenesis, and potential treatment are briefly di

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02899.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Repeated colonic and rectal biopsies from a 47‐year‐old woman with chronic watery diarrhoea showed an approximately 50 μ thick subepithelial band‐like collagenous deposit. The histopathological and clinical picture was consistent with the recently described condition of ‘collagenous

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02900.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The clinical, gross anatomical, light microscopic and ultrastructural features of two cases of adenocarcinoma of the pancreas of childhood are presented and compared with adult carcinoma of the pancreas. Both tumours showed acinar differentiation and zymogen granules were demonstrated by electron microscopy. A limited immunohistochemical study suggests that staining for α1‐antitrypsin may provide a marker for acinar differentiation. The histogenesis of this tumour is discussed in relation to the possible origins of islet cel

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1980.tb02901.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY