摘要:

The prognostic value of subjective histological and morphometric grading was studied in 75 primary ovarian carcinomas. Histological grading methods recommended by Czernobilsky and by Russell and the morphometric method of Baak and co‐workers were compared in a two‐observer system. The 5‐year survival could be correctly predicted in about two‐thirds of the patients with all three methods. When mitotic counting (volume corrected mitotic index, M/V‐index) was compared with the above grading methods by using a receiver operating characteristic curve) the M/V‐index was generally superior in its prognostic power regardless of the sensitivity/specificity level chosen. The morphometric grading method and the grading method based on the M/V index were also shown to be readily r

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01053.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A detailed histopathological study was made of the lungs of 36 cases of plexogenic pulmonary arteriopathy coming to combined heart‐lung transplantation. It revealed two dissimilar processes involved in the pathogenesis of this disease. One comprised histological appearances consistent with constriction of muscular pulmonary arteries, a condition that would be likely to be reversed by pulmanry vasodilators. The other was the proliferation of myofibroblasts in the intima and lumen of pulmonary arteries, a disorder of growth unlikely to be influenced by this type of therapy. In previous ultrastructural studies we have shown that the source of these cells of muscular pedigree is muscle cells from the inner half of the media which migrate into the intima through gaps in the inner elastic lamina. In the present study we found a similar proliferation of myofibroblasts in the intima, not only of pulmonary arteries, but also of pulmonary veins, in plexogenic pulmonary arteriopathy. Arterial thrombi found were considered to be a complication rather than a cause of plexogenic pulmonary arteriopathy. Siderophages, cholesterol granulomas and focal fibrosis in the lung were considered to be a consequence of intrapulmonary haemorrhage early in the course of the disease. It is concluded that, while plexogenic pulmonary arteriopathy has an important vasoconstrictive element, it is also based on a disorder of growth of cells of muscular pedigree. This view has clear implications for the therapy of primary plexogenic pulmonary arteriopath

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01054.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A study was made of the number of pulmonary endocrine cells, immunoreactive for gastrin‐releasing peptide (bombesin) or calcitonin, in the terminal bronchioles of 39 cases of pulmonary vascular disease. In 25 of these, the form of vascular disease was plexogenic pulmonary arteriopathy, primary in 12 and secondary in 13, while the remaining 14 subjects had a wide range of other varieties of hypertensive pulmonary vascular disease. We found that pulmonary endocrine cells, especially those containing bombesin, were increased in number in both the primary and secondary forms of plexogenic pulmonary arteriopathy but not in other varieties of pulmonary hypertension. The prominent bombesin‐containing cells were found in cases with cellular plexiform lesions but occurred even more prominently at an earlier stage when vascular smooth muscle cells were migrating from the inner media into the int

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01055.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The diagnosis of dysplastic naevus is in danger of falling into disuse in response to the continuing dispute as to its definition. This review tries to show that the lesion can be defined using histological and clinical criteria but that the individual features are not, by themselves, peculiar to dysplastic naevi. They are shared, in varying degrees, by other benign melanocytic naevi and by melanoma. The significance of these similarities is explained on the basis of the maturation of ordinary naevi and degrees of deviation from that common path. The recognition of severely aberrant differentiation in the form of classic dysplastic naevus is worthwhile, since in the appropriate clinical context and particularly in association with a family history of melanoma, it confers a very high risk of developing melanoma.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01056.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Elastosis, a previously unreported feature, was found to be common in granular cell tumours. Twenty‐four of 28 consecutive granular cell tumours were shown to display elastosis. The elastosis was found in three main sites: adventitial, interstitial and septal. Elastosis is statistically associated with the fibrosis present within this tumour. It appears that elastic fibres are synthesized by connective tissue cells, possibly induced by the tumour cell

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01057.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Mucin production by prostatic carcinomas is not unusual and the identification of acidic mucin with an appropriate stain may be a useful adjunct in routine diagnostic surgical pathology. In our series of 53 cases of prostatic carcinoma, 20 (38%) showed significant acidic mucin production. This may allow differentiation from benign, hyperplastic tissues which produce neutral mucins only. A case of colloid carcinoma of prostate is described which satisfies Elbadawi's criteria for this uncommon variant. Some suggestions are made which, if rigorously applied, will permit the recognition of genuine cases of colloid carcinoma and of the prognostic significance of mucin‐rich tumour

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01058.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The pattern of basement membrane deposition in the uterine ectocervix was assessed in benign, premalignant and malignant conditions, using an indirect immunoperoxidase technique to detect laminin, an intrinsic basement membrane component. A semi‐quantitative approach was used to assess the frequency of small break in the basement membrane. The cervical squamous epithelium in benign epithelial conditions has an almost completely continuous basement membrane, but the development of viral atypia or cervical intraepithelial neoplasia (CIN) is associated with the appearance of small basement membrane breaks. There is a correlation between increasingly severe CIN and increasing numbers of breaks, and there is a concurrent increase in the numbers of subepithelial inflammatory cells. The development of invasive neoplasm is associated with a sudden change to a fragmented pattern of basement membrane deposition, a finding which is of potential diagnostic us

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01059.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

We describe a technique for the localization of extracellular matrix proteins in wedge and needle biopsy specimens of human liver. Using ultra‐thin (50–70 nm) sections of puncture perfusion fixed tissue, extracellular matrix proteins were localized using a protein A‐gold labelling procedure. We obtained good preservation of ultrastructural detail and specific labelling for collagen types I, III and IV and fibronectin. The method represents a sensitive means of identifying the extracellular distribution and the cellular origin of these proteins in normal and diseased human

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01060.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

To further investigate the possible usefulness of antitransferrin receptor staining in the differential diagnosis between benign and malignant primary liver tumours, we examined the transferrin receptor expression in ten cases of focal nodular hyperplasia, six of nodular regenerative hyperplasia, two adenomas and six hepatoblastomas. In focal nodular hyperplasia, the ductular structures were always positive and the parenchymal cells displayed three staining patterns of moderate intensity. In nodular regenerative hyperplasia there was scattered, relatively weak transferrin receptor staining. The tumour cells in the adenomas were only weakly positive. Three hepatoblastomas showed an intense staining of tumour cells; one was weakly positive and two were negative. A high intensity of transferrin receptor staining, as previously described in hepatocellular carcinomas, was only observed in the hepatoblastomas. This gives further credence to the usefulness of strong transferrin receptor expression in evaluating the malignant nature of tumour foci in liver biopsies.

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01061.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Carcinosarcomas of the bladder are rare. We describe three such tumours, including an apparently unique case in which the components comprised liposarcoma and poorly‐differentiated transitional cell elements. A second example included chondrosarcomatous elements. These two tumours showed architectural and immunocytochemical features which suggested that they had originated as carcinomas but had subsequently differentiated along both epithelial and mesenchymal pathways. The third tumour contained both carcinoma and osteosarcoma and may represent a collision tumou

ISSN:0309-0167    

DOI:10.1111/j.1365-2559.1990.tb01062.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY